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John Tomich B.A. 1974, University of Connecticut The Tomich laboratory designs and characterizes synthetic peptides for potential uses as drugs or renewable biomaterials. The lab employs a number of biologic, synthetic, analytic and physical methods to make these characterizations. |
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785-532-5956 |
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Selected Publications: Shank, L.P., Broughman, J.R., Brandt R.M., Robbins, A.S., Takeguchi, W., Cook, G.A., Hahn, L., Radke, G., Iwamoto, T., Schultz, B.D. and Tomich, J.M. (2006) Redesigning Channel-Forming Peptides: Amino Acid Substitutions in Channel-Forming Peptides that Enhance Rates of Supramolecular Assembly and Raise Ion Transport Activity. Biophys J. 90:2138-2150. Johnston, J.M., Cook, G.A., Tomich, J.M., Samson, M.S. (2006) Conformation And Environment Of Channel Forming Peptides: A Simulation Study. Biophys J. 90:1855-1864. Cook, G.A,, Pajewski. R,, Aburi, M., Smith, P.E., Prakash, O, Tomich JM, Gokel GW. (2006) NMR Structure and Dynamic Studies of an Anion Binding Channel-Forming Heptapeptide. J. Amer Chem Soc. 128:1633-1638. Xinchun Shen, Robyn Moore, Xiaoqun Mo, Shawnalea J. Frazier, Takeo Iwamoto, John M. Tomich, X Susan Sun (2006) Novel pH Dependent Adhesive Peptides. J. Nanosci. Nanotechnol. 6, 837-844. Xiaoqun Mo, Yasuaki Hiromasa, Ahlam Al-Rawi, Matt Warner, Takeo Iwamoto, Talat Rahman, Xiuzhi Sun and John M. Tomich. (2008) Design of 11-Residue Peptides with Unusual Biophysical Properties: Induced Secondary Structure in the Absence of Water. Biophysical J. 94:1807-1817. Suma Somasekharan, Robert Brandt, Takeo Iwamoto John M. Tomich, and Bruce D. Schultz (2008) Modulation of Epithelial Barrier Function by a Synthetic Peptide. J. Membr. Biol. 222: 17-30. Frederik W. van Ginkel, Takeo Iwamoto, Bruce D. Schultz and John M. Tomich (2008) Peptide-Specific Immunity to Self-derived, Anion Channel-Forming Peptides in the Respiratory Tract. Clinical and Vaccine Immunology. 15(2):260-266. |