November 9, 2017
Division of Biology presents Jonathan Wilson Yewdell
Jonathan Wilson Yewdell, National Institute of Allergy and Infectious Diseases, will present "The Case of the Missing Ribosomes and Other Tales of Protein Translation" as part of the Division of Biology Seminar Series at 4 p.m. Friday, Nov. 10, in 221 Ackert Hall.
Yewdell has made a number of fundamental contributions to understanding T cell immunosurveillance of viruses. These include proposing the DRiP hypothesis of class I peptide generation, that posits that defective translation products are a major source of viral MHC class I peptide ligands. This seminar will present the latest data from his lab on the contribution of DRiPs arising from nonstandard protein translation to peptide generation, including the first sightings of the previously mythical immunoribosome. The seminar also will describe experiments that examine the more general topic of protein translation in immune cell biology, and findings that pose a conundrum as to how CD8+ T cells replicate their proteome when dividing at maximal rates.
If you would like to visit with Yewdell, contact Pragyesh Dhungel at firstname.lastname@example.org