Om
Prakash
Om
Prakash
Professor of Biochemistry
Structural Characterization and Molecular Recognition Using Nuclear Magnetic Resonance (NMR) and Computer Aided Molecular Design (CAMD).
B.S. 1970,
University of Meerut
B.S. 1970, University of Meerut
Ph.D. 1978, University of Meerut
Phone: 785-532-2345
Lab:
785-532-3108
Fax: 785-532-7278
Email: omp@ksu.edu
Office: 39 Chalmers
Our laboratory uses state-of-the-art
multidimensional NMR spectroscopy along with computer aided molecular modeling
to solve structural and dynamics problems in molecular pharmacology, rational
drug designing, protein folding and solution phase biostructure. We are
interested in utilizing structure of peptides, proteins, enzymes, receptors and
acceptors as templates in drug designing. We are also interested in developing
programs and routines for computer aided structure and conformation elucidation.
Once an accurate model is determined, we use it as a template for design of
appropriate constrained peptide ligands.
In summary, the integration of above mentioned knowledge such as
structure-function and molecular recognition may play a key role for the
successful design of pharmaceuticals in the future. Furthermore, these studies
can guide the design of future experiments, particularly that employing
recombinant DNA technology to create new protein structures useful in developing
resistance to insects and diseases in plants and animals.
Selected Publications
Huang, R., Zhiqiang, L., Dai, H., VanderValde, D., Prakash, O., and Jiang, H. (2007) The solution structure of clip domains from Manduca sexta prophenoloxidase activating proteinase-2. Biochemistry 46:11431-11439.
Lin, D., Shanks, D., Prakash, O.,Takemoto, D. J. (2007) Protein Kinase C Mutations in the C1B Domain Cause Caspase-3 apoptosis in Lens Epithelial Cells through Gap Junctions. Experimental Eye Research 85: 113-122.
Bommineni, Y., Dai, H., Gong, Y., Soulages, J. L.,.Frenando, S., DeSilva, U., Prakash, O., and Zhang, G. (2007) Fowlicidine-3 is an a-helical cationic host defense peptide with potent antibacterial and lipopolysccharide-neutralizing activities. FEBS Journal 274: 418-428
Sang, Y., Prakash, O., and Seib, P. (2007) Characterization of Phosphorylated Cross-Linked Resistant Starch by 31P Nuclear Magnetic Resonance Spectroscopy. Carbohydrate Polymers 67:201-212.
Y. Xiao;H. Dai;Y. Bommineni; J. Soulages; Y. Gong; O. Prakash; G.Zhang .(2006) Structure-Activity Relationships of Fowlicidin-1, a Cathelicidin Antimicrobial Peptide in Chicken. FEBS Journal 273: 2581-2593.
Xiao, Y., Cai, Y., Soulages, J. L., Prakash, O., Gilliland, S. E., and Zhang, G. (2006) Identification and functional characterization of three chicken cathelicidins with potent antimicrobial activity. J. Bio. Chem. 281: 2858-2867.
Cook, G. A., Pajewski, R., Aburi, M., Smith, P. E., Prakash, O., Tomich, J.M., and Gokel, G.W.(2006) NMR Structure and dynamic studies of an anion binding, channel-forming heptapeptide. J. Am. Chem. Soc. 128: 1633-1638.