Department of Biochemistry & Molecular Biophysics
141 Chalmers Hall
Manhattan, KS 66506
785-532-6121
785-532-7278 fax
biochem@k-state.edu



Biotechnology Core Facility
206 Burt Hall
785-532-5956
785-532-6297 fax



Biomolecular NMR Facility
37 Chalmers Hall
785-532-2345

Dolores J. Takemoto, Ph.D., Emeritus Professor

Complete Publications List

2010s | 2000s | 1990s | 1980s | At the University of S. California | At Colorado State University

2010s

Banerjee D, Das S, Molina SA, Madgwick D, Katz MR, Jena S, Bossmann LK, Pal D, Takemoto DJ. Investigation of the reciprocal relationship between the expression of two gap junction connexin proteins, connexin46 and connexin43. J Biol Chem. 2011 Jul 8;286(27):24519-33. Epub 2011 May 23.

Das S, Wang H, Molina SA, Martinez-Wittinghan FJ, Jena S, Bossmann LK, Miller KA, Mathias RT, Takemoto DJ. PKC?, role in lens differentiation and gap junction coupling. Curr Eye Res. 2011 Jul;36(7):620-31. Epub 2011 May 20.

Burr DB, Molina SA, Banerjee D, Low DM, Takemoto DJ. Treatment with connexin 46 siRNA suppresses the growth of human Y79 retinoblastoma cell xenografts in vivo. Exp Eye Res. 2011 Apr;92(4):251-9. Epub 2011 Feb 12.

Davis, L., Ragan, E., Takemoto, D., Tomich, J. (2010) Molecules & Society Laboratory Manual. Kendall Hunt Publishing Co, Dubuque, IA, 124 pp. ISBN 978-1-61549-123-0.

Tomich, J.M. and Takemoto, D. Molecules and Society. (2010) eBook. Kendall Hunt Publishing Co, Dubuque, IA. ISBN 978-1-61549-121-6.

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2000s

Yevseyenkov VV, Das S, Lin D, Willard L, Davidson H, Sitaramayya A, Giblin FJ, Dang L, Takemoto DJ. Loss of protein kinase Cgamma in knockout mice and increased retinal sensitivity to hyperbaric oxygen. Arch Ophthalmol. 2009 Apr;127(4):500-6.

Zhang Y, Snider A, Willard L, Takemoto DJ, Lin D. Loss of Purkinje cells in the PKCgamma H101Y transgenic mouse. Biochem Biophys Res Commun. 2009 Jan 16;378(3):524-8. Epub 2008 Dec 3.

Akoyev V, Das S, Jena S, Grauer L, Takemoto DJ. Hypoxia-regulated activity of PKCepsilon in the lens. Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1271-82. Epub 2008 Nov 7.

Das S, Lin D, Jena S, Shi A, Battina S, Hua DH, Allbaugh R, Takemoto DJ. Protection of retinal cells from ischemia by a novel gap junction inhibitor. Biochem Biophys Res Commun. 2008 Sep 5;373(4):504-8. Epub 2008 Jun 30.

Shi A, Nguyen TA, Battina SK, Rana S, Takemoto DJ, Chiang PK, Hua DH. Synthesis and anti-breast cancer activities of substituted quinolines. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3364-8. Epub 2008 Apr 13.

Lin D, Takemoto DJ. Protection from ataxia-linked apoptosis by gap junction inhibitors. Biochem Biophys Res Commun. 2007 Nov 3;362(4):982-7. Epub 2007 Aug 27.

Barnett ME, Madgwick DK, Takemoto DJ. Protein kinase C as a stress sensor. Cell Signal. 2007 Sep;19(9):1820-9. Epub 2007 Jun 12. Review.

Lin D, Harris R, Stutzman R, Zampighi GA, Davidson H, Takemoto DJ. Protein kinase C-gamma activation in the early streptozotocin diabetic rat lens. Curr Eye Res. 2007 Jun;32(6):523-32.

Lin D, Shanks D, Prakash O, Takemoto DJ. Protein kinase C gamma mutations in the C1B domain cause caspase-3-linked apoptosis in lens epithelial cells through gap junctions. Exp Eye Res. 2007 Jul;85(1):113-22. Epub 2007 Mar 31.

Akoyev V, Takemoto DJ. ZO-1 is required for protein kinase C gamma-driven disassembly of connexin 43. Cell Signal. 2007 May;19(5):958-67. Epub 2006 Nov 25.

Banerjee, D., Das, S., Molina, S., Madgwick, D., Katz, M., Jena, S., Bossmann, L., Pal, D., and Takemoto, D. (2011) Investigation of the Reciprocal Relationship between the Expression of Two Gap Junction Connexin Proteins, Connexin46 and Connexin43. Journal of Biological Chemistry 2011; 286 (27): 24519-24533.

Yevseyenkov, V., Das, S., Lin, D., Willard, L., Davidson, H., Sitaramayya, A., Giblin, F., Dang, L., and Takemoto, D. (2009) Loss of Protein Kinase C? in Knockout Mice and Increased Retinal Sensitivity to Hyperbaric Oxygen. Arch Ophthalmol 2009; 127 (4): 500-506.

Akoyev, V., Das, S., Jena, S., Grauer, L., and Takemoto, D. (2009) Hypoxia-Regulated Activity of PKCe in the Lens. IOVS 2009; 50 (3): 1271-1282.

Zhang, Y., Snider, A., Willard, L., Takemoto, D., and Lin, D. (2008) Loss of Purkinje Cells in the PKC? H101Y Transgenic Mouse. Biochem. Biophys Res. Commun. 378:524-528.

