Recent Department Achievements
Brian Geisbrecht named Biochemistry & Molecular Biophysics' Newest University Distinguished Professor
As one of the world's experts on the structure and biochemistry of proteins that function in the innate immune system, Dr. Brian Geisbrecht has received the lifetime honor of K-State's highest faculty title, university distinguished professor. He studies molecules produced by pathogenic bacteria that block activity of these innate immune components to understand their interactions and use that information as a basis for therapeutic discovery and development.
Since joining BMB in 2013, Geisbrecht has received NIH support of $5.8 million for his work. He has published numerous articles in prestigious journals including Journal of Immunology, Journal of Biological Chemistry and Proceedings of the National Academy of Sciences. Geisbrecht has served on national and international grant review panels and editorial boards of respected scientific journals. He has been invited to present at conferences and meetings across the U.S. and world. He has mentored four postdoctoral fellows, nine graduate students and 27 undergraduate researchers in his laboratory. Photo and story courtesy of K-State News.
- Erika Geisbreacht awarded National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Supplement to Advance Research (STAR) from projects to programs. She leads an NIAMS-supported research project using the Drosophila model to determine mechanisms that prevent protein aggregation, and ultimately cellular degeneration, in muscle.
- Anna Zolkiewska received an R21 grant from the National Institute of Allergy and Infectious Diseases entitled "Mechanistic links between mutations in the CLPB gene and congenital neutropenia".
- Phillip E. Klebba, Salete M. Newton, Brittany L. Nairn*, and Mathew Hansen* received a patent for "High-Throughput Fluorescent Screening Assay for Inhibitors of Gram-Negative Bacterial Iron Uptake"
* No longer at K-State.
- John M. Tomich, Gerald Reeck (deceased), Adriana Avila Flores* and Chandrasekar Raman* received a patent for "Nucleic Acid-Peptide Capsule Complexes." K-State Today
*No longer at K-State.
- Anna Zolkiewska was one of four featured investigators in "Angles of Attack" in the Spring 2022 edition of K-State's SEEK magazine.
- Erika Geisbrecht was featured in "Trimming Cancer: Biochemist discovers protein involved in normal and abnormal cell growth" in the 2022 edition of K-State Johnson Cancer Center's Conquest magazine.
- Mike Kanost received a National Institutes of Health, MIRA grant entiltled "Function of hemolymph plasma proteins in insect immune responses."
- Anna Zolkiewska received the Flossie West Breast Cancer Research Award from the K-State Johnson Cancer Research Center for "Imunotherapies for Breast Cancer"
Student Awards and Scholarships
2022 Biochemistry and Molecular Biophysics Charlie Hedgcoth, Jr. and Phillip Nordin Graduate Memorial Awards for Excellence
Hannah Miller (grad, Prakash) was awarded the 2022 Excellence in Graduate Research.
Shelby Innes (grad, Tomich) was awarded the 2021/2022 Excellence in Graduate Teaching.
Other Student Awards
- Three BMB majors were awarded Fall 2022 OURCI Research/ Creative Activity grants from the Offfice of Research and Creative Inquiry: Tyler Brown (Jeremy Schmit, Physics), Alexis Dawn Schlieper (Susan Brown, Biology and Will Tank) and Evie Flint (Mary Cain, Psychology). K-State Today
- BMB undergrads Michael Bartkowski (Baral, biology) and Samira Laytimi (Schrick, biology) received Summer Undergraduate Research Awards from the College of Arts and Sciences.
- Dreah Kuckelman (undergrad, biochemistry) was inducted into the Kansas State University chapter of Phi Beta Kappa, the nation's oldest and most prestigious academic honor society. K-State News
- Ruth Mekuria (undergrad, biochemistry) was awarded the Above and Beyond Award from Developing Scholars. This award recognizes scholars who have done well in their research and beyond. K-State Today
- BMB undergrad Samira Laytimi, (Schrick, biology) was awarded a Spring 2022 OURCI Research/Creative Activity grant from the Office of Undergraduate Research and Creative Inquiry.
- Carson Gido (undergrad, biochemistry) received the Kim Dierks Tutor of Distinction scholarship. Gido tutored students in biology, biochemistry and chemistry courses at the Academic Achievement Center. K-State Today
- Cole Hayden (Welti, biology) received a Spring Undergraduate Research Award from the College of Arts and Sciences.
