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Fleming Lab

Fleming Lab

Mailing Address
Kansas State University
Division of Biology
18 Ackert Hall

1717 Claflin Ave
Manhattan, KS 66506

office +1-785-532-6130
lab +1-785-532-6109





View a complete list of publications in NCBI

Selected Primary Publications 

* is graduate student, ** is undergraduate in Fleming lab

1. Regal JF, Strehlke ME, Peterson JM, Wing CR, Parker JE**, Nieto NF**, Bemis LT, Gilbert JS, Fleming SD. Role of IgM and angiotensin II Type I receptor autoantibodies in local complement activation in placental ischemia-induced hypertension in the rat. Mol Immunol. 2016 Oct;78:38-47. doi: 10.1016/j.molimm.2016.08.016. Epub 2016 Aug 30. PubMed PMID: 27588825; PubMed Central PMCID: PMC5056842.

2. Goering J**, Pope MR, Fleming SD. TLR2 Regulates Complement-Mediated Inflammation Induced by Blood Loss During Hemorrhage. Shock. 2016 Jan;45(1):33-9. doi: 10.1097/SHK.0000000000000477. PubMed PMID: 26679472; PubMed Central PMCID: PMC4685733.

3. Slone EA*, Pope MR, Fleming SD. Phospholipid scramblase 1 is required for B2-glycoprotein I binding in hypoxia and reoxygenation-induced endothelial inflammation. J Leukoc Biol. 2015 Nov;98(5):791-804. doi: 10.1189/jlb.3A1014-480R. Epub 2015 Jul 27. PubMed PMID: 26216936; PubMed Central PMCID: PMC4600063.

4. Pope MR, Fleming SD. TLR2 modulates antibodies required for intestinal ischemia/reperfusion-induced damage and inflammation. J Immunol. 2015 Feb 1;194(3):1190-8. doi: 10.4049/jimmunol.1303124. Epub 2014 Dec 24. PubMed PMID: 25539820; PubMed Central PMCID: PMC4297697.

5. Pope MR, Bukovnik U, Tomich JM, Fleming SD. Small B2-glycoprotein I peptides protect from intestinal ischemia reperfusion injury. J Immunol. 2012 Nov 15;189(10):5047-56. doi: 10.4049/jimmunol.1200290. Epub 2012 Oct 3. PubMed PMID: 23034168; PubMed Central PMCID: PMC3489961.

6. Tomasi M, Hiromasa Y, Pope MR, Gudlur S, Tomich JM, Fleming SD. Human B2-glycoprotein I attenuates mouse intestinal ischemia/reperfusion induced injury and inflammation. Mol Immunol. 2012 Oct;52(3-4):207-16. doi: 10.1016/j.molimm.2012.05.018. Epub 2012 Jun 27. PubMed PMID: 22750067; PubMed Central PMCID: PMC3565431.

7. Woods KM, Pope MR, Hoffman SM*, Fleming SD. CR2+ marginal zone B cell production of pathogenic natural antibodies is C3 independent. J Immunol. 2011 Feb 1;186(3):1755-62. doi: 10.4049/jimmunol.1002059. Epub 2010 Dec 27. PubMed PMID: 21187447; PubMed Central PMCID: PMC3024465.

8. Hoffman SM*, Wang H*, Pope MR, Fleming SD. Helicobacter infection alters MyD88 and Trif signalling in response to intestinal ischaemia-reperfusion. Exp Physiol. 2011 Feb;96(2):104-13. doi: 10.1113/expphysiol.2010.055426. Epub 2010 Nov 5. PubMed PMID: 21056969; PubMed Central PMCID: PMC3023829.

9. Hylton DJ**, Hoffman SM*, Van Rooijen N, Tomlinson S, Fleming SD. Macrophage-produced IL-12p70 mediates hemorrhage-induced damage in a complement-dependent manner. Shock. 2011 Feb;35(2):134-40. doi: 10.1097/SHK.0b013e3181ed8ec9. PubMed PMID: 20577145; PubMed Central PMCID: PMC3034979.

10. Hoffman SM*, Fleming SD. Natural Helicobacter infection modulates mouse intestinal muscularis macrophage responses. Cell Biochem Funct. 2010 Dec 2;28(8):686-94. doi: 10.1002/cbf.1709. PubMed PMID: 21104937; PubMed Central PMCID: PMC3021795.

11. Fleming SD, Pope MR, Hoffman SM*, Moses T, Bukovnik U, Tomich JM, Wagner LM, Woods KM. Domain V peptides inhibit beta2-glycoprotein I-mediated mesenteric ischemia/reperfusion-induced tissue damage and inflammation. J Immunol. 2010 Nov 15;185(10):6168-78. doi: 10.4049/jimmunol.1002520. Epub 2010 Oct 18. PubMed PMID: 20956350; PubMed Central PMCID: PMC3001127.

12. Hylton DJ**, Phillips LM**, Hoffman SM*, Fleming SD. Hemorrhage-induced intestinal damage is complement-independent in Helicobacter hepaticus-infected mice. Shock. 2010 Nov;34(5):467-74. doi: 10.1097/SHK.0b013e3181dc077e. PubMed PMID: 20220569; PubMed Central PMCID: PMC2998760.

13. Sparkes BL**, Slone EE*, Roth M, Welti R, Fleming SD. Intestinal lipid alterations occur prior to antibody-induced prostaglandin E2 production in a mouse model of ischemia/reperfusion. Biochim Biophys Acta. 2010 Apr;1801(4):517-25. doi: 10.1016/j.bbalip.2010.01.004. Epub 2010 Jan 18. PubMed PMID: 20083230; PubMed Central PMCID: PMC2826500.

Review Publications

1. Regal JF, Burwick RM, Fleming SD. The Complement System and Preeclampsia. Curr Hypertens Rep. 2017 Oct 18;19(11):87. doi: 10.1007/s11906-017-0784-4. Review. PubMed PMID: 29046976.

2. Regal JF, Dornfeld KJ, Fleming SD. Radiotherapy: killing with complement. Ann Transl Med. 2016 Mar;4(5):94. doi: 10.21037/atm.2015.12.46. PubMed PMID: 27047953; PubMed Central PMCID: PMC4791333.

3. Rettig TA, Harbin JN, Harrington A, Dohmen L, Fleming SD. Evasion and interactions of the humoral innate immune response in pathogen invasion, autoimmune disease, and cancer. Clin Immunol. 2015 Oct;160(2):244-54. doi: 10.1016/j.clim.2015.06.012. Epub 2015 Jul 2. Review. PubMed PMID: 26145788; PubMed Central PMCID: PMC4581967.

4. Slone EA, Fleming SD. Membrane lipid interactions in intestinal ischemia/reperfusion-induced Injury. Clin Immunol. 2014 Jul;153(1):228-40. doi: 10.1016/j.clim.2014.04.018. Epub 2014 May 9. Review. PubMed PMID: 24814240; PubMed Central PMCID: PMC4098654.

5. Fleming SD. Naturally occurring autoantibodies mediate ischemia/reperfusion-induced tissue injury. Adv Exp Med Biol. 2012;750:174-85. doi: 10.1007/978-1-4614-3461-0_13. PubMed PMID: 22903674.

6. Shishido SN, Varahan S, Yuan K, Li X, Fleming SD. Humoral innate immune response and disease. Clin Immunol. 2012 Aug;144(2):142-58. doi: 10.1016/j.clim.2012.06.002. Epub 2012 Jun 18. Review. PubMed PMID: 22771788; PubMed Central PMCID: PMC3576926