Das, S., Lin, D., Jena, S., Shi, A., Battina, S., Hua, D., Albaugh, R., and Takemoto, D. (2008) Protection of retinal cells from ischemia by a novel gap junction inhibitor. Biochem. Biophys. Res. Commun., 373:504-508.

Shi, A., Nguyen, T., Battina, S., Rana, S., Takemoto, D., Chiang, P., and Hua, D. (2008) Synthesis and anti-breast cancer activities of substitueted quinolines. Biorg. Med. Chem. Lett. 18:3364-3368.

Barnett, M., Lin, D., Akoyev, V., Willard, L., and Takemotot, D. (2008) Protein Kinase C Epsilon activates lens mitochondrial cytochrome C oxidase subunit IV during hypoxia. Exp. Eye res., 86:226-234.

Lauer, J., Shanks, D., Dai, H., Gong, Y., Snider, A., Prakash, O., and Takemoto, D. (2007) NMR structure/function relationships of the C1B domain of PKCγ:Use of SCA14 mutations to identify PKCγ:14-3-3 interactions. Submitted.—Not yet Published

Barnett, M., Madgewick, D., and Takemoto, D. (2007) PKC as a Stress Sensor. Invited review. Cellular Signalling. 19:1820-1829.

Lin, D., and Takemoto, D. (2007) Protection from ataxia-linked apoptosis by gap junction inhibitors. Biochem. Biophys. Res. Comm. 362:982-987.

Lin, D., Zampighi, G., and Takemoto, D. (2007) Protein kinase C gamma activation in the early-Streptozotocin-Diabetic rat lens. Current Eye Res. 32:523-532 .

Lin, D., Shanks, D., Prakash, O., and Takemoto, D. (2007) Protein kinase C gamma mutations in the C1B domain cause caspase-3-linked apoptosis in lens epithelial cells through gap junctions. Exp Eye Res. epub.

Mo, Y., Barnett, M., Raghava, S., Takemoto, D., and Kompella, U. (2007) Human serum albumin nanoparticles for efficient delivery of Cu, Zn superoxide dismutase (SOD1) gene. Mol. Vis. 13:746-757.

Lin, D., Barnett, M., Lobell, S., Madgwick, D., Shanks, D., Willard, L., Zampighi, G., and Takemoto, D. (2006) PKC gamma knockout mouses lenses are more susceptible to oxidative stress damage. J. Exp. Biol. 209:4371-4378.

Lin, D., Barnett, M., Grauer, L., Robben, J., Jewell, A., Takemoto, L., and Takemoto, D. (2005) Expression of superoxide dismutase in whole lens prevents cataract formation. Mol. Vis. 11:853-858.

Zampighi, G., Planells, A., Lin, D., and Takemoto, D. (2005) Regulation of lens cell-to-cell communication by activation of PKC gamma and disassembly of Cx50 channels. Invest. Ophthalmol. Vis. Sci. 46:3247-3255. (cover picture).

Lin, D. and Takemoto, D. (2005) Oxidative activation of protein kinase C gamma through the C1B domain:effects on gap junctions. J. Biol. Chem. 280:13682-13693.

Qu, H., Madl, R., Takemoto, D., Baybutt, R.,and Wang, W. (2005) Lignans are involved in the antitumor activity of wheat bran in colon cancer SW480 cells. Nutrition and Cancer. 135:598-602.

Lin, D., Lobell, S., Jewell, A., and Takemoto, D. (2004) Differential phosphorylation of connexin 46 and connexin 50 by hydrogen peroxide activation of protein kinase C gamma. Mol. Vis. 10:688-695.

Nguyen, T.A., Takemoto, L., and Takemoto, D. (2004) Inhibition of Gap Junction Activity through the Release of the C1B Domain of Protein Kinase C Gamma from 14-3-3. J. Biol. Chem. 279:52714 -52726.

Montelone, B., Dyer, R., and Takemoto, D. (2003) A Mentoring Program for females and minority faculty members in science and engineering: Effectiveness and Status after 9 years. J. Women and Minorities in Science and Engineering. 9:259-271.

Lin, D., Zhou, J., Zelenka, P., and Takemoto, D. (2003) Protein Kinase C Gamma Regulation of Gap Junction Activity Through Caveolin-1-Containing Lipid Rafts. IOVS. 44:5259-5268.

Lin, D., Boyle, D., and Takemoto, D. (2003) IGF-1-induced Phosphorylation of Connexin 43 by PKC Gamma:Regulation of Gap Junctions in Rabbit Lens Epithelial Cells. Invest. Ophthalmol. Vis. Sci. 44:1160-1168.

Wagner, L., Fowler, V., and Takemoto, D.J. (2002) The Interaction and Phosphorylation of Tropomodulin by Protein Kinase C Alpha in N/N 1003A Lens Epithelial Cells. Molecular Vision, 8:394-406.

Akoyev, V., and Takemoto, D. (2006) ZO-1 is required for protein kinase C gamma-driven disassembly of connexin 43. Cellular Signalling. 19(2007): 958-967

Dolores J. Takemoto, Richard Harris, Al Brightman. John McGill, Duy Hua, Harriet Davidson, Brad Fenwick, and Lynn M. Wagner. (2004) Normalization of lens protein kinase Cy in galactosemic dogs by a novel aldose reductase inhibitor." Veterinary Ophthalmology 7, 3, 163-167.

Drankhan, K., Carter, J., Madl, R., Klopfenstein, C., Padula, F., Lu, Y., Warