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College of Veterinary Medicine Core Facilities





Rhodes VL, Thomas MB, Michel K (2018) The interplay between dose and immune system activation determines fungal infection outcome in the African malaria mosquito, Anopheles gambiae. Dev Comp Immunol 85:125-133. PMID: 29649553 PMCID: PMC5935592 

Garcia M, Mamadova LK, Barton B, Bradford BJ (2018) Choline Regulates the Function of Bovine Immune Cells and Alters the mRNA Abundance of Enzymes and Receptors Involved in Its Metabolism in vitro. Front Immunol. 9: 2448. PMID: 30410489 PMCID: PMC6211314 

Montgomery SR, Mamedova LK, Zachut M, Kra G, Häussler S, Vaughn M, Gonzalez J, Bradford BJ (2018) Effects of sodium salicylate on glucose kinetics and insulin signaling in postpartum dairy cows. Journal of Dairy Science Available online 24 December 2018 In Press, Corrected Proof

Kondethimmanahalli C, Ganta R (2018) Impact of Three Different Mutations in Ehrlichia chaffeensis in Altering the Global Gene Expression Patterns. Sci Rep. 8: 6162. PMID: 29670161 PMCID: PMC5906474

Pierucci-Alves F, Midura-Kiela MT, Fleming SD, Schultz BD, Kiela PR (2018) Transforming Growth Factor Beta Signaling in Dendritic Cells Is Required for Immunotolerance to Sperm in the Epididymis. Front Immunol. 16;9:1882. PMID: 30166986 PMCID: PMC6105693

Packthongsuk K, Rathbun T, Troyer D, Davis D (2018) Porcine Wharton’s jelly cells distribute throughout the body after intraperitoneal injection. Stem Cell Research & Therapy 9:38. PMID: 29444715. PMCID: PMC5813394

Xiong Y, Neifert S, Karuppagounder SS, Liu Q, Stankowski JN, Lee BD, Ko HS, Lee YJ, Grima JC, Mao X, Jiang H, Kang SU, Swing D, Iacovitti L, Tessarollo L, Dawson TM, Dawson VL (2018). Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice. Proc Natl Acad Sci U S A 15:1635-1640. PMID: 29386392.  PMCID: PMC5816154.

Basel MT, Narayanan S, Ganta CK, Shreshta TB, Marquez A, Pyle M, Hill J, Bossmann SH, Troyer DL (2018) Developing a xenograft human tumor model in immunocompetent mice. Cancer Lett 412:256-263. PMID: 29054784.  PMCID:

Ishiguro S, Kawabata A, Zulbaran-Rojas A, Monson K, Uppalapati D, Ohta N, Inui M, Pappas CG, Tzakos AG, Tamura M (2018) Co-treatment with a C1B5 peptide of protein kinase Cγ and a low dose of gemcitabine strongly attenuated pancreatic cancer growth in mice through T cell activation. Biochem Biophys Res Commun 495(1):962-968. PMID: 29155177 PMCID: PMC5736436

Ward C, Rettig TA, Hlavacek S, Bye B, Pecaut MJ, Chapes SK (2018) Effects of spaceflight on the immunoglobulin repertoire of unimmunized C57BL/6 mice. Life Sciences in Space Research 16:63-75.

Rettig T, Ward C, Bye B, Pecaut MJ, Chapes SK (2018) Characterization of the naive murine antibody repertoire using unamplified high-throughput sequencing.  PLoS ONE 13: e0190982 PMID: 29320559.



Chandran P, Riviere JE, Monteiro-Riviere NA (2017) Surface chemistry of gold nanoparticles determines the biocorona composition impacting cellular uptake, toxicity and gene expression profiles in human endothelial cells. Nanotoxicology, 11:4, 507-519, PMID: 28420299

Honda K, Kim SH, Kelly MC, Burns JC, Constance L, Li X, Zhou F, Hoa M, Kelley MW, Wangemann P, Morell RJ, Griffith AJ (2017) Molecular architecture underlying fluid absorption by the developing inner ear.  eLife 6: e26851.  PMID: 28994389  PMCID: PMC5634787.

