John Tomich, Ph.D., Professor
Director of Biotechnology/Proteomics Core Facility
Undergraduate Advisor

Complete Publications List

1970s | 1980s | 1990s | 2000s | 2010s | 2020s | Book chapters | Patents issued


Tomich, JM., Mather, IH., and Keenan, TW. (1976) Proteins mask gangliosides in the milk fat globule and erythrocyte membranes. Biochim. Biophys. Acta 433, 357-364.

Chibber, BAK., Tomich, JM., Mertz, ET., and Viswanatha, T. (1977) Kinetic evidence for an intermediate in the deacetylation of monoacetyl-chymotrypsin. Proc. Natl. Acad. Sci. USA 74, 510-514.

Eigel, WN., Hofmann, JC., Chibber, BAK., Tomich, JM., Keenan, TW., and Mertz, ET. (1979) Plasmin-mediated proteolysis of casein in bovine milk. Proc. Natl. Acad. Sci. USA 76, 2244-2248.


Tomich, JM., Marti, C., and Colman, RF. (1981) Modification of two essential cysteines in rabbit muscle pyruvate kinase by the nucleotide analogue 5'-p-fluorosulfonyl-benzoyl guanosine. Biochemistry 20, 6711-6720.

Annamalai, AE., Tomich, JM., Mas, MT., and Colman, RF. (1982) Evidence for distinguishable sites of attack in the reactions of 5'-p-fluorosulfonyl-benzoyl adenosine and 5'-p-fluorosulfonyl-benzoyl guanosine with rabbit muscle pyruvate kinase. Arch. Biochem. Biophys. 219, 47-57.

Tomich, JM., and Colman, RF. (1985) Reaction of 5'-p-fluorosulfonyl-benzoyl-1,N6-ethenoadenosine with histidine and cysteine residues in the active site of rabbit muscle pyruvate kinase. Biochem. Biophys. Acta 827, 344-357.

Roise, D., Horvath, SJ., Richards, JH., Tomich, JM., and Schatz, G. (1986) A chemically synthesized mitochondrial signal peptide can form an amphiphilic helix and perturb natural and artificial phospholipid bilayers. EMBO J. 5, 1327-1334.

Roise, D., Theiler, F., Horvath, SJ., Tomich, JM., Richards, JH., Allison, DS., and Schatz, G. (1988) Amphiphilicity is essential for mitochondrial presequence function. EMBO J. 7, 649-653.

Tomich, JM., Carson, LW., Kanes, KJ., Vogelaar, NJ., Emerling, MR., and Richards, JH. (1988) Prevention of aggregation of synthetic membrane proteins by addition of detergent. Anal. Biochem. 174, 197-203.

Tamm, L., Tomich, JM., and Saier, M. (1989) Membrane incorporation and induction of secondary structure of synthetic peptides corresponding to the N-terminal signal sequences of the glucitol and mannitol permeases of E. coli. J. Biol. Chem. 264, 2587-2592.

Kersh, GJ., Tomich, JM., and Montal, M. (1989) The M2 transmembrane domain of the nicotinic cholinergic receptor forms ion channels in human erythrocyte membranes. Biochem. Biophys. Res. Comm. 162, 352-356.

Huang, S-H., Tomich, JM., Wu, H., Jong, A., and Holcenberg, J. (1989) Human deoxycytidine kinase. Sequence of cDNA clones and analysis of expression in cell lines with and without enzyme activity. J. Biol. Chem. 264, 14762-14768.

Barranger, JA., Ohashi, T., Hong, CM., Tomich, JM., Aerts, J.F.G.M., Tager, JM., Nolta, JA., Sender, LS., Weiler, S., and Kohn, DB. (1989) Molecular pathology and therapy of Gaucher disease. Japanese Journal of Inherited Metabolic Disease 51, 45-71.

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Morimoto, S., Kishimoto, Y., Tomich, M., Weiler, S., Ohashi, T., Barranger, JA., Kretz, KA., and O'Brien, JS. (1990) Interaction of saposins, acidic lipids and glucosylceramidase. J. Biol. Chem. 265, 1933-1937.

Gatanaga, T., Masunaka, I., Tomich, JM., Jeffes, E.W.B., Lentz, R., and Granger, GA. (1990) Identification of TNF-LT blocking factor(s) in the serum and ultrafiltrates of human cancer patients. Lymphokine Res. 9, 225-229.

Wu, LF., Tomich, JM., and Saier, MH. (1990) Structure and evolution of multidomain, multiphosphoryl transfer proteins: partial nucleotide sequence of the fructose (Fru) operon in Rhodobacter capsulatus and comparisons with homologous genes from other organisms. J. Mol. Biol. 213, 687-703.

Wu, HP., Holcenberg, JS., Tomich, JM., Chen,.J., Jones, PA., Huang, S-H., and Calame, KL. (1990) Inhibition of in vitro transcription by specific double-stranded oligodeoxynucleotides. Gene 89, 203-209.

Montal, M., Montal, MS. and Tomich, JM. (1990) Synporins: A novel class of synthetic proteins that emulate the pore structure of biological ion channels. Proc. Natl. Acad. Sci. USA 87, 6929-6933.

Shigematsu, H., Morimoto, S., Kishimoto, Y., Weiler, S., Tomich, J., Barranger, J., Shinohara, M., Yeager, AM., and O'Brien, JS. (1990) Saposins (Sphingolipid Activator Proteins) in the Twitcher Mutant mouse. J. Neurochem. 55, 1659-1662.

