Department of Biochemistry & Molecular Biophysics
141 Chalmers Hall
Manhattan, KS 66506
785-532-6121
785-532-7278 fax
biochem@k-state.edu



Biotechnology Core Facility
206 Burt Hall
785-532-5956
785-532-6297 fax



Biomolecular NMR Facility
37 Chalmers Hall
785-532-2345

John Tomich, Ph.D., Professor
Director of Biotechnology/Proteomics Core Facility, Advisor

Image of John Tomich, Ph.D.

Contact information

Office: 206 Burt Hall
Phone: 785-532-5956
Fax: 785-532-6297
E-mail: jtomich@ksu.edu
Lab website: www.k-state.edu/bmb/labs/biotech/group

Education

B.A. 1974, University of Connecticut
M.S. 1975, Purdue University
Ph.D. 1980, University of Waterloo

Areas of specialty

The Tomich laboratory designs and characterizes synthetic peptides for potential uses as drugs or renewable biomaterials. The lab employs a number of biologic, synthetic, analytic and physical methods to make these characterizations.

Read detailed research description

Selected publications

Tomich, J. M., Bukovnik, U., Layman J. S., Schultz B. D. (2012) Channel Replacement Therapy for Cystic Fibrosis in "Cystic Fibrosis", InTech - Open Access Publisher ISBN 979-953-307-059-8.

Bukovnik, U., Gao, J., Cook, G. A., Shank, L. P., Seabra, M. B., Schultz, B. D., Iwamoto, T., Chen, J., Tomich, J. M. (2011) Structural and biophysical properties of a synthetic channel-forming peptide: Designing a clinically relevant anion selective pore Biochim, Biophys. Acta Jul 31. [Epub ahead of print]. PMID: 21835162

Herrera, A. I., Al-Rawi, A., Cook G. A., Prakash, O., Tomich, J. M., and Chen, J. (2010) Introduction of a C-Terminal Tryptophan in a Pore-Forming Peptide: A Structure/Activity Study. PROTEINS: Structure, Function, and Genetics 78(10):2238-2250. PMC2909830

Martin, J., Devlin, S., Malreddy, P., Iwamoto, T., Freeman, L., Davidson, H., Tomich, J. M., and Schultz, B. D. (2009) NC-1059, A Channel-Forming Peptide Modulates Drug Delivery Across In Vitro Corneal Epithelium. Invest. Ophthal. Vis. Sci. 50(7):3337-3345. PMID: 19234338

Somasekharan, S., Brandt, R., Iwamoto, T., Tomich, J. M., and Schultz, B. D. (2008) Modulation of Epithelial Barrier Function by a Synthetic Peptide. J. Membr. Biol. 222: 17-30. PMID: 18418541

van Ginkel, F. W., Iwamoto, T., Schultz, B. D., and Tomich, J. M. (2008) Peptide-Specific Immunity to Self-derived, Anion Channel-Forming Peptides in the Respiratory Tract. Clinical and Vaccine Immunology 15(2):260-266. PMID: 18094111

Mo, X., Hiromasa, Y., Al-Rawi, A., Warner, M. Iwamoto, T., Rahman, T., Sun, X., and Tomich, J. M. (2008) Design of 11-Residue Peptides with Unusual Biophysical Properties: Induced Secondary Structure in the Absence of Water. Biophysical J. 94:1807-1817. PMID: 18024497

Johnston, J. M., Cook, G. A., Tomich, J. M., and Sansom, M. S. (2006) Conformation And Environment Of Channel Forming Peptides: A Simulation Study. Biophys J. 90:1855-1864.

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