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Environmental Health and Safety

Environmental Health and Safety
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Kansas State University
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Appendix C: Peroxide Forming Chemicals Management

Class A - Severe Peroxide Hazard

Spontaneously decompose and become explosive with exposure to air without concentration. Test for peroxide formation before using or discard 3 months after opening or at the expiration date on the container if unopened. If a container of a Class A peroxide is past its expiration date, or if the presence of peroxides is suspected or proven, do not attempt to open the container.

Chemical NameCAS Number
Butadiene (liquid monomer)106-99-0
Isopropyl ether108-20-3
Sodium amide (sodamide)7782-92-5
Chloroprene (liquid monomer)126-99-8
Potassium amide17242-52-3
Tetrafluoroethylene (liquid monomer)116-14-3
Divinyl ether109-93-3
Potassium metal7440-09-7
Vinylidene chloride75-35-4

 

Class B - Concentration Hazard

Require external energy for spontaneous decomposition. Form explosive peroxides when distilled, evaporated or otherwise concentrated. Test these for peroxide formation before distillation or evaporation. Maintain a testing program/schedule to test for peroxide formation or discard 1 year after opening or at the expiration date on the container if unopened.

Chemical NameCAS Number
Acetal  105-57-7
Diethylene glycol dimethyl ether (diglyme)111-96-6
4-Methyl-2-pentanol108-11-2
Acetaldehyde75-07-0
Diethyl ether (ether)60-29-7
2-Pentanol6032-29-7
Benzyl alcohol100-51-6
Dioxanes 
4-Penten-1-ol821-09-0
2-Butanol78-92-2
Ethylene glycol ether acetates (glyme)110-71-4
1-Phenylethanol98-85-1
Cumene98-82-8
Furan100-00-9
2-Phenylethanol60-12-8
Cyclohexanol108-93-0
4-Heptanol589-55-9
Tetrahydrofuran (THF)109-99-9
Cyclohexene110-83-8
2-Hexanol626-93-7
Tetrahydronaphthalene (tetralin)119-64-2
2-Cyclohexen-1-ol822-67-3
Methylacetylene (gas)74-99-7
Vinyl ethers 
Decahydronaphthalene (decalin)91-17-8
3-Methyl-1-butanol123-51-3
Other secondary alcohols 
Diacetylene (butadine, gas)460-12-8
Methyl cyclopentane96-37-7
Dicyclopentadiene77-73-6
Methyl isobutyl ketone108-10-1

 

Class C - Shock and Heat Sensitive

Highly reactive and can auto-polymerize as a result of internal peroxide accumulation. The peroxides formed in these reactions are extremely shock- and heat-sensitive. Materials should be disposed of 1 year after opening or at the expiration date on the container if unopened.

Chemical NameCAS Number
Acrylic acid79-10-7
Chlorotrifluoroethylene (gas)79-38-9
Vinylacetylene (gas)689-97-4
Acrylonitrile107-13-1
Methyl methacrylate80-62-6
Vinyldiene chloride75-35-4
Butadiene (gas)               106-99-0
Styrene               100-42-5
Chlorobutadiene 
Tetrafluoroethylene (gas)116-14-3
Vinyl pyridine 
Chloroprene126-99-8
Vinyl acetate108-05-4
Vinyl chloride (gas)75-01-4

 

Class D

Materials that do not fit within Group A or B, but require special handling.

