John Tomich, Ph.D., Professor
Director of Biotechnology/Proteomics Core Facility, Advisor
 Contact informationOffice: 206 Burt Hall EducationB.A. 1974, University of Connecticut |
Areas of specialty
The Tomich laboratory designs and characterizes synthetic peptides for potential uses as drugs or renewable biomaterials. The lab employs a number of biologic, synthetic, analytic and physical methods to make these characterizations.
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Selected publications
Tomich, J. M., Bukovnik, U., Layman J. S., Schultz B. D. (2012) Channel Replacement Therapy for Cystic Fibrosis in "Cystic Fibrosis", InTech - Open Access Publisher ISBN 979-953-307-059-8.
Bukovnik, U., Gao, J., Cook, G. A., Shank, L. P., Seabra, M. B., Schultz, B. D., Iwamoto, T., Chen, J., Tomich, J. M. (2011) Structural and biophysical properties of a synthetic channel-forming peptide: Designing a clinically relevant anion selective pore Biochim, Biophys. Acta Jul 31. [Epub ahead of print]. PMID: 21835162
Herrera, A. I., Al-Rawi, A., Cook G. A., Prakash, O., Tomich, J. M., and Chen, J. (2010) Introduction of a C-Terminal Tryptophan in a Pore-Forming Peptide: A Structure/Activity Study. PROTEINS: Structure, Function, and Genetics 78(10):2238-2250. PMC2909830
Martin, J., Devlin, S., Malreddy, P., Iwamoto, T., Freeman, L., Davidson, H., Tomich, J. M., and Schultz, B. D. (2009) NC-1059, A Channel-Forming Peptide Modulates Drug Delivery Across In Vitro Corneal Epithelium. Invest. Ophthal. Vis. Sci. 50(7):3337-3345. PMID: 19234338
Somasekharan, S., Brandt, R., Iwamoto, T., Tomich, J. M., and Schultz, B. D. (2008) Modulation of Epithelial Barrier Function by a Synthetic Peptide. J. Membr. Biol. 222: 17-30. PMID: 18418541
van Ginkel, F. W., Iwamoto, T., Schultz, B. D., and Tomich, J. M. (2008) Peptide-Specific Immunity to Self-derived, Anion Channel-Forming Peptides in the Respiratory Tract. Clinical and Vaccine Immunology 15(2):260-266. PMID: 18094111
Mo, X., Hiromasa, Y., Al-Rawi, A., Warner, M. Iwamoto, T., Rahman, T., Sun, X., and Tomich, J. M. (2008) Design of 11-Residue Peptides with Unusual Biophysical Properties: Induced Secondary Structure in the Absence of Water. Biophysical J. 94:1807-1817. PMID: 18024497
Johnston, J. M., Cook, G. A., Tomich, J. M., and Sansom, M. S. (2006) Conformation And Environment Of Channel Forming Peptides: A Simulation Study. Biophys J. 90:1855-1864.