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Department of Biochemistry and Molecular Biophysics

Biochemistry and Molecular BiophysicsBiochemistry and Molecular BiophysicsBiochemistry and Molecular BiophysicsBiochemistry and Molecular BiophysicsBiochemistry and Molecular BiophysicsBiochemistry and Molecular BiophysicsBiochemistry and Molecular BiophysicsBiochemistry and Molecular BiophysicsBiochemistry and Molecular BiophysicsBiochemistry and Molecular Biophysics

Department of Biochemistry & Molecular Biophysics
141 Chalmers Hall
1711 Claflin Rd.
Manhattan, KS 66506
785-532-6121
785-532-7278 fax
biochem@k-state.edu

Biotechnology Core Facility
206 Burt Hall
785-532-5956
785-532-6297 fax

Biomolecular NMR Facility
37 Chalmers Hall
785-532-2345

About BMB

Located in Chalmers and Burt Halls, the BMB Program offers B.A., B.S., M.S. and Ph.D. degrees. Departmental faculty have research programs supported by over $7 million in extramural support for studying various aspects of biochemistry in animals, plants, insects and microorganisms.

Browse this website to find information about our academics, faculty, seminars and more.

BMB students working at open house.
BMB represented well at K-State's Open House on April 9, 2022.
Select photo for a larger view.

PhD Defenses

Ye Zou successfully defended her doctoral dissertation entitled "The new insights into protein structures by computational methods" on April 26, 2022. Dr. Ho Leung Ng served as her faculty mentor. Congratulations Dr. Zou!

Yao Yan successfully defended her doctoral dissertation entitled "Development of CRISPR/Cas9-based gene drive biotechnology in S. cerevisiae on March 31, 2022. Her faculty advisor was Dr. Gregory Finningan. Congratulations Dr. Yan!

Mian Huang successfully defended her doctoral dissertation entitled "Structure-feature relationship of nuclear receptors and fluorescent proteins" on March 30, 2022. She was menotored by Dr. Ho Leung Ng. Congratulations Dr. Huang!

The Recent BMB Active Site News

Read the latest news in BMB. Fall 2020 Newsletter created by department faculty and staff. Adobe Acrobat Reader is required.

News Highlights

Brian Geisbrecht named Biochemistry & Molecular Biophysics' Newest University Distinguished Professor

Dr. Brian Geisbrecht, new University Distinguished Professor As one of the world's experts on the structure and biochemistry of proteins that function in the innate immune system, Dr. Brian Geisbrecht has received the lifetime honor of K-State's highest faculty title, university distinguished professor. He studies molecules produced by pathogenic bacteria that block activity of these innate immune components to understand their interactions and use that information as a basis for therapeutic discovery and development.

Since joining BMB in 2013, Geisbrecht has received NIH support of $5.8 million for his work. He has published numerous articles in prestigious journals including Journal of Immunology, Journal of Biological Chemistry and Proceedings of the National Academy of Sciences. Geisbrecht has served on national and international grant review panels and editorial boards of respected scientific journals. He has been invited to present at conferences and meetings across the U.S. and world. He has mentored four postdoctoral fellows, nine graduate students and 27 undergraduate researchers in his laboratory. Photo and story courtesy of K-State News.

BMB Undergrad Presents Research at the ASBMB Annual Meeting

Carson Gido presenting research posterCarson Gido, junior in biochemistry, was selected to present his research poster "Structural Basis for Nanomolar-Affinity Inhibition of Neutrophil Serine Protease Activity by the S. aureus EAP Domain Protein, Eap1" at the American Society for Biochemistry and Molecular Biology Annual Meeting April 2-5 in Philadelphia. Gido works with Brian Geisbrecht studying a white blood cell enzyme that, when over-activated, can cause lung cancer and other lung diseases. Gido's research experience and travel to the meeting were supported by the K-State Johnson Cancer Research Center through an Undergraduate Cancer Research Award. Photo and story courtesy of K-State News.

2020/2021 Biochemistry and Molecular Biophysics Charlie Hedgcoth, Jr. and Phillip Nordin Graduate Memorial Awards for Excellence

Jacob Weber (grad, Gorman), Xin Xu (grad, B. Geisbrecht) and Yao Yan (grad, Finnigan) were awarded for Excellence in Graduate Research.

