April 7, 2022
Ulrich Tepass to present Division of Biology Seminar
Submitted by Division of Biology
Ulrich Tepass, professor of cell and systems biology at the University of Toronto, will present his research titled "The Rise and Fall of the Epithelial Phenotype: Mitotic Polarity Oscillation Drives Tumor Progression" as part of the Division of Biology Seminar Series at 3:30 p.m. Monday, April 11, via Zoom.
The majority of human cancers originate from epithelial cells including the lining of the gut, breasts and lungs. Using Drosophila as a model, Tepass investigates the machinery that controls the structural integrity of epithelia. Apical-basal cell polarity is a core architectural feature of epithelial cells that needs to be maintained to prevent tumor progression in most cancers. A second crucial aspect of tumor development is cell division which is accelerated in tumors and increases the number of cancer cells. Therefore, increased cell division and loss of cell polarity are two main drivers of epithelial cancer. How do cell division and epithelial polarity interact to promote tumor progression? Tepass amplifies the notion of a mitotic polarity oscillation, the transient loss of epithelial polarity during cell division, which severely challenges epithelial structure. Cell division similar to other morphogenetic processes exerts a stress on the epithelium that requires a more engaged polarity machinery to maintain tissue integrity. Tepass concludes the different levels of morphogenetic stress seen in different epithelia explain the large phenotypic variability resulting from the loss of individual polarity factors. And, cell division not only increases tumor size but also promotes tumor progression from hyperplastic, an adenoma-like, growth to neoplastic, or adenocarcinoma-like, growth.
If you would like to visit with Tepass, please contact Nirupama Kotian at email@example.com.