September 16, 2021
Jeremy Wilusz to present Division of Biology Seminar
Jeremy Wilusz, associate professor of biochemistry and biophysics at the University of Pennsylvania Perelman School of Medicine, will present "Harnessing Endonucleases to Control Gene Outputs" as part of the Division of Biology Seminar Series at 3:30 p.m. Monday, Sept. 20, via Zoom.
For the information encoded in a eukaryotic protein-coding gene to be expressed, a functional RNA must first be generated. Such transcripts have been assumed to be linear, capped, spliced and polyadenylated. However, it is now clear that non-canonical RNA processing mechanisms can result in production of novel RNA classes, thereby altering a gene's output from what was expected. Our laboratory has long been interested in alternative processing pathways for nascent RNAs, and this talk will address our ongoing work on two novel mechanisms that are widely employed across eukaryotic genomes: (1) production of circular RNAs and (2) cleavage of nascent transcripts by the Integrator complex.
If you would like to visit with Wilusz, please contact Anna Zinovyeva at email@example.com.