Department of Biochemistry & Molecular Biophysics
141 Chalmers Hall
Manhattan, KS 66506
785-532-6121
785-532-7278 fax
biochem@k-state.edu



Biotechnology Core Facility
206 Burt Hall
785-532-5956
785-532-6297 fax



Biomolecular NMR Facility
37 Chalmers Hall
785-532-2345

Anna Zolkiewska, Ph.D., Associate Professor
Advisor

Complete Publications List

2010s | 2000s | 1990s

2010s

Ngansop, F., Li, H., Zolkiewska, A., and Zolkiewski, M. (2013) Biochemical characterization of the apicoplast-targeted AAA+ ATPase ClpB from Plasmodium falciparum. Biochem. Biophys. Res. Comm., in press

Duhachek Muggy, S., Li, H., Qi, Y., and Zolkiewska, A. (2013) Alternative mRNA splicing generates two distinct ADAM12 prodomain variants. PLOS ONE, in press

Li, H., Duhachek Muggy, S.,Zolkiewska, A. (2013) Metalloproteinase-disintegrin ADAM12 is associated with a breast tumor-initiating cell phenotype. Breast Cancer Res. Treat. 139, 691-703

Li, H, Duhachek-Muggy, S., Qi, Y., Hong, Y., Behbod, F., Zolkiewska, A. (2012) An essential role of metalloprotease-disintegrin ADAM12 in triple-negative breast cancer, Breast Cancer Res. Treat., 135, 759-769.

Chen J, Zolkiewska A. (2011) Force-induced unfolding simulations of the human Notch1 negative regulatory region: possible roles of the heterodimerization domain in mechanosensing. PLoS One 6(7):e22837.

Li H, Solomon E, Duhachek Muggy S, Sun D, Zolkiewska A. (2011) Metalloprotease-disintegrin ADAM12 expression is regulated by Notch signaling via microRNA-29. J. Biol. Chem. 286, 21500-21510.

Fukada S, Yamaguchi M, Kokubo H, Ogawa R, Uezumi A, Yoneda T, Matev MM, Motohashi N, Ito T, Zolkiewska A, Johnson RL, Saga Y, Miyagoe-Suzuki Y, Tsujikawa K, Takeda S, Yamamoto H. (2011) Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers. Development 138, 4609-4619.

Solomon E, Li H, Duhachek Muggy S, Syta E, Zolkiewska A. (2010) The role of SnoN in transforming growth factor beta1-induced expression of metalloprotease-disintegrin ADAM12. J. Biol. Chem. 16, 285, 21969-21977.

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2000s

Sun, D., Li, H., and Zolkiewska, A. (2008) The role of Delta-like 1 shedding in muscle cell self-renewal and differentiation. J. Cell Sci.121, 3815-3823.

Dyczynska, E., Syta, E., Sun, D., and Zolkiewska, A. (2008) Breast cancer-associated mutations in metalloprotease disintegrin ADAM12 interfere with the intracellular trafficking and processing of the protein. Int. J. Cancer 122, 2634-2640.

Zolkiewska, A. (2008) ADAM proteases: ligand processing and modulation of the Notch pathway. Cell. Mol. Life Sci. 65, 2056-2068.

Dyczynska, E., Sun, D., Yi, H., Sehara-Fujisawa, A., Blobel, C. P., and Zolkiewska, A. (2007) Proteolytic processing of Delta-like 1 by ADAM proteases. J. Biol. Chem. 282, 436-444.

Yi, H., Gruszczynska-Biegala, J., Wood, D., Zhao, Z., and Zolkiewska, A. (2005) Cooperation of the metalloprotease, disintegrin and cysteine-rich domains of ADAM12 during inhibition of myogenic differentiation. J. Biol. Chem., 280, 23475-23483.

Zhao, Z., Gruszczynska-Biegala, J., and Zolkiewska, A. (2005) ADP-ribosylation of integrin a7 modulates the binding of integrin a7b1 to laminin. Biochem. J. 385, 309-317.

Zolkiewska, A. (2005) Ecto-ADP-ribose transferases: cell-surface response to local tissue injury. Physiology 20, 374-381.

Zhao, Z., Gruszczynska-Biegala, J., Cheuvront, T., Yi, H., Von Der Mark, H., Von Der Mark, K., Kaufman, S. J., and Zolkiewska, A. (2004) Interaction of the disintegrin and cysteine-rich domains of ADAM12 with integrin a7b1. Exp Cell Res. 298, 28-37.