Gatanaga, T., Hwang, C., Korr, W., Cappuccini, F., Lucci III, JA., Jeffes, E.W.B., Lentz, R., Tomich, JM., Yamamoto, RS., and Granger, GA. (1990) Purification and characterization of an inhibitor (soluble TNF receptor) for TNF and LT obtained from the serum ultrafiltrates of human cancer patients. Proc. Natl. Acad. Sci. USA 87, 8781-8784.

Jiang, W., Wu, LF., Tomich, JM., Saier, MH., and Niehaus, WG. (1990) Corrected sequence of the mannitol (Mtl) operon in Escherichia coli. Mol. Microbiol. 4, 2003-2006.

Li, Z., Nicoll, DA., Hilgemann, DW., Penniston, JT., Weiss, JN., Tomich, JM., and Philipson, KD. (1991) Identification of a peptide inhibitor of the cardiac sarcolemmal Na+-Ca2+. J. Biol. Chem. 266, 1014-1020.

Smith, ET., Feinberg, BA., Richards, JH., and Tomich, JM. (1991) Physical characterization of a totally synthetic 2[4Fe-4S] Clostridial ferredoxin. J. Amer. Chem. Soc. 113, 688-689.

Ohashi, T., Hong, CM., Weiler, S., Tomich, JM. and Barranger, JA. (1991) Characterization of human glucocerebrosidase from different mutant alleles. J. Biol. Chem. 266, 3661-3667.

Kaartinen, V., Williams, JC., Tomich, JM., Yates, J., Hood, LE., and Mononen, I. (1991) Leukocyte glycoasparaginase: Inactivation and covalent modification with diazo-oxonorvaline. J. Biol. Chem. 266, 5860-5869.

Wu, LF., Reizer, A., Reizer, J., Cai, B., Tomich, JM., and Saier, MH. (1991) Nucleotide sequence of the Rhodobacter capsulatus fruK gene, which encodes fructose-1-phosphate kinase—evidence for a kinase superfamily including both phosphofructokinases of Escherichia coli . J. Bacteriol. 173, 3117-3127.

Hekman, C., Tomich, JM., and Hatefi, Y. (1991) Mitochondrial ATP synthase complex: Membrane topography and stoichiometry of the F0 subunits. J. Biol. Chem. 266, 13564-13571.

Jeffes, E., Schmitz, K., Yamamoto, R., Tomich, JM., Beckman, M., Nep, R., and Kanaver, M. (1991) A simple nonisotropic in vitro bioassay for LT and TNF employing NaF treated L-929 target cells that detects picogram quantities of LT and TNF and is as sensitive as TNF assays done with ELISA methodology. Lymphokine Res. 10, 147-151.

Grove, A., Tomich, JM., and Montal, M. A molecular blueprint for the pore-forming structure of voltage gated calcium channels. (1991) Proc. Natl. Acad. Sci. USA.88, 6418-6422.

Bechinger, B., Kim, Y., Chirlian, LE., Gesell, J., Neumann, JM., Montal, M., Tomich, J., Zasloff, M., and Opella, S. (1991) Orientation of amphipathic helical peptides in membrane bilayers by solid-state NMR spectroscopy. J. Biomolec. NMR 1, 167-173.

Yamada, Y., Chang, Y-Y., Daniels, GA., Wu, L-F., Tomich, JM., Yamada, M., and Saier, MH. (1991) Insertion of the mannitol permease into the membrane of Escherichia coli: Possible involvement of an N-terminal amphiphilic sequence. J. Biol. Chem 266, 17863-17871.

Smith, E., Tomich, JM., Iwamoto, T., Richards, JH., and Feinberg, B. (1991) A totally synthetic histidine-2 ferredoxin: Thermal stability and redox properties. Biochemistry 30, 11669-11676.

Vartak, NB., Reizer, J., Reizer, A., Gripp, JT., Groisman, EA., Wu, L-F., Tomich, JM., and Saier, MH. Jr. (1991) Sequence and evolution of the FruR protein of Salmonella typhimurium: a pleiotropic transcriptional regulatory protein possessing both activator and repressor functions which is homologous to periplasmic sugar binding proteins. Res. Microbiol. 142, 951-963.

Wu, LF., Reizer, A., Reizer, J., Cai, B., Tomich, JM., and Saier, MH. (1991) Nucleotide sequence of the Rhodobacter capsulatus fruK gene, which encodes fructose-1-phosphate kinase: evidence for a kinase superfamily including both phosphofructokinases of Escherichia coli. J. Bacteriol. 173, 3117-3127.

Portlock, SH., Lee, Y., Tomich, JM., and Tamm, LK. (1992) Insertion and folding of the N-terminal amphiphilic signal sequences of the mannitol and glucitol permeases of Escherichia coli. J. Biol. Chem. 267, 11017-11022.

Montal, MS., Blewitt, R., Tomich, JM., and Montal, M. (1992) Identification of an ion channel-forming motif in the primary structure of tetanus and botulinum neurotoxins. FEBS Lett. 313 (1), 12-18.

Montal, MS., Iwamoto, T., Tomich, JM.. and Montal, M. (1993) Design, synthesis and functional characterization of a pentameric channel protein that mimics the presumed pore structure of the nicotinic cholinergic receptor. FEBS Lett. 320, 261-266.

DeClerck, YA., Yean, T., Lee, Y., Tomich, JM., and Langley, KE. (1993) Characterization of the functional domain of tissue inhibitor of metalloproteinases-2 (TIMP-2). Biochem J 289, 65-69.

Grove, A., Tomich, JM., Iwamoto, T. and Montal, M. (1993) Design of a functional calcium channel protein: Inferences about an ion channel-forming motif derived from the primary structure of voltage-gated calcium channels. Protein Science 2, 1918-1930.