Wangemann P, Li X, Zhou F (2017) Gene expression in the embryonic endolymphatic sac of E13.5, E14.5, E16.5 and E17.5 Slc26a4Δ/+ and Slc26a4Δ/Δ mice.  NCBI GEO  GSE90092.

Rettig TA, Ward C, Pecaut MJ, Chapes SK (2017) Validation of methods to assess the immunoglobulin gene repertoire in tissues obtained from mice on the international space station. Gravit Space Res 5:2-23. PMID: 29270444 PMCID: PMC5736159.

Ishiguro S, Uppalapati D, Goldsmith Z, Robertson D, Hodge J, Holt H, Nakashima A, Turner K, Tamura M (2017) Exopolysaccharides extracted from Parachlorella kessleri inhibit colon carcinoma growth in mice via stimulation of host antitumor immune responses. PLoS One 12:e0175064 PMID: 28380056 PMCID: PMC5381895

Ortega MT, Riviere JE, Choi K, Monteiro-Riviere NA (2017) Biocorona formation on gold nanoparticles modulates human proximal tubule kidney cell uptake, cytotoxicity and gene expression. Toxicol In Vitro 42:150-160. PMID: 28433809

Rusk RA, Palmer MV, Waters WR, McGill JL (2017) Measuring bovine gamma delta T cell function at the site of Mycobacterium bovis infection.  Vet Immunol Immunopathol 193: 38-49. PMID: 29129226 PMCID: PMC5703227

Mills MK, Nayduch D, McVey DS, Michel K (2017) Functional validation of apoptosis genes IAP1 and DRONC in midgut tissue of the biting midge Culicoides sonorensis by RNAi. J Med Entomol 54:559-567 PMID: 28399198. PMCID: PMC5502902.

Choi K, Riviere JE, Monteiro-Riviere NA (2017). Protein corona modulation of hepatocyte uptake and molecular mechanisms of gold nanoparticle toxicity. Nanotoxicology 11(1):64-75 PMID:27885867

Silver K, Littlejohn A, Thomas L, Bawa B, Lillich JD (2017) Suppression of calpain expression by NSAIDs is associated with inhibition of cell migration in rat duodenum. Toxicology 383:1-12. PMID: 28342779 PMCID: PMC5519291.


Goering J, Pope MR, Fleming SD (2016) TLR2 Regulates Complement-Mediated Inflammation Induced by Blood Loss During Hemorrhage. Shock 45:33-9. PMID: 26679472. PMCID: PMC4685733.

Chapes SK, Ortega MT, Cheng C, Ganta RR (2016) Identification of T cell epitopes in the murine host response to Ehrlichia chaffeensis.  In: Rickettsiales Biology, Molecular Biology, Epidemiology, and Vaccine Development.  Ed: S Thomas.  Springer Int Publ.  Pp 197-214.  ISBN 978-3-319-46859-4.

Sang Y, Liu Q, Lee J, Ma W, McVey DS, Blecha F (2016) Expansion of amphibian intronless interferons revises the paradigm for interferon evolution and functional diversity.  Sci Rep: 6:29072.  PMID: 27356970. PMCID: 4928184.

Ishiguro S, Cai S, Uppalapati D, Turner K, Zhang T, Forrest CW, Forrest MF, Tamura T (2016). Intratracheal administration of hyaluronan-cisplatin conjugate nanoparticle significantly attenuates lung cancer growth in mice. Pharm Res 33:2517-29. PMID: 27335023. PMCID: PMC5007205.

Ishiguro S, Alhakamy NA, Uppalapati D, Delzeit J, Berkland C, Tamura M (2016). A combination delivery with an intravenous injection and an intratracheal aerosol spray of AT2R gene by modified TAT peptide nanoparticles attenuates human bronchioloalveolar carcinoma xenografts in immunodeficient mice. J Pharm Sci 106: 385-394.  PMID: 27769520. PMCID: PMC5161536.