Cao, Y., Zhao, Z., Gruszczynska-Biegala, J., and Zolkiewska, A. (2003) Role of metalloprotease disintegrin ADAM12 in determination of quiescent reserve cells during myogenic differentiation in vitro. Mol. Cell. Biol. 23, 6725-6738 .

Liu, Z., Zolkiewska, A., and Zolkiewski, M. (2003) Characterization of human torsinA and its dystonia-associated mutant form. Biochem. J., 374, 117-122 .

Cao, Y., Kang, Q., Zhao, Z., and Zolkiewska, A. (2002) Intracellular Processing of Metalloprotease Disintegrin ADAM12. J. Biol. Chem. 277, 26403-26411.

Kang, Q., Cao, Y., and Zolkiewska, A. (2001) Direct interaction between the cytoplasmic tail of ADAM 12 and the SH3 domain of p85a activates phosphatidylinositol 3-kinase in C2C12 cells. J. Biol. Chem. 276, 24466-24472.

Cao, Y., Kang, Q., and Zolkiewska A. (2001) Metalloprotease-disintegrin ADAM12 interacts with a-actinin-1. Biochem. J. 357, 353-361.

Kang, Q., Cao, Y., and Zolkiewska, A. (2000) Metalloprotease-disintegrin ADAM12 binds to the SH3 domain of Src and activates Src tyrosine kinase in C2C12 cells. Biochem. J. 352, 883-892.

Barnett, M. E., Zolkiewska, A., and Zolkiewski, M. (2000) Structure and activity of ClpB from Escherichia coli: role of the amino- and carboxy-terminal domains. J. Biol. Chem. 275, 37565-37571.

Iba, K., Albrechtsen, R., Gilpin, B., Fröhlich, C., Loechel, F., Zolkiewska, A., Ishiguro, K., Kojima, T., Liu, W., Langford, J. K., Sanderson, R. D., Brakebusch, C., Fässler, R., and Wewer, U. M. (2000) The cysteine-rich domain of human ADAM12 supports cell adhesion through syndecans and triggers signaling events that leads to integrin b1-dependent cell spreading. J. Cell Biol., 149, 1143-1155.

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1990s

Zolkiewska, A. (1999) Disintegrin-like/cysteine-rich region of ADAM12 is an active cell adhesion domain. Exp. Cell Res. 252, 423-431 .

Moss, J., Balducci, E., Cavanaugh, E., Kim, H. J., Konczalik, P., Lesma, E. A., Okazaki, I. J., Park, M., Schoemaker, M., Stevens, L. A., and Zolkiewska, A. (1999) Characterization of NAD:arginine ADP-ribosyltransferases. Mol. Cell. Biochem. 193, 109-113.

Zolkiewska, A., Thompson, W. C., and Moss, J. (1998) Interaction of integrin a7b1 in C2C12 myotubes and in solution with laminin. Exp. Cell Res. 240, 86‑94 .

Moss, J., Zolkiewska, A., and Okazaki, I. J. (1997) ADP-ribosylarginine hydrolases and ADP-ribosyltransferases: Partners in ADP-ribosylation cycles. Adv.Exp. Med. Biol. 419, 25-33.

Zolkiewska, A., and Moss, J. (1997) The a7 integrin as a target protein for cell surface mono-ADP-ribosylation in muscle cells. Adv.Exp. Med. Biol. 419, 297-303.

Zolkiewska, A., and Moss, J. (1995) Processing of ADP-ribosylated integrin a7 in skeletal muscle myotubes. J. Biol. Chem. 270, 9227-9233.

Okazaki, I. J., Zolkiewska, A., Takada, T., and Moss, J. (1995) Characterization of mammalian ADP-ribosylation cycles. Biochimie 77, 319-325.

Zolkiewska, A., Okazaki, I. J., and Moss, J. (1994) Vertebrate ADP-ribosyltransferases. Mol. Cell. Biochem. 138, 107-112.

Okazaki, I. J., Zolkiewska, A., Nightingale, M. S., and Moss, J. (1994) Immunological and structural conservation of mammalian skeletal muscle glycosylphosphatidylinositol-linked ADP-ribosyltransferases. Biochemistry 33, 12828-12836.

Zolkiewska, A., and Moss, J. (1993) Integrin a7 as substrate for a glycosylphosphatidyl-inositol-anchored ADP-ribosyltransferase on the surface of skeletal muscle cells. J. Biol. Chem. 268, 25273-25276.

Zolkiewska, A., Nightingale, M. S., and Moss, J. (1992) Molecular characterization of NAD:arginine ADP-ribosyltransferase from rabbit skeletal muscle. Proc. Natl. Acad. Sci. USA 89, 11352-21356.

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