Montal, MS., Bühler, L., Iwamoto, T., Tomich, JM., and Montal, M. (1993) Synthetic peptides and four-helix bundle proteins as model systems for the pore-forming structure of channel proteins. II. Transmembrane segment M2 of the nicotinic cholinergic receptor channel is a key pore lining structure. J. Biol. Chem. 268, 14601-14607.

Reddy, LG., Iwamoto, T., Tomich, JM., and Montal, M. (1993) Synthetic peptides and four-helix bundle proteins as model systems for the pore-forming structure of channel proteins. III. Transmembrane segment M2 of the brain glycine receptor channel is a plausible candidate for the pore-lining structure. J. Biol. Chem. 268, 14608-14615.

Weiler, S., Carson, W., Lee, Y., Teplow, DB., Kishimoto, Y., O'Brien, JS., Barranger, JA., and Tomich, JM. (1993) Synthesis and characterization of a bioactive 82-residue sphingolipid activator protein, saposin C. J. Mol. Neurosci. 4, 161-172.

Montal, MO., Reddy, GL., Iwamoto, T., Tomich, JM., and Montal, M. (1994) Identification of an ion channel-forming motif in the primary structure of CFTR, the Cystic Fibrosis chloride channel. Proc. Natl. Acad. Sci. USA 91, 1495-1499.

Iwamoto, T., Grove, A., Montal, MO., Montal, M., and Tomich, JM. (1994) Chemical synthesis and characterization of peptides and oligomeric proteins designed to form transmembrane ion channels. Int. J. Peptide Protein Res. 43, 597-607.

Kanemitsu, H., Kirino, T., Nakagomi, T., Tsujita, Y., Iwamoto, T., Tomich, JM., and Tamura, A. (1994) Key of induced tolerance to ischaemia in gerbil hippocampal CA1 is not at trasncriptional level of hsp70 gene: In situ hybridization of hsp70 mRNA. Neurol. Res. 16, 209-212.

Tomich, JM., Grove, A., Iwamoto, T., Marrer, S., Montal, MS., and Montal, M. (1994) Design principles and chemical synthesis of oligomeric channel proteins. Chapter 15 in Advances in Chemistry Series No.235: Biomembrane Electrochemistry Eds. M.Blank and I. Vodyanoy, American Chemical Society, Washington D.C., pp.329-354. (A peer reviewed publication)

McCauley, LD., Park, CH., Lan, NC., Tomich, JM., Shively, JE., and Gee, KW. (1995) Benzodiazepines and peptides stimulate pregnenolone synthesis in brain mitochondria. Eur. J. Pharmacol. 276, 145-153.

Rajagopalan, S., Heck, TJ., Iwamoto, T., and Tomich, JM. (1995) Use of the 3-nitro-2-pyridine sulfenyl protecting group to introduce N-branching at lysine during solid-phase peptide synthesis: I. Application to the synthesis of a peptide template containing two addressable sites. Intl. J. Prot. Pept. Res. 45, 173-179.

Belogrudov, G., Tomich, JM., and Hatefi, Y. (1995) ATP synthase complex: Proximities of subunits in bovine submitochondrial particles. J. Biol. Chem. 270, 2053-2060.

Weiler, S., Kishimoto, Y., O'Brien, JS., Barranger, JA., and Tomich, JM. (1995) Identification of the binding and activating sites of the sphingolipid activator protein, saposin C with glucocerebrosidase. Prot. Sci. 4, 756-764.

Lee, Y., Kinoshita, H., Radke, G., Weiler, S., Barranger, JA., and Tomich, JM. (1995) Position of the sulyhydryl group and the disulfide bonds of human glucocerebrosidase. J. Prot. Chem. 14, 127-137.

O'Brien, JS., Carson, GS., Seo, H-C., Hiraiwa, M., Weiler, S., Tomich, JM., Barranger, JA., Kahn, M., Azuma, N., and Kishimoto, Y. (1995) Identification of the neurotrophic factor sequence of prosaposin. FASEB J. 9, 681-685.

Barranger, JA., Tomich, JM., Weiler, S., Sakallah, S., Sansieri, S., Mifflin, T., Bahnson, AB., Wei, F-S., Wei, J-F., Vallor, M., Nimgaonkar, M., Ball, E., Mohney, T., Dunigan, J., Ohashi, T., Bansal, V., Mannion-Henderson, J., Liu, C., and Rice, E. (1995) Molecular biology of glucocerebrosidase and the treatment of Gaucher disease. Cytokines and Molecular Therapy. 1, 149-163.

Rajagopalan, S., Radke, G., Evans, M., and Tomich, JM.(1996) Synthesis of N-t-boc-4-S-t-butyl-L-thiophenylalanine via palladium catalyzed cross-coupling reaction of N-t-boc-4-iodo-L-phenylalanine with sodium t-butylthiolate. Synthetic Comm. 26, 1431-1440.

Pandit, SD., Donis-Keller, H., Iwamoto, T., Tomich, JM., and Pike, LJ. (1996) The MEN 2B point mutation alters the transforming capacity of the EGF receptor. J. Biol. Chem. 271, 5850-5858.

Belogrudov, G., Tomich, JM., and Hatefi, Y. (1996) Mitochondrial ATP synthetase complex: membrane topography and location relative to other subunits of the small molecular weight subunits e, f and g. J. Biol Chem. 271 20340-20345.

Feinberg, BA., Lo, X., Iwamoto, T., and Tomich, JM. (1996) Synthetic mutants of Clostridium pasteurianum ferredoxin: Open iron sites and testing carboxylate coordination. Protein Engineering. 10, 101-107.