BMB Undergrad Presents Research at the ASBMB Annual Meeting
Carson Gido, junior in biochemistry, was selected to present his research poster "Structural Basis for Nanomolar-Affinity Inhibition of Neutrophil Serine Protease Activity by the S. aureus EAP Domain Protein, Eap1" at the American Society for Biochemistry and Molecular Biology Annual Meeting April 2-5 in Philadelphia. Gido works with Brian Geisbrecht studying a white blood cell enzyme that, when over-activated, can cause lung cancer and other lung diseases. Gido's research experience and travel to the meeting were supported by the K-State Johnson Cancer Research Center through an Undergraduate Cancer Research Award. Photo and story courtesy of K-State News.
Fall 2021 K-State Johnson Cancer Research Center Undergraduate Awards
K-State News. BMB undergraduate and mentor unless otherwise noted.
- Kayden Creamer – Mentor: Ping Li (Chemistry) – "Continued efforts of PhaC crystallization for cancer drug delivery using PHA"
- Mikaela Garcia-Escamilla – Mentor:Thomas Mueller (Biology) – "The role of tumor-suppressor gene Lhx6 during cellular migration of GABAergic interneurons in the zebrafish forebrain"
- Carson Gido – Mentor: Brian Geisbrecht – "Inhibition of neutrophil serine proteases by EAP domain proteins"
- Taryn Lubbers (Life Sciences) – Mentor: John Tomich – "Peptide nanocarrier delivery of mRNA vaccines for treating melanomas"
- Hannah Miller – Mentor: Om Prakash – "Understanding the molecular recognition basis of EGFR inhibitors for cancer treatment"
- Abigail Parker – Mentor: Ruth Welti (Biology) – "Subcellular localization of putative transacylase"
- Mia Thompson – Mentor: Sherry Fleming (Biology) – "Macrophage Phenotypes in Mouse Melanoma"
- Wang G, Romero Y*, Thevarajan I*, and Zolkiewska A (2023) ADAM12 abrogation alters immune cell infiltration and improves response to checkpoint blockade therapy in the T11 murine model of triple-negative breast cancer. OncoImmunology, 12:1, 2158006, DOI: 10.1080/2162402X.2022.2158006.
*No longer at K-state
- Scarlet, J. M., Sprouse, P. A., Schroeder, J. D., Dittmer, N., Kramer, K. J., Kanost, M. R., Gehrke, S. H. 2022. Temporal changes in the physical and mechanical properties of beetle elytra during maturation. Acta Biomaterialia. 151, 457-467.
- Gorman, M.J. (2023) Iron homeostasis in insects. Annual Review of Entomology 68: 51-67. doi.org/10.1146/annurev-ento-040622-092836. Epub ahead of print.
- Weber, J.J., Brummett, L.M., Coca, M.E., Tabunoki, H., Kanost, M.R., Ragan, E.J., Park, Y., and Gorman, M.J. (2022) Phenotypic analyses, protein localization, and bacteriostatic activity of Drosophila melanogaster transferrin-1. Insect Biochemistry and Molecular Biology 147: 103811. doi: 10.1016/j.ibmb.2022.103811.
- Hannah J Lusk, Nicholas Neumann*, Madeline Colter, Mary R Roth, Pamela Tamura, Libin Yao, Sunitha Shiva, Jyoti Shah, Kathrin Schrick, Timothy P Durrett, Ruth Welti. Lipidomic Analysis of Arabidopsis T-DNA Insertion Lines Leads to Identification and Characterization of C-Terminal Alterations in FATTY ACID DESATURASE 6. Plant and Cell Physiology 2022 Jun 21;pcac088. doi: 10.1093/pcp/pcac088. Epub ahead of print. PMID: 35726963
*Nicholas Neumann (grad, Durrett)
- Geisbrecht BV, Lambris JD, Gros P. Complement component C3: A structural perspective and potential therapeutic implications. Semin Immunol. 2022 Jun 24:101627. doi: 10.1016/j.smim.2022.101627. Epub ahead of print. PMID: 35760703.
- Mun, S., Noh, M. Y., Geisbrecht, E. R., Kramer, K. J., Muthukrishnan, S., Arakane, Y. (2022) Chitin deacetylases are necessary for insect femur muscle attachment and mobility. Proceedings of the National Academy of Sciences USA 119, e2120853119.
