A biosafety manual must be prepared when an activity involves infectious and/or recombinant DNA materials. This manual should be prepared to assist investigators, technicians, and collaborators in routine and/or emergency operation using rDNA or infectious materials. The manual should also be available to safety, and emergency response personnel in case of an incident, accident, or an emergency in a specific lab area. It should be a working document, reviewed periodically, updated as necessary, and readily accessible to all personnel working in a lab or area with infectious and/or recombinant agents. A training/familiarization sheet for all personnel working in a lab or area with infectious and/or recombinant agents should be part of the biosafety manual. A loose-leaf binder that can easily accommodate new materials is an effective option for maintaining a laboratory biosafety manual. View a sample Laboratory Biosafety Manual (DOC).