Chemical NameCAS Number
(2-Ethoxyethyl)-a-benzoyl benzoate604-63-7
1-(2-Chloroethoxy)-2-phenoxyethane2243-44-9
1-(2-Ethoxyethoxy)ethyl acetate 
1,1,2,3-Tetrachloro-1,3-butadiene 
1,1-Dimethoxyethane534-15-6
1,2-Bis(2-chloroethoxyl)ethane 
1,2-Dibenzyloxyethane622-22-0
1,2-Dichloroethyl ethyl ether623-46-1
1,2-Diethoxyethane629-14-1
1,2-Epoxy-3-isopropoxypropane4016-14-2
1,2-Epoxy-3-phenoxypropane122-60-1
1,3,3-Trimethoxypropene17576-35-1
1-Ethoxy-2-propyne 
1-Ethoxynaphthalene5328-01-8; 75440-80-1
1-Octene173994-67-7; 25377-83-7; 111-66-0
1-Pentene25377-72-4; 109-67-1
2,2-Diethoxypropane126-84-1
2,4-Dichlorophenetole5392-86-9
2,5-Hexadiyn-1-o 
2-Bromomethyl ethyl ether 
2-Chlorobutadiene 
2-Ethoxyethyl acetate 
2-Ethylacrylaldehyde oxime 
2-Ethylbutanol97-95-0
2-Ethylhexanal123-05-7
2-Methoxyethanol32718-54-0; 109-86-4
2-Methoxyethyl vinyl ether 
2-Methyltetrahydrofuran96-47-9
3-Bromopropyl phenyl ether 
3-Ethoxypropionitrile 
3-Methoxy-1-butyl acetate4435-53-4
3-Methoxyethyl acetate 
4,5-Hexadien-2-yn-1-ol 
4-Vinyl cyclohexene 
Acrolein 
Allyl ether 
Allyl ethyl ether 
Allyl phenyl ether 
a-Phenoxypropionyl chloride 
b,b-Oxydipropionitrile 
Benzyl ether 
Benzyl ethyl ether539-30-0
Benzyl methyl ether538-86-3
Benzyl n-butyl ether588-67-0; 3459-80-1
Benzyl-1-napthyl ether 
beta-Bromophenetole 
beta-Chlorophenetole 
Bis(2-(methoxyethoxy)ethyl) ether 
Bis(2-chloroethyl) ether 
Bis(2-ethoxyethyl) adipate 
Bis(2-ethoxyethyl)ether 
Bis(2-methoxyethyl) carbonate 
Bis(2-methoxyethyl) ether 
Bis(2-methoxyethyl) phthalate 
Bis(2-methoxymethyl) adipate 
Bis(2-n-butoxyethyl) phthalate 
Bis(2-phenoxyethyl) ether 
Bis(4-chlorobutyl) ether 
Bis(chloromethyl) ether 
b-Isopropoxypropionitrile 
b-Methoxypropionitrile 
Chloroacetaldehyde diethylacetal107-20-0; 107-30-2
Chloroethylene75-01-4
Chloromethyl methyl ether107-30-2
Cyclooctene931-88-4; 931-87-3
Cyclopropyl methyl etherN/A
Di(1-propynl) ether 
Di(2-propynl) ether 
Diallyl ether557-40-4
Diethoxybenzene (m-,o-,p-) 
Diethoxymethane462-95-3
Diethyl acetal 
Diethyl ethoxymethylenemalonate 
Diethyl fumarate 
Diethylketene 
Dimethoxymethane 
Di-n-propoxymethane 
Ethyl vinyl ether 
Ethyl-b-ethoxypropionate 
Ethylene glycol monomethyl ether 
Isoamyl benzyl ether 
Isoamyl ether 
Isobutyl vinyl ether 
Isophorone 
Isopropyl-2,4,5-trichlorophenoxy acetate 
Methoxy-1,3,5,7-cyclooctatetraene 
m-Nitrophenetole 
n-Amyl ether693-65-2
n-Butyl phenyl ether 
n-Butyl vinyl ether111-34-2
n-Hexyl ether112-58-3
n-Methylphenetole 
n-Propyl ether 
n-Propyl isopropyl ether 
o,p-Ethoxyphenyl isocyanate 
o.p-Iodophenetole 
o-Bromophenetole 
o-Chorophenol 
Oxybis(2-ethyl acetate) 
Oxybis(2-ethyl benzoate) 
p-(n-Amyloxy)benzoyl chloride 
p-Bromophenetole 
p-Chlorophenetole 
p-Dibenzyloxybenzene 
p-Di-n-butoxybenzene 
p-Ethoxyacetophenone 
Phenoxyacetyl chloride 
Phenyl-o-propyl ether 
p-Phenylphenetone 
Sodium 8-11-14-eicosatetraenoate 
Sodium ethoxyacetylide 
tert-Butyl methyl ether1634-04-4
Tetrahydropyran142-68-7
Triethylene glycol diacetate 
Triethylene glycol dipropionate 
Vinylene carbonate872-36-6

 

References:

  1. Clark D. E., “ Peroxides and Peroxide-Forming Compounds”, J. or Chem. Health and Safety, 2001 8(5), 12-18.
  2. Kelly, R. J., “ Review of Safety Guidelines for Peroxidizable Organic Chemicals”, Chem. Health & Safety, 1996, 3(5), 28–36.
  3. National Research Council, Prudent Practices in the Laboratory, National Academy Press: Washington, DC, 2011

Acknowledgement:

KSU Environmental Health and Safety acknowledges the assistance of the UC Santa Cruz Office of Environmental Health & Safety, whose webpage (https://ehs.ucsc.edu/lab-safety-manual/index.html) has served as useful resources.