- Qu, M., Guo, X., Tian, S., Yang, Q., Kim, M., Mun, S., Noh, M. Y., Kramer, K. J., Muthukrishnan, S., Arakane, Y. (2022) AA15 lytic polysaccharide monooxygenase is required for efficient chitinous cuticle turnover during insect molting. Communications Biology 5, 518.
- Xu X*, Lewis Marffy AL, Keightley A, McCarthy AJ, Geisbrecht BV. Group B Streptococcus Surface Protein β: Structural Characterization of a Complement Factor H-Binding Motif and Its Contribution to Immune Evasion. J Immunol. 2022 Mar 1;208(5):1232-1247. doi: 10.4049/jimmunol.2101078. Epub 2022 Feb 2. PMID: 35110419; PMCID: PMC8881398.
*Xin Xu (grad, BV Geisbrecht)
- Savitt AG, Manimala S, White T, Fandaros M, Yin W, Duan H*, Xu X*, Geisbrecht BV, Rubenstein DA, Kaplan AP, Peerschke EI, Ghebrehiwet B. SARS-CoV-2 Exacerbates COVID-19 Pathology Through Activation of the Complement and Kinin Systems. Front Immunol. 2021 Nov 5;12:767347. doi: 10.3389/fimmu.2021.767347. PMID: 34804054; PMCID: PMC8602850.
*Huiquan Duan and Xin Xu (grads, BV Geisbrecht)
- Souza SA*, Held A, Lu WJ, Drouhard B*, Avila B*, Leyva-Montes R*, Hu M, Miller III BR, Ng HL. (2021). Mechanisms of allosteric and mixed mode aromatase inhibitors. RSC Chem. Biol. Advance Article. 19 March 2021.
*Samson Souza (grad, Ng); *Brendan Drouhard, Bryant Avila, and Raul Leyva-Montes (undergrads, Ng)
- Xu X*, Zhang C, Denton DT, O'Connell D, Drolet DW, Geisbrecht BV. Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B. J Immunol. 2021 Feb 15;206(4):861-873. doi: 10.4049/jimmunol.2001260. Epub 2021 Jan 8. PMID: 33419768; PMCID: PMC7851746.
*Xin Xu (grad, BV Geisbrecht)
- Nicholas G. Neumann*, Tara J. Nazaremus, Jose A. Aznar-Moreno, Sergio A. Rodriguez-Aponte, Valerie A. Meijas Veintidos, Luca Comai, Timothy P. Durrett, Edgar B. Cahoon. (2021) Generation of camelina mid-oleic acid seed oil by identification and stacking of fatty acid biosynthetic mutants. Industrial Crops & Products 2021 January 159:113074. doi.org/
10.1016/j.indcrop.2020.113074. Epub 2020 Nov 18.
*Nicholas G. Neumann (grad, Durrett)
- Weber, J.J.*, Kashipathy, M.M., Battaile, K.P., Go, E., Desaire, H., Kanost, M.R., Lovell, S., and Gorman, M.J. (2020) Structural insight into the novel iron-coordination and domain interactions of transferrin-1 from a model insect, Manduca sexta. Protein Science, Nov 16. doi: 10.1002/pro.3999.
*Jacob J. Weber (grad, Gorman)
- Weber, J.J.*, Kanost M.R., and Gorman, M.J. (2020) Iron binding and release properties of transferrin-1 from Drosophila melanogaster and Manduca sexta: implications for insect iron homeostasis. Insect Biochemistry and Molecular Biology 125: 103438. doi: 10.1016/j.ibmb.2020.103438.
*Jacob J. Weber (grad, Gorman)
- Thevarajan, I., Zolkiewski, M., and Zolkiewska, A. (2020) Human CLPB forms ATP-dependent complexes in the mitochondrial intermembrane space. Int. J. Biochem. Cell Biol. 127, 105841
- Brooks D, Naeem F, Stetsiv M*, Goetting SC*, Bawa S, Green N, Clark C, Bashirullah A, Geisbrecht ER. Drosophila NUAK functions with Starvin/BAG3 in autophagic protein turnover. PLoS Genet. 2020 Apr 22;16(4):e1008700. doi: 10.1371/journal.pgen.1008700. PMID: 32320396
*Marta Stetsiv and Samantha Goetting (undergrads, E. Geisbrecht)
- Diana G. Najera*, Neal T. Dittmer, Jacob J. Weber, Michael R. Kanost, and Maureen J. Gorman. (2020) Phylogenetic and sequence analyses of insect transferrins suggest that only transferrin 1 has a role in iron homeostasis. Insect Science 31 March 2020. doi: 10.1111/1744-7917.12783.
