Shijiao Huang, Ph.D.

Assistant Professor

Contact information

Office: Chalmers 62
Email: shijiaoh@ksu.edu
Lab website

Education

B.S. in Biology, 2005, Nanchang University, Jiangxi, China
Ph.D. in Cell Biology, 2012, Peking University, Beijing, China
Postdoc, 2017-2020, Dept. of Molecular & Integrative Physiology, University of Michigan - Ann Arbor
Postdoc, 2012-2017, Dept. of Molecular, Cellular and Developmental Biology, University of Michigan - Ann Arbor

Area of Specialty

My scientific goal is to understand the mechanisms of aging and to develop clinically relevant drugs to delay aging and enhance human health and longevity.

Environmental cues perceived by neurons and the responsive physiological changes are essential for human health. Our goal is to identify neural signaling in modulating aging and health, and at the same time advance the steps to develop the pharmacological interventions for aging and age-related diseases. We utilize approaches from molecular biology, genetics, neuroscience, and biochemistry in conjunction with multi-model systems (C. elegans and cell culture) to identify the neurons and signals underlying both aging and age-related diseases.

Honors and Awards

2025, K-INBRE Developmental Research Project Program (DRPP) Award
2025, The Cognitive and Neurobiological Approaches to Plasticity Center (CNAP) Pilot Project Award
2024, Johnson Cancer Research Center Expansion Award

Select Publications

Kitto ES*, Huang S*, Bhandari M, Tian C, Cox RL, Beydoun S, Wang E, Shave D, Miller HA, Easow SA, Henry E, Schaller ML, Leiser SF. The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit. eLife. 2025 Aug; 14:RP107651. *Equal contribution

Tuckowski AM, Huang S, Chambers K, Buscher B, Leiser SF. Deguelin promotes longevity and healthspan through C. elegans fmo-4. MicroPubl Biol. 2025;2025 PubMed Central PMCID: PMC11953735.

Huang S#, Cox RL, Tuckowski A, Beydoun S, Bhat A, Howington MB, Sarker M, Miller H, Ruwe E, Wang E, Li X, Gardea EA, DeNicola D, Peterson W, Carrier JM, Miller RA, Sutphin GL, and Leiser SF#. Fmo induction as a tool to screen for pro-longevity drugs. Geroscience. 2024 May 24. doi: 10.1007/s11357-024-01207-y. #Co-corresponding author

Kweon HK, Kong AT, Hersberger KE, Huang S, Nesvizhskii AI, Wang Y, Hakansson K, and Andrews PC. Sulfoproteomics Workflow with Precursor Ion Accurate Mass Shift Analysis Reveals Novel Tyrosine Sulfoproteins in the Golgi. J. Proteome Res. 2024 Jan 5;23(1):71-83. doi: 10.1021/acs.jproteome.3c00323.

Beydoun S, Kitto ES, Wang E, Huang S, and Leiser SF. Methodology to Metabolically Inactivate Bacteria for Caenorhabditis elegans Research. J Vis Exp. 2023 Jul 28;(197). doi: 10.3791/65775.

Choi HS, Bhat A, Howington MB, Schaller ML, Cox R, Huang S, Beydoun S, Miller HA, Tuckowski AM, Mecano J, Dean ES, Jensen L, Beard DA, Evans CR, Leiser SF. FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism. Nature Communications. 2023 Feb 2;14(1):562. doi: 10.1038/s41467-023-36181-0.

Huang S*, Haga Y*, Li J*, Zhang J*, Kweon HK, Seino J, Hirayama H, Fujita M, Moremen KW, Andrews P, Suzuki T, Wang Y. Mitotic phosphorylation inactivates the Golgi mannosidase MAN1A1. Cell Reports. 2022 Nov 22;41(8):111679. doi: 10.1016/j.celrep.2022.111679. *Equal contribution.

Miller HA*, Huang S*, Dean ES, Schaller ML, Tuckowski AM, Munneke AS, Beydoun S, Pletcher SD, and Leiser SF. Serotonin and dopamine modulate aging in response to food odor and availability. Nature Communications. 2022 Jun 7;13(1):3271. doi: 10.1038/s41467-022-30869-5. *Equal contribution

Beydoun S, Choi HS, Dela-Cruz G, Kruempel J, Huang S, Bazopoulou D, Miller HA, Schaller ML, Evans CR, Leiser SF. An alternative food source for metabolism and longevity studies in Caenorhabditis elegans. Communications Biology. 2021 Feb 26;4(1):258. doi: 10.1038/s42003-021-01764-4.

Huang S, Howington M, Dobry C, Evans CR, Leiser SF. Flavin-Containing Monooxygenases are conserved regulators of stress resistance and metabolism. Frontiers in Cell and Developmental Biology. 2021 Feb 12;9:630188. doi:10.3389/fcell.2021.630188..

Kruempel JCP, Miller HA, Schaller ML, Fretz A, Howington M, Sarker M, Huang S, Leiser SF. Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1-independent transcriptional response. Geroscience. 2020 Dec;42(6):1621-1633. PMID: 32399915; PMCID: PMC7732922.

Huang S, Wang Y. Golgi structure formation, function, and post-translational modifications in mammalian cells [version 1; peer review: 5 approved] F1000Research. 2017 Nov 27, 6(F1000 Faculty Rev):2050. PMID: 29225785; PMCID: PMC5710388.

Xu X*, Huang S*, Zhang B, Huang F, Chi W, Fu J, Wang G, Li S, Jiang Q, Zhang C. DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6. Nature Communications. 2017 Apr 27; 8:15164. PMID: 28447620; PMCID: PMC5414174. *Equal Contribution

Huang S, Tang D, Wang Y. Monoubiquitination of syntaxin 5 regulates Golgi membrane dynamics during the cell cycle. Developmental Cell. 2016 Jul 11;38(1):73-85. PMID: 27404360; PMCID: PMC4942811.

Huang S*, Xu X*, Wang G, Lu G, Xie W, Tao W, Zhang H, Jiang Q, Zhang C. DNA replication initiator Cdc6 also regulates ribosomal DNA transcription initiation. Journal of Cell Science. 2016 Apr 1;129(7):1429-40. PMID: 26872786. *Equal Contribution