Zhang X, An CJ, Sprigg KJ, and Michel K (2016). CLIPB8 is part of the prophenoloxidase activation system in Anopheles gambiae mosquitoes. Insect Biochem Mol Biol. 71: 106–115 PMID: 26926112 PMCID: PMC4828722

Madera R, Gong W, Wang L, Burakova Y, Lleellish K, Galliher-Beckley A, Nietfeld J, Henningson J, Jia K, Li P, Bai J, Schlup J, McVey S, Tu C, Shi J (2016) Pigs immunized with a novel E2 subunit vaccine are protected from subgenotype heterologous classical swine fever virus challenge. BMC Vet Res 12:197 PMID: 27612954. PMCID: PMC5016919


Silver K, Littlejohn A, Thomas L, Marsh E, Lillich JD (2015). Inhibition of Kv channel expression by NSAIDs depolarizes membrane potential and inhibits cell migration  by disrupting calpain signaling. Biochemical Pharmacology 98: 614-628. PMID: 26549367 PMCID: PMC4656099

Pierucci-Alves F, Akoyev V, Schultz BD (2015). Bicarbonate exchangers SLC26A3 and SLC26A6 are localized at the apical membrane of porcine vas deferens epithelium. Physiol Rep 3: e12380. PMID:25907791

Yuan K, Mendonça LGD, Hulbert LE, Mamedova LK, Muckey MB, Shen Y, Elrod CC, Bradford BJ (2015). Yeast product supplementation modulated humoral and mucosal immunity and uterine inflammatory signals in transition dairy cows. J Dairy Sci 98:3236-46. PMID: 25726103

Ishiguro S, Yoshimura K, Takao S, Kawabata A, Wall T, Tsunedomi T, Oka M, Inui M, Pappas C, Tzakos, AG, Tamura, M (2015). Involvement of an angiotensin II type 2 receptor (AT2R) signaling in human pancreatic ductal adenocarcinoma (PDAC): a novel AT2R agonist effectively attenuates growth of PDAC grafts in mice. Cancer Biol Ther 16:308-17. PMID: 25756513

Ohta N, Ishiguro S, Kawabata A, Uppalapati L, Ball J, Pyle M, Troyer D, De S, Zhang Y, Becker K,Tamura M (2015). Human umbilical cord matrix mesenchymal stem cells suppress the growth of breast cancer by expression of tumor suppressor genes. PLoS One 10: e0123756. PMID: 25942583

Alhakamy NA*, Ishiguro S*, Uppalapati D, Berkland CJ, Tamura M (2015). AT2R gene delivered by condensed polylysine complexes attenuates lewis lung carcinoma after intravenous injection or intratracheal spray. Mol Cancer Ther 15: 209-18.  PMID: 26637367.  *, Co-first authors.

Koči J, Jeffery B, Riviere JE, Monteiro-Riviere NA (2015). In vitro safety assessment of food ingredients in canine renal proximal tubule cells. Toxicol In Vitro 29:289-98. PMID: 25458622

Zhang LW, Koci J, Jeffery B, Riviere JE, Monteiro-Riviere NA (2015). Safety assessment of potential food ingredients in canine hepatocytes. Food Chem Toxicol 78:105-15. PMID: 25660481

Slone EA, Pope MR, Fleming SD (2015). Phospholipid scramblase 1 is required for β2-glycoprotein I binding in hypoxia and reoxygenation-induced endothelial inflammation. J Leukoc Biol 98: 791-804. PMID: 26216936

Pope MR, Fleming SD (2015). TLR2 modulates antibodies required for intestinal ischemia/reperfusion-induced damage and inflammation. J Immunol 194:1190-8. PMID: 25539820

Galliher-Beckley A1, Li X1, Bates JT1, Madera R1, Waters A1, Nietfeld J2, Henningson J2, He D3, Feng W4, Chen R3, Shi J5. (2015) Pigs immunized with Chinese highly pathogenic PRRS virus modified live vaccine are protected from challenge with North American PRRSV strain NADC-20. Vaccine 33:3518-25. PMID: 26049004