*Diana Najera (undergrad, Gorman)
- Mi Young Noha, Sung Hyun Kimb, Maureen J. Gorman, Karl J. Kramer, Subbaratnam Muthukrishnan, Yasuyuki Arakane. Yellow-g and Yellow-g2 proteins are required for egg desiccation resistanceand temporal pigmentation in the Asian tiger mosquito, Aedes albopictus. Insect Biochemistry and Molecular Biology 122 (2020) 103386.
- Romero, Y., Wise, R., and Zolkiewska, A. (2020) Proteolytic processing of PD-L1 by ADAM proteases in breast cancer cells. Cancer Immunol. Immunother. 69:43-55
- Yu Song successfully defended his doctoral disseratation entitled "Genome-wide Association Study of Lipidomes of Arabidopsis thaliana Accessions Identifies Genes Affecting Lipid Metabolism under Unstressed and Stressed Conditions" on July 20, 2022. Song completed his degree under the mentorship of Dr. Ruth Welti in the Division of Biology. Congratulations, Dr. Song!
- Ye Zou successfully defended her doctoral dissertation entitled "The new insights into protein structures by computational methods" on April 26, 2022. Dr. Ho Leung Ng served as her faculty mentor. Congratulations Dr. Zou!
- Yao Yan successfully defended her doctoral dissertation entitled "Development of CRISPR/Cas9-based gene drive biotechnology in S. cerevisiae on March 31, 2022. Her faculty advisor was Dr. Gregory Finningan. Congratulations Dr. Yan!
- Mian Huang successfully defended her doctoral dissertation entitled "Structure-feature relationship of nuclear receptors and fluorescent proteins" on March 30, 2022. She was menotored by Dr. Ho Leung Ng. Congratulations Dr. Huang!
- Xin Xu successfully defended her doctoral dissertation entitled “Structural and Functional Analysis of Complement Proteins” on November 19th, 2021, under the supervision of Dr. Brian Geisbrecht. Xin will be joining Bristol-Myers Squibb in Redwood City, CA as a staff scientist in January 2022. Congratulations Dr. Xu!
- Jacob Weber successfully defended his doctoral dissertation entitled “Biochemical properties and physiological functions of extracellular iron-binding proteins” on August 27, 2021. Jacob was part of Dr. Maureen Gorman’s research team. His work greatly increased our knowledge of the structure and function of insect transferrin, and his findings will be the basis of future research to understand iron homeostasis in insects. Congratulations, Jacob!
- Ashish Kumar successfully defended his doctoral disseration entitled “Fluorescence Measurement of Metal Uptake by Pathogenic Bacteria” on August 9, 2021. Ashish worked in the lab of Dr. Phillip Klebba. Congratualations, Dr. Kumar!
Research and Exhibitions
- Carson Gido (undergrad, Brian Geisbrecht) presented a poster, “Structural Basis for Nanomolar-Affinity Inhibition of Neutrophil Serine Protease Activity by the Staphylococcus aureus EAP Domain Protein, Eap1” at the American Society for Biochemistry and Moleccular Biology annual meeting in Philadelphia, PA on April 2-5, 2022.
- Two BMB student researchers will present in Kansas Undergraduate Research Days virtual event March 1-3, 2022. K-State News
- Carson Gido (Brian Geisbrecht) - "Inhibition of Neutrophil Serine Proteases by Staphylococcus aureus Extracellular Adherence Protein Domains."
- Dewey Leierer (Brenda Oppert, USDA) - "Shotgun Metagenomic Case Study of a Yellow Mealworm (Tenebrio Molitor) Colony Collapse"
- Hannah Miller (undergraduate, Prakash) presented “NMR Structural and Dynamics Studies of an Insect Cytokine-like Stress Responsive Peptide” at the 20th Annual K-INBRE, January 13th-14th, 2022. Authors: Hannah Miller, Nitin Mishra, Haobo Jiang and Om Prakash.