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Department Seminars Coffee and Cookies
Regulation of Fat Synthesis: Nutrigenomics and the Low-Fat Milk Syndrome
Dale E. Bauman Liberty Hide Bailey Professor
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Fat is the most variable component in milk and is markedly affected by diet. Known for over 150 years, the low-fat milk syndrome is a dramatic example that involves an interaction between rumen fermentation and mammary synthesis of milk fat. The presentation of this nutrigenomics example will provide historical context to developments in understanding nutritional affects on milk fat synthesis and highlight the biohydrogenation theory as a unifying concept that explains the basis for diet-induced milk fat depression. Emphasis will include recent developments in the application of genomic approaches to identify cellular signaling mechanisms that allow for the coordinated regulation of mammary lipogenic enzymes involved in milk fat synthesis. Broader implications of these nutrigenomic developments in the regulation of lipid synthesis will also be considered. |