 


Faculty Research Videos

Image of Dr. Michal Zolkiewski explaining research results to lab staffImage of Dr. Durrett helping a grad student with research and link to Dr. Durrett's Youtube research video
Dr. Michal Zolkiewski
Dr. Timothy Durrett
Image of Dr. Kanost discussing research poster with students.Image of Dr. Klebba's research meeting and link to Dr. Klebba's YouTube research video
Dr. Michael Kanost
Dr. Phillip E. Klebba
Image of Dr. Brian Geisbrecht overseeing research with lab staff and link to Dr. B. Geisbrecht's YouTube research videoImage of Dr. Erika Geisbrecht demonstrating research results and link to Dr. E. Gesbrecht's Youtube research video
Dr. Brian Geisbrecht
Dr. Erika Geisbrecht
Image of Dr. Tomich with student and link to Dr. Tomich's YouTube research video
Dr. John Tomich

Graduate Program

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Recent News

Mun, S., Noh, M. Y., Geisbrecht, E. R., Kramer, K. J., Muthukrishnan, S., Arakane, Y. 2022. Chitin deacetylases are necessary for insect femur muscle attachment and mobility. Proceedings of the National Academy of Sciences USA 119, e2120853119.

Anna Zolkiewska received an R21 grant from the National Institute of Allergy and Infectious Diseases entitled "Mechanistic links between mutations in the CLPB gene and congenital neutropenia".

Qu, M., Guo, X., Tian, S., Yang, Q., Kim, M., Mun, S., Noh, M. Y., Kramer, K. J., Muthukrishnan, S., Arakane, Y. 2022. AA15 lytic polysaccharide monooxygenase is required for efficient chitinous cuticle turnover during insect molting. Communications Biology 5, 518.

BMB undergrads Michael Bartkowski (Baral, biology) and Samira Laytimi (Schrick, biology) received Summer Undergraduate Research Awards from the College of Arts and Sciences.

Dreah Kuckelman (undergrad, biochemistry) was inducted into the Kansas State University chapter of Phi Beta Kappa, the nation's oldest and most prestigious academic honor society. K-State News

Ruth Mekuria (undergrad, biochemistry) was awarded the Above and Beyond Award from Developing Scholars. This award recognizes scholars who have done well in their research and beyond. K-State Today

BMB undergrad Samira Laytimi, (Schrick, biology) was awarded a Spring 2022 OURCI Research/ Creative Activity grant from the Office of Undergraduate Research and Creative Inquiry.

Two BMB student researchers presented in Kansas Undergraduate Research Days virtual event March 1-3, 2022. K-State News

  • Carson Gido (Brian Geisbrecht) - "Inhibition of Neutrophil Serine Proteases by Staphylococcus aureus Extracellular Adherence Protein Domains."
  • Dewey Leierer (Brenda Oppert, USDA) - "Shotgun Metagenomic Case Study of a Yellow Mealworm (Tenebrio Molitor) Colony Collapse"

Hannah Miller (undergrad, Prakash)Hannah Miller presented “NMR Structural and Dynamics Studies of an Insect Cytokine-like Stress Responsive Peptide” at the 20th Annual K-INBRE, January 13th-14th, 2022. Authors: Hannah Miller, Nitin Mishra, Haobo Jiang and Om Prakash.

BMB undergrad Cole Hayden (Welti, biology) received a Spring Undergraduate Research Award from the College of Arts and Sciences.

Fall 2021 K-State Johnson Cancer Research Center Undergraduate Awards K-state News

  • Kayden Creamer  – "Continued efforts of PhaC crystallization for cancer drug delivery using PHA"
  • Mikaela Garcia-Escamilla – "The role of tumor-suppressor gene Lhx6 during cellular migration of GABAergic interneurons in the zebrafish forebrain"
  • Carson Gido – "Inhibition of neutrophil serine proteases by EAP domain proteins"
  • Taryn Lubbers – "Peptide nanocarrier delivery of mRNA vaccines for treating melanomas"
  • Hannah Miller – "Understanding the molecular recognition basis of EGFR inhibitors for cancer treatment"
  • Abigail Parker – "Subcellular localization of putative transacylase"
  • Mia Thompson – "Macrophage Phenotypes in Mouse Melanoma"

Carson Gido, biochemistry undergrad, received the Kim Dierks Tutor of Distinction scholarship. Gido tutored students in biology, biochemistry and chemistry courses at the Academic Achievement Center. K-State Today

Xin Xu successfully defended her doctoral dissertation entitled “Structural and Functional Analysis of Complement Proteins” on November 19th, 2021, under the supervision of Dr. Brian Geisbrecht. Xin will be joining Bristol-Myers Squibb in Redwood City, CA as a staff scientist in January 2022. Congratulations Dr. Xu!

Jacob Weber successfully defended his doctoral dissertation entitled “Biochemical properties and physiological functions of extracellular iron-binding proteins” on August 27, 2021. Jacob was part of Dr. Maureen Gorman’s research team. His work greatly increased our knowledge of the structure and function of insect transferrin, and his findings will be the basis of future research to understand iron homeostasis in insects. Congratulations, Jacob!

Ashish Kumar successfully defended his doctoral disseration entitled “Fluorescence Measurement of Metal Uptake by Pathogenic Bacteria” on August 9, 2021. Ashish works in the lab of Dr. Phillip Klebba. Congratualations, Dr. Kumar!