Wang Q, Schultz BD (2014). Cholera toxin enhances Na+ absorption across MCF10A human mammary epithelia. Am J Physiol Cell Physiol 306: C471–C484. PMID: 24371040 PMCID: PMC4042620

Sheng Yi, Fernando Pierucci-Alves, and Bruce D. Schultz (2013). Transforming growth factor-β1 impairs CFTR-mediated anion secretion across cultured porcine vas deferens epithelial monolayer via the p38 MAPK pathway. Am J Physiol Cell Physiol. 305(8): C867–C876. PMID: 23903699 PMCID: PMC3798679

Bryant WB, Michel K (2014). Blood feeding induces hemocyte proliferation and activation in the African malaria mosquito, Anopheles gambiae Giles. J Exp Biol 217:1238-45. PMID: 24363411 PMCID: PMC3990356

Dib LH, Ortega MT, Fleming SD, Chapes SK, Melgarejo T (2014) Bone marrow leptin signaling mediates obesity-associated adipose tissue inflammation in male mice. Endocrinology 155: 40-6. PMID: 24169547 PMCID: PMC3868799

Li S, Yuan K, Mamedova LK, Penner GB, Oba M, Beauchemin KA, and Bradford BJ (2014). High-grain diets suppress ruminal tissue abundance of angiopoietin-like protein 4 in cattle. J Anim Sci 92: 4077-85. PMID: 25085388

Li X, Galliher-Beckley AJ, Pappan L, Trible B, Kerrigan M, Beck A, Hesse R, Blecha F, Nietfeld JC, Rowland R, Shi J (2014).Comparison of Host Immune Responses to Homologous and Heterologous Type II Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Challenge in Vaccinated and Unvaccinated pigs. BioMed Res Int 2014: 416727. PMID: 24719862 PMCID: PMC3955659 

Magnani F, Pappas CG, Crook T, Magafa V, Cordopatis P, Ishiguro S, Ohta N, Selent J, Bosnyak S, Jones ES, Gerothanassis I P, Tamura M, Widdop  E, Tzakos AG (2014). Electronic Sculpting of Ligand-GPCR Subtype Selectivity: The Case of Angiotensin II. ACS Chem Biol 9: 1420-5. PMID: 24787922 PMCID: PMC4374176

Martel CA, Mamedova LK, Minton JE, Jones ML, Carroll JA, and Bradford BJ (2014). Continuous low-dose infusion of tumor necrosis factor alpha in adipose tissue elevates adipose tissue interleukin 10 abundance and fails to alter metabolism in lactating dairy cows. J Dairy Sci 97:4897–906. PMID: 24881787

Miller LC, Jiang Z, Sang Y, Harhay GP, Lager KM (2014) Evolutionary characterization of pig interferon-inducible transmembrane gene family and member expression dynamics in tracheobronchial lymph nodes of pigs infected with swine respiratory disease viruses. Vet Immunol Immunopathol 159:180-91. PMID: 24656980

Mills MK, Nayduch D, Michel K (2014). Inducing RNA interference in the arbovirus vector, Culicoides sonorensis. Insect Mol Biol 24: 105-14. PMID: 25293805. PMCID: PMC4286502

Sang Y, Bergkamp J, Blecha F (2014). Molecular Evolution of the Porcine Type I Interferon Family: Subtype-Specific Expression and Antiviral Activity. PloS One 9: e112378. PMID: 25372927 PMCID: PMC4221479

Sang Y, Blecha F (2014). Alternatives to antibiotics: an ecoimmunological view. Pathogens 4: 1-19. PMID: 25551290 PMCID: PMC4384068

Sang Y, Brichalli W, Rowland RRR, Blecha F (2014). Genome-wide analysis of antiviral signature genes in PRRSV-infected porcine macrophages at different activation statuses. PloS One. 9: e87613. PMID: 25056886 PMCID: PMC4178830