Rajagopalan, S., Radke, G., and Tomich, JM. (1997) A simple procedure for the preparation of 4-(-mercaptobenzyl)phenoxyacetic acid, a thiol linker unit used in solid phase synthesis of peptide--thioacids Synthetic Comm. 27, 187-194.

Christen,R., Jancic,T., Adams, MWW., Tomich, JM., and Smith E.T. (1997) Physical characterization of a totally synthetic rubredoxin. J. Inorg. Biochem. 65, 53-56.

Wallace, DP., Tomich, JM., Iwamoto, T., Henderson, K., Grantham, JJ., and Sullivan, LP. (1997) A synthetic peptide derived from the glycine-gated Cl- channel generates Cl- and fluid secretion by epithelial monolayers. Am. J. Physiol: 272 (Cell Physiol. 41) C1672-C1679.

Rajagopalan, S., Broughman, JR. Jr., Radke, G., and Tomich, JM. (1997) Studies on the palladium catalyzed synthesis of various N-protected 4-S-t-butyl-L-thiophenylalanine derivatives suitable for use in peptide synthesis. Current Topics in Peptide & Protein Research, 2, 159-168.

Tomich, JM., Wallace, DP., Henderson, K., Brandt, R., Ambler, CA., Scott, AJ., Mitchell, KE., Radke, G., Grantham, JJ., Sullivan, LP., and Iwamoto, T. (1998) Aqueous solubilization of transmembrane peptide sequences with retention of membrane insertion and function. Biophys J. 74, 256-267.

Tomich, JM., Iwamoto, T., and Sullivan, LP. (1998) Application of a synthetic chloride channel peptide for treatment of Cystic Fibrosis. Emerging Therapeutic Technologies , Vol 2 Ashley Publications Ltd. London, UK.

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Wallace, DP., Tomich, JM., Eppler, J., Iwamoto, T., Grantham, JJ., and Sullivan, LP. (2000) A Channel forming peptide induces Cl- secretion by T84 cells: Modulation by Ca2+ - dependent K+ channels. Biochim. Biophys. Acta 1464, 69-82.

Mitchell, KE., Tomich, JM., Iwamoto, T., and Freeman, LC. (2000) A synthetic peptide based on a glycine-gated chloride channel induces a novel chloride conductance in isolated epithelial cells. Biochim. Biophys. Acta 1466, 47-60.

Broughman, JR., Mitchell, K., Iwamoto,T., Schultz, BD., and Tomich, JM. (2001) Amino-terminal modification of a channel-forming peptide increases capacity for epithelia anion secretion. Am. J. Physiol: (Cell Physiol.) 280: C451-458.

Gao, L., Broughman, JR., Iwamoto, T., Tomich, JM., Venglarik, CJ., and Forman, HJ. (2001) Synthetic Cl- channel restores glutathione secretion in airway epithelia. Am.J.Physiol (Lung) 281: L24-L30.

Broughman, JR., Shank, LP., Takeguchi, W., Iwamoto, T., Mitchell, KE., Schultz, BD., and Tomich, JM. (2002) Distinct structural elements that direct solution aggregation and membrane assembly in the channel forming peptide M2GlyR. Biochemistry 41,7350-7358.

Broughman, JR., Shank, LP., Iwamoto, T., Prakash, O., Schultz, BD., Tomich, JM., and Mitchell, KE. (2002) Structural implications of placing cationic residues at either the NH2- or COOH- terminus in a pore-forming synthetic peptide. J Membrane Biol. 190: 93-103.

Matsumoto, N., Tsuruoka, S., Iwamoto, T., Tomich, JM., Ito, K., Imai, M., and Suzuki, M. (2003) Alterations in Ion Transport Induced by an Artificial Cl- Channel in Micro-Perfused Renal Proximal Tubules. J. Membr. Biol. 193:195-200.

Broughman, JR., Brandt, R., Hastings, C., Iwamoto, T., Tomich, JM., and Schultz, BD. (2004) Anion Channel-Forming Peptide Modulates Transepithelial Electrical Conductance and Solute Permeability. Am. J. Physiol: (Cell Physiol.) 286: C1312-1323.

Cook, GA., Prakash, O., Zhang, K., Shank, LP., Robbins, A., Gong, Y-X., Iwamoto, T., Schultz, BD., and Tomich, JM. (2004) Activity and Structural Comparisons of Solution Associating and Monomeric Channel-Forming Peptides Derived from the Glycine Receptor M2 Segment. Biophysical J. 86: 1424-1435.

Iwamoto, T., You, M., Li, E., Spangler, J., Tomich, J., and Hristova, K. (2005) Synthesis and initial characterization of FGFR3 transmembrane domain: Consequences of sequence modifications. Biochim.Biophys.Acta-Biomembranes 1668:240-247.

Xinchun Shen, Robyn Moore, Xiaoqun Mo, Shawnalea J. Frazier, Takeo Iwamoto, John M. Tomich, X Susan Sun (2006) Novel pH Dependent Adhesive Peptides. In press J. Nanoscience and Nanotechnology

Shank, LP., Broughman, JR., Brandt RM., Robbins, AS., Takeguchi, W., Cook, GA., Hahn, L., Radke, G., Iwamoto, T., Schultz, BD., and Tomich, JM. (2006) Redesigning Channel-Forming Peptides: Amino Acid Substitutions in Channel-Forming Peptides that Enhance Rates of Supramolecular Assembly and Raise Ion Transport Activity. In press Biophys. J.

