Biochemistry and Molecular Biophysics Graduate Group Faculty
Yeast genetics and biochemistry; research interest in mechanism and control of eukaryotic translation initiation.
Biochemistry of triacylglycerol biosynthesis; structure and function of membrane bound acyltransferases; genetically modifying the physical properties of seed oils for industrial and biofuel applications.
Yeast cytoskeleton, cell cycle regulation, cell signaling; Molecular and cell biology, genetics, and biochemistry; Evolution of biological complexity; CRISPR/Cas9-mediated gene editing technology.
Regulation of sodium and chloride transport by epithelial cells, with a focus on the functional interactions between the epithelial sodium channel (ENaC) and the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).
Evaluation of surface antigen genes of Ehrlichia chaffeensis and Ehrlichia canis and host immune response against the pathogens using experimental animal model systems.
Innate Immunity; Molecular Basis of Infectious Diseases and Host-Pathogen Interactions; Structural Biology and Molecular Recognition
Mechanisms that underly muscle structure and function.
Insect biochemistry, molecular biology and genetics; Mechanisms of iron metabolism in insects; Function of insect multicopper oxidases; Insect innate immunity
Pathogenic microbiology and bacterial genetics.
Understanding, treating, and preventing diarrheal disease caused by bacterial pathogens.
Insect biochemistry and molecular biology; structure and function of hemolymph serine proteinases, proteinase inhibitors, and antibacterial response proteins from insects; biochemistry of insect cuticle sclerotization.
Iron acquisition by active transport through the cell envelopes of bacteria; Immunological approaches to bacterial pathogenesis; Biophysical analyses of bacterial membrane transport in living cells.
Regulation of mosquito innate immunity; malaria parasite-mosquito interactions.
Structure based drug discovery for cancer and immunology; Computational structural biology and chemistry; Protein photonics for imaging
Specific isoforms of Protein Kinase C (PKC) that are regulated connexins during cancer formation.
Structural characterization and molecular recognition using Nuclear Magnetic Resonance (NMR) and Computer Aided Molecular Design (CAMD).
Synthetic organic chemistry, drug discovery, medicinal chemistry, chemical biology.
Theoretical Biological Physics; Protein phase behavior; Protein crystallization; Amyloid fibril formation; Drug formulations; Self-assembly.
Plant molecular biology, developmental biology, plant sterols, START domains, sterols and cellulose; broadly focusing on deciphering the molecular mechanisms underlying growth and development of flowering plants.
Understanding physiological regulation of epithelial ion transport.
Computer simulation of the structure and dynamics of peptides, proteins and nucleic acids; cosolvent effects on peptides and proteins; modeling of opioid peptides and their receptors.
Design and characterize atom of synthetic peptides for potential uses as drugs or renewable biomaterials. The lab employs a number of biologic, synthetic, analytic and physical methods to make these characterizations.
Human Papillomavirus; Viral Oncogenesis; DNA Damage Repair
Developing and implementing mass-spectrometry-based lipid profiling strategies to understand the roles of particular lipids, as well as genes and proteins involved in lipid metabolism and lipid signaling.
Molecular virology; Virus-host Interactions; Poxvirus replication; Gene expression; Transcriptomics; Genetic engineering; Virus and host innate immune-related genes.
Cell adhesion molecules and their role in cell growth and differentiation.
Protein structure and function, protein folding and aggregation, molecular chaperones and cellular stress.