Sang Y, Rowland RRR, Blecha F (2014).  Antiviral regulation underlying the activation status of porcine monocytic innate immune cells. J Virol 88:11395-410. PMID: 25056886 PMCID: PMC4178830

Xie L, Fu Q, Ortega TM, Zhou L, Rasmussen D, O'Keefe J, Zhang KK, Chapes SK (2014) Overexpression of IL-10 in C2D macrophages promotes a macrophage phenotypic switch in adipose tissue environments. PLoS One 9: e86541. PMID: 24466141 PMCID: PMC3897709


Cheng C, Nair AD, Indukuri VV, Gong S, Felsheim RF, Jaworski D, Munderloh UG, Ganta RR (2013) Targeted and random mutagenesis of Ehrlichia chaffeensis for the identification of genes required for in vivo infection. PLoS Pathog. 9:e1003171. PMID:  23459099

Zhang T, Kedzierska-Mieszkowska S, Liu H, Cheng C, Ganta RR, Zolkiewski M (2013) Aggregate-reactivation activity of the molecular chaperone ClpB from Ehrlichia chaffeensis. PLoS One. 8:e62454. PMID: 23667479

Dawson HD, Loveland JE, Pascal G, Gilbert JG, Uenishi H, Mann KM, Sang Y, Zhang J, Carvalho-Silva D, Hunt T, Hardy M, Hu Z, Zhao SH, Anselmo A, Shinkai H, Chen C, Badaoui B, Berman D, Amid C, Kay M, Lloyd D, Snow C, Morozumi T, Cheng RP, Bystrom M, Kapetanovic R, Schwartz JC, Kataria R, Astley M, Fritz E, Steward C, Thomas M, Wilming L, Toki D, Archibald AL, Bed'Hom B, Beraldi D, Huang TH, Ait-Ali T, Blecha F, Botti S, Freeman TC, Giuffra E, Hume DA, Lunney JK, Murtaugh MP, Reecy JM, Harrow JL, Rogel-Gaillard C, Tuggle CK (2013) Structural and functional annotation of the porcine immunome.  BMC Genomics. 14:332. PMID: 23676093

Li X, Galliher-Beckley AJ, Huang H, Sun X, Shi J (2013) Peptide nanofiber hydrogel adjuvanted live virus vaccine enhances cross-protective immunity to porcine reproductive and respiratory syndrome virus. Vaccine. 31:4508-15.

Li X, Zhou F, Marcus DC, Wangemann P (2013) Endolymphatic Na+  and K+  concentrations during cochlear growth and enlargement in mice lacking Slc26a4/pendrin.  PLoS One 8: e65977. PMID: 23741519

Li X, Sanneman JD, Harbidge DG, Zhou F, Ito T, Nelson R, Picard N, Chambrey R, Eladari D, Miesner T, Griffith AJ, Marcus DC, Wangemann P. (2013) SLC26A4 targeted to the endolymphatic sac rescues hearing and balance in Slc26a4 mutant mice.  PLoS Genet 9: e1003641. PMID: 23874234

Drolia R, Von Ohlen T, Chapes SK (2013) Ehrlichia chaffeensis replication sites in adult Drosophila melanogaster. Int J Med Microbiol. 303:40-9. PMID: 23306065

Chitko-McKown CG, Chapes SK, Miller LC, Riggs PK, Ortega MT, Green BT, McKown RD (2013) Development and characterization of two porcine monocyte-derived macrophage cell lines. Results Immunol. 3:26-32. PMID: 23610747

Chapes SK, Ortega MT (2013) Understanding macrophage differentiation during space flight: The importance of ground-based experiments before space flight. Recent Patents Space Technol. 3:40-47. PMID: 24432200

Opoku-Acheampong AB, Unis D, Henningson JN, Beck AP, Lindshield BL (2013) Preventive and therapeutic efficacy of finasteride and dutasteride in TRAMP mice. PLoS One. 8:e77738. PMID: 24204943