Johnston, JM., Cook, GA., Tomich, JM., and Samson, MS. (2006) Conformation And Environment Of Channel Forming Peptides: A Simulation Study. In press Biophys J.

Cook, GA., Pajewski, R., Aburi, M., Smith, PE., Prakash, O., Tomich, JM., and Gokel, GW. (2006) NMR Structure and Dynamic Studies of an Anion Binding Channel-Forming Heptapeptide. In press. J. Amer. Chem Soc.

van Ginkel, FW., Iwamoto, T., Schultz, BD., and Tomich, JM. (2008) Immunity to Self-derived, Channel-Forming Peptides in the Respiratory Tract. Clinical and Vaccine Immunology. 15(2):260-266. PMID: 18094111.

Mo, X., Hiromasa, Y., Al-Rawi, A., Warner, M., Iwamoto, T., Rahman, T., Sun, X., and Tomich, JM. (2008) Design of 11-Residue Peptides with Unusual Biophysical Properties: Induced Secondary Structure in the Absence of Water. Biophysical J. 94:1807-1817. PMID: 18024497.

Zhang, Y., Iwamoto, T., Tomich, JM., Kariya, Y., Suzuki, K., Conrad, AH., and Conrad, GW. (2008) On-target derivatization of keratan sulfate oligosaccharides with phyrenebutyric acid hydrazide for MALDI-TOF/TOF-MS. J. Mass Spectrom. 43(6):765-772. PMID: 18205237.

Somasekharan, S., Brandt, R., Iwamoto, T., Tomich, JM., and Schultz, BD. (2008) Modulation of Epithelial Barrier Function by a Synthetic Peptide. J. Membr. Biol. 222: 17-30. PMID: 18418541.

Seo, G-M., Cheng, C., Tomich, JM., and Ganta, RR. (2008) Total, membrane, and immunogenic proteomes of macrophage- and tick cell-derived Ehrlichia chaffeensis evaluated by LC-MS/MS and MALDI-TOF methods. Infection and Immunity. 76: 4823-4832. PMID: 18710870.

Martin, J., Devlin, S., Malreddy, P., Iwamoto, T., Freeman, L., Davidson, H., Tomich, JM., and Schultz, BD. (2009) NC-1059, A Channel-Forming Peptide Modulates Drug Delivery Across In Vitro Corneal Epithelium. Invest. Ophthal. Vis Sci. 50(7):3337-3345. PMID: 19234338.

Thomas, VC., Hiromasa, Y., Harms, N., Thurlow, L., Tomich, J., and Hancock, L. (2009) A fratricidal mechanism is responsible for eDNA release and contributes to biofilm development of Enterococcus faecalis . Molecular Microbiology. 72(4):1022-1036. PMID: 19400795.

Morris, K., Lorenzen, M., Hiromasa, Y., Tomich, JM., Oppert, C., Elpidina, EN., Vinokurov, K., Jurat-Fuentes, JL., Fabrick, J., and Oppert, BS. (2009) The Tribolium castaneum larval gut transcriptome and proteome: A resource for the study of the coleopteran gut. J Proteome Res. 8(8):3889-3898. PMID: 19545177.

Marshall, JL., Huestis, DL., Hiromasa, Y., Oppert, C., Marshall, SA., Tomich, JM., and Oppert, B. (2009) Identification, RNAi knockdown, and functional analysis of an ejaculate protein that mediates a postmating, prezygotic phenotype in a cricket. PLoS ONE 4(10):e7537 (10 pgs). PMID: 19851502.

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Tomich, JM., and Takemoto, D. (2010) Molecules and Society. eBook. Kendall Hunt Publishing Co, Dubuque, IA. ISBN 978-1-61549-121-6.

Davis, L., Ragan, E., Takemoto, D., and Tomich, J. (2010) Molecules & Society Laboratory Manual. Kendall Hunt Publishing Co, Dubuque, IA, 124 pp. ISBN 978-1-61549-123-0.

Herrera, AI., Al-Rawi, A., Cook GA., Prakash, O., Tomich, JM., and Chen, J. (2010) Structural characterization of two pore-forming peptide: consequences of introducing a C-terminal tryptophan. PROTEINS: Structure, Function, and Genetics 78(10):2238-50. PMC2909830

Cruz, JC., Pfromm, PF., Tomich, JM., and Rezac, ME. (2010) Conformational Changes of Hydrolases Adsorbed on Fumed Silica Nanoparticles: I. Tertiary Structure. Colloids and Surfaces B: Biointerfaces 79(1):97-104. PMID: 20434319.

Cruz, JC., Pfromm, PF., Tomich, JM., and Rezac, ME. (2010) Conformational Changes and Catalytic Competency of Hydrolases Adsorbing on Fumed Silica Nanoparticles: II. Secondary Structure. Colloids and Surfaces B: Biointerfaces Jun 17. [Epub ahead of print] PMID: 20638251.

Marshall, JL., Huestis, DL., Garcia, C., Hiromasa, Y., Wheeler, S., Noh, S., Tomich, JM., and Howard, DJ. (2010) Comparative proteomics uncovers the signature of natural selection acting on the ejaculate proteomes of two cricket species isolated by postmating, prezygotic phenotypes. Molecular Biology and Evolution Aug 30. [Epub ahead of print] PMID: 20805188.

Fleming SD., Pope, MR., Hoffman, SM., Moses, T., Bukovnik, U., Tomich, JM., Wagner, L., and Woods, KM. (2010) Domain V peptides inhibit b2-glycoprotein I mediated mesenteric ischemia/reperfusion-induced tissue damage and inflammation. In press. J. Immunol.

Bukovnik, U., Gao, J., Cook, GA., Shank, LP., Seabra, MB., Schultz, BD., Iwamoto, T., Chen, J., and Tomich, JM. (2011) Structural and biophysical properties of a synthetic channel-forming peptide: Designing a clinically relevant anion selective pore Biochim, Biophys. Acta Jul 31. [Epub ahead of print]. PMID: 21835162

Tomich, JM., Bukovnik, U., Layman JS., and Schultz, BD. (2012) Channel Replacement Therapy for Cystic Fibrosis in "Cystic Fibrosis", InTech - Open Access Publisher ISBN 979-953-307-059-8.

Dittmer, NT., Hiromasa, Y., Tomich, JM., Lu, N., Beeman, RW., Kramer, KJ., and Kanost, MR. (2012) Proteomic and transcriptomic analyses of rigid and membranous cuticles from the elytra and hindwings of the red flour beetle, Tribolium castaneum . Journal of Proteome Research. 11, 269-278.

Gudlur, S., Sukthankar, P., Gao, J. Avila, L.A., Hiromasa, Y., Chen, J., Iwamoto, T., Tomich, J.M. (2012) Peptide Nanovesicles Formed by the Self-Assembly of Branched Amphiphilic Peptides. PLOS ONE. 7 (9) e45374 pages 1-11 PMC3445502

Sukthankar, P., Gudlur, S., Avila, L.A., Whitaker, S., Katz, B.B., Hiromasa, Y., Gao, J., Thapa, P., Moore, D., Iwamoto, T., Tomich, J.M. (2013) Branched Oligopeptides Form Nano-Capsules with Lipid Vesicle Characteristics Langmuir 29:14648−14654. PMC3889211

Sukthankar, P., Avila, LA., Whitaker, SK., Iwamoto, T., Morgenstern, A., Apostolidis, C., Liu, K., Hanzlik, RP., Dadachova, E., and Tomich, JM. (2014) Branched Amphiphilic Peptide Capsules: Cellular Uptake and Retention of Encapsulated Solutes. Biochim, Biophys. Acta, Biomembranes 1838: 2296-2305. PMID: 24565797.

Chen, J., and Tomich, JM. (2014) Free Energy Analysis of Conductivity and Charge Selectivity of M2GlyR-Derived Synthetic Channels. Biochim, Biophys. Acta, Biomembranes 2014 Sep; 1838 (9):2319-25. PMID: 24582709.

Varahan, S., Harms, N., Gilmore, MS., Tomich, JM., and Hancock, LE. (2014) An ABC Transporter Is Required for Secretion of Peptide Sex Pheromones in Enterococcus faecalis. MBio. Sep 23;5(5). pii: e01726-14. doi: 10.1128/mBio.01726-14.

Avila, L.A, Lee, S. and Tomich J.M. (2014) “Synthetic in vitro delivery systems for plasmid DNA in eukaryotes” (review) J. Nanopharmaceutics and Drug Delivery 2: 17-35.

Chen, C., Cao, R., Shrestha, R., Ward, C., Katz, B., Fischer, C., Tomich, J.M., Li, P. Trapping of Intermediates with Substrate Analog HBOCoA in the Polymerizations Catalyzed by Class III Polyhydroxybutyrate (PHB) Synthase from Allochromatium Vinosum ACS Chem Biol. 2015 May 15; 10(5): 1330-9. doi: 1021/cb5009958. Epub 2015 Feb 25. PMID: 25686368.

Cui, F., Wang,W., Zhang, Y., Dai, H., Raman, C., Hiromasa, Y., Peng,G., Chen, X., Tomich, J., Reese, J., Edwards, O., Reeck, G. (2015) The protein Armet/MANF is responsive to endoplasmic reticulum stress in insects. FASEB J [Epub ahead of print] PMID: 25678626

Avila, L.A., Aps, L. R. M. M., Sukthankar, P., Ploscariu, N., Gudlur, G., Šimo,L. Szoszkiewicz, R., Park, Y., Lee, S. W., Iwamoto, T., Ferreira, L., Tomich, J. M. (2015) Alternate supramolecular structures for different ratios of branched amphiphilic cationic peptide /DNA assemblies: Correlation with gene delivery. Mol Pharm. 12(3):706-15. PMID: 25647162

Chen, C., Cao, R., Shrestha, R., Ward, C., Katz, B., Fischer, C., Tomich, J.M., Li, P. (2015) Trapping of Intermediates with Substrate Analog HBOCoA in the Polymerizations Catalyzed by Class III Polyhydroxybutyrate (PHB) Synthase from Allochromatium Vinosum. ACS Chem Biol. Feb 16. [Epub ahead of print] PMID: 25686368.

Sukthankar, P, Whitaker, S.K., Garcia, M., Herrera, A., Boatwright, M., Prakash, O., and Tomich, J.M. (2015) Thermally Induced Conformational Transitions in Nascent Branched Amphiphilic Peptide Capsules. Langmuir. 2015 Mar 17;31(10):2946-55. doi: 10.1021/la504381y. Epub 2015 Mar 6. PMID: 2571959

Barros, S. M., Whitaker, S. K., Sukthankar, P. R., Gudlur, S., Warner, M. Beltrão, E. I. C., Tomich, J.M. (2016) A Review of Solute Encapsulating Nanoparticles used as Delivery Systems with Emphasis on Branched Amphipathic Peptide Capsules. Arch Biochem Biophys. 596: 22-42. PMID: 26926258

Su, X., Xu, J., Rhodes, D., Shen, Y., Song, W., Katz, B. Tomich, J. M. Wang, W. (2016) Identification and Quantification of Anthocyanins in Transgenic Purple Tomato. Food Chemistry 202: 184-188. PMID: 26920283

Guo, R., Katz, B.B. Tomich, J.M., Gallagher, T.,Fang, Y. (2016) Porcine reproductive and respiratory syndrome virus utilizes nanotubes for intercellular spread. J Virol. Mar 16. [Epub ahead of print] PMID: 26984724

Herrera, A.I., Tomich, J.M., Prakash O. (2016) Membrane Interacting Peptides: A Review. Current Protein & Peptide Science In press.

Jia, Z., Whitaker, S.K., Tomich, J. M., Chen, J. (2016) Organization and Structure of Branched Amphipathic Oligopeptide Bilayers. Langmuir 32: 9883–9891. PMID: 27584835

Avila, L.A., Aps, L. R. M. M., Sukthankar, P., Ploscariu, Games, P.D., Whitaker, S.K., Fang, Y., Szoszkiewicz, R., Ferreira, L.C.S., Tomich, J. M. (2016) Branched amphiphilic cationic oligo-peptides for delivery of plasmid DNA vaccines. J. Contrl Release. 241:15-24. doi: 10.1016/j.jconrel.2016.08.042. PMID: 27592740

Obasa, K., Fellers, J. Kennelly, M., Katz, B., Tomich, J., Liu, S., Moore, D., Shinogle, H., Kelley, K., White, F. F. (2017) A dimorphic and virulence-enhancing endosymbiont bacteria discovered in Rhizoctonia solani. Phytobiome. 1(1) 14-23.

Teixeira, A. D., Games, P.D., Tomich, J. M., Katz, B. B., Zanuncio, J. C., Serrao, J. E. (2017) Proteomic analysis of the Dufour's gland in nurse and forager workers of the honey bee Apis mellifera (Hymenoptera: Apidae) PLOS ONE 12(5): e0177415. PMID: 28542566

Barros, S. M., Avila, L. A., Whitaker, S. K., Sukthankar, P., Beltrão, E. I. C., Tomich, J. M. (2017) Branched Amphipathic Peptide Capsules: Different Ratios of the Two Constituent Peptides Direct Distinct Bilayer Structures and Sizes. Langmuir. 33(28):7096-7104. doi: 10.1021/acs.langmuir.7b00912. PMID:28654272

Avila, L.A., Chandrasekar, R., Wilkinson, K. E. Balthazor, J., Herman, M., Bechard, J., Brown, S., Park, Y., Dhar, S., Reeck, G.R., Tomich, J. M. Delivery of lethal dsRNAs in insect diets by Branched Amphiphilic Peptide Capsules. J. Control Release (2018) 273, 139-146. doi: 10.1016/j.jconrel.2018.01.010. PMID:29407675

Natarajan, P., Sukthankar, P., Changstrom, J., Holland, C. S., Barry., Hunter W. D., Sorensen, C. M., Tomich, J. M. (2018) Self-Assembling Branched Amphiphilic Peptide Bilayers: Characterization of multifunctional complexes on gold and magnetic nanoparticles. ACS Omega, 3 (9), 11071-11083 DOI: 10.1021/acsomega.8b01633

Hunter, W. B., Gonzalez, M. T., Tomich, J. M. (2018) BAPC-assisted CRISPR/Cas9 System: Targeted Delivery into Adult Ovaries for Heritable Germline Gene Editing (Arthropoda: Hemiptera) bioRxiv 478743;

Delimont, N. M., Katz. B. B., Fiorentino, N. M., Kimmel, K. A., Haub, M. D., Rosenkranz, S. K., Tomich, J. M., Lindshield, B. L. (2019) Salivary Cystatin SN Binds to Phytic Acid In Vitro and Is a Predictor of Nonheme Iron Bioavailability with Phytic Acid Supplementation in a Proof of Concept Pilot Study. Curr Dev Nutr. 3(7):nzz057. doi: 10.1093/cdn/nzz057. eCollection 2019 Jul.

Wessel, E. M., Tomich, J. M., Todd, R. B. (2019) Biodegradable Drug-Delivery Peptide Nano-Capsules ACS-Omega 2019 10.1021/acsomega.9b03245. PMID:31788640

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Natarajan, P., Roberts, J., Kunte, N., Hunter, W. B., Fleming, S., Tomich, J. M., Avila, L. A. (2020) Cellular Uptake Mechanisms Of Branched Amphiphilic Peptide Capsules Probed with Hollow Water Filled and Magnetic Core Nanospheres. Mol Pharm. 17(6) 2208–2220 doi: 10.1021/acs.molpharmaceut.0c00393. PMID: 32324415

Smalley, H., Rowe, J. M., Nieto, F., Zeledon, J., Pollard, K., Tomich, J. M., Fleming, S.D. (2020) Beta2 Glycoprotein I Derived Therapeutic Peptides Induce sFLT-1 Secretion to Reduce Melanoma Vascularity and Growth. Cancer Letters

Natarajan, P., Tomich, J. M. (2020) Bio-Interactions of Gold and Iron Oxide Nanoparticles : The Role of Experimental Parameters on in vitro and in vivo Interactions Arch. Biochem. Biophys. 694,108592

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Book chapters

Shon, K., Schrader, P., Opella, S., Richards, J. and Tomich, J. M. (1990) NMR spectra of synthetic membrane bound coat protein species. UCLA Symposium on Molecular and Cellular Biology, New Series, 109 ed. D. Live, I. Armitage, and D. Patel, Alan R. Liss, Inc., New York, New York, pp.109-118.

Grove, A., Iwamoto, T., Montal, M. S., Reddy, G. L., Marrer, S., Tomich, J. M. and Montal, M. (1992) Towards a unifying structural motif for the pore-forming structure of channel proteins. In: "Biotechnology of Cell Regulation", Vol. 4, R. Verna and Y. Nishizuka (eds.), pp. 89-102.

Grove, A., Iwamoto, T., Montal, M. S., Tomich, J. M. and Montal, M. (1992) Synthetic peptides and proteins as models for the pore-forming structure of channel proteins. Methods in Enzymology: Ion Channels, vol. 207, 510-525, B. Rudy and L. E. Iverson (eds.), Academic Press.

Tomich, J. M. and Richards, J. H. (1992) Synthetic metalloproteins. In: "Peptides: Chemistry and Biology", J. A. Smith and J. E. Rivier (eds.), Escom, Leiden, pp. 331-332.

Grove, A., Iwamoto, T., Montal, M. S., Tomich, J. M. and Montal, M. (1992) Design and synthesis of 4-helix bundle channel proteins. In: "Peptides: Chemistry and Biology", J. A. Smith and J. E. Rivier (eds.), Escom, Leiden, pp. 329-331.

McCauley, L. D., Lan, N. C., Tomich, J. M., Shively, J. E.and Gee, K. W. (1992) Peripheral-type benzodiazepine receptors and the regulation of steroidogenesis in rat brain mitochondria. In: "Advances in Biochemical Psychopharmacology," GABAergic Synaptic Transmission 47, 143-147.

Grove, A., Montal, M. S., Reddy, G. L., Marrer, S., Iwamoto, T., Tomich, J. M. and Montal, M. (1992) Channel proteins: From anatomy to design. Jerusalem Symposium, Klumer Academic, Dordrecht, Netherlands, A. Pullman (ed.). In: Membrane Proteins: Structures Interactions and Models, pp. 249-268.

Grove, A., Tomich, J. M. and Montal, M. (1992) Molecular design of oligomeric channel proteins. In: Genetic Engineering, Principles and Methods, Vol. 14, Setlow, J. K.(ed.), Plenum Press, pp. 163-184.

Tomich, J.M. Channel forming amphipathic helices. (1993) In: "The Amphipathic Helix", CRC Press Inc., Boca Raton, R. Epand (ed.), Chap. 9, pp. 221-254.

Grove, A., Tomich, J. M., Iwamoto, T. and Montal, M. (1995) Molecular design of a dihydropuridine-sensitive calcium channel protein. "Symposium on Ca2+ antagonists in CNS", A. Scriabine.

Tomich, J. M., Bukovnik, U., Layman J.S., Schultz B.D. (2012) Channel Replacement Therapy for Cystic Fibrosis in "Cystic Fibrosis - Renewed Hopes Through Research", Dinesh Sriramulu ed. Chapter 13 pp 291-332. InTech - Open Access Publisher (Rijeka, Croatia) ISBN 979-953-307-059-8.

Tomich, J. M. Wessel, E., Choi, J., Avila, L. A. (2019) Peptiplexes-A Review of Therapeutic Applications. In “Nucleic Acid Nanotheranostics: Biomedical Applications” Marco Filice and Jesus Ruiz-Cabello eds, Elsevier Publishing (Amsterdam, Netherlands) pp 247-276. ISBN-13 : 978-0128144701

Hunter, W.B., Clarke, S.V., Sandoval Mojica, A.F., Paris, T., Metz, J.L., Holland, C.S., McCollum, G., Miles, G., Tomich, J.M., Boyle, M.J., Qureshi, J.A., Cano, L., Altman, S., Cano, L., Pelz-Stelinski, K.S. (2020) Advances in RNA suppression of the Asian Citrus Psyllid Vector of bacteria (Huanglongbing Pathosystem). In Asian Citrus Psyllid. Biology, Ecology and Management of the Huanglongbing Vector. Chapt. 17. 352 pages. In Asian Citrus Psyllid. Biology, Ecology and Management of the Huanglongbing Vector. (eds) Phil Stansly and Jawwad Qureshi. Commonwealth Agricultural Bureau International (CABI Press). p. 258-283. ISBN 978-178-639-408-8

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Patents issued

Tomich, J. M. and Montal, M. (1994) Biologically Mimetic Synthetic Ion Channel Transducers. U. S. Patent # 5,368,712— issued November 29, 1994.

Tomich, J. M. and Iwamoto, T. (1999) Methods for Purifying Synthetic Peptides.

U. S. Patent # 5,922,840— issued July 13, 1999.

Tomich, J.M., Iwamoto, T. and Sullivan, L (2000). Synthetic Macromolecular Channel Assembly for Transport of Chloride Ions Through Epithelium Useful for Treating Cystic Fibrosis U. S. Patent # 6,077,826— issued June 20, 2000.

Tomich, J.M., Iwamoto, T., Broughman, J.R., and Schultz, B.D. M2GlyR Derived Channel Forming Peptides U. S. Patent # 6,750,200 B1— issued June 15, 2004.

Tomich, JM., Iwamoto, T., Hiromasa, Y., and Gudlur, S. (2010) “Branched Amphipathic Oligo-Peptides that Self- Assemble into Vesicles.” Notice of Allowance dated September 3, 2014

Fleming S.D. and Tomich, J. M., (submitted 2010) b2-Glycoprotein I Peptide Inhibitors. U.S. provisional patent Serial No. 61/379,257 filed July 13, 2010. Notice of Allowance dated September 15, 2014

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