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K-State Today

November 16, 2020

Michal Zolkiewski to present Anatomy and Physiology Seminar

Submitted by Gail Eyestone

Michal Zolkiewski, professor and department head of biochemistry and molecular biophysics, will present "Repurposing the Inhibitors of an Anti-Tumor Target in Search for Novel Antimicrobials" at the next Anatomy and Physiology Seminar at 4 p.m. Tuesday, Nov. 17, via Zoom, passcode A&P.

Zolkiewski's research areas of specialty include protein structure and function; protein folding, misfolding and aggregation; AAA+ ATPases in cellular physiology and pathogenesis; molecular chaperones and development of novel antimicrobials.

According to Zolkiewski, "Nearly every process in a living cell is carried out by protein complexes with highly organized structure and undergoing dynamic transformations. Our research is focused on the AAA+ superfamily of proteins. AAA stands for 'ATPases associated with a variety of cellular activities,' which implies that these proteins use energy from ATP and perform a variety of functions. Our laboratory performs basic research oriented toward understanding molecular mechanisms underlying the biological function of AAA+ proteins. We use a combination of biological, biochemical and biophysical experimental approaches to study interactions between proteins, protein localization inside living cells, and structural changes in proteins and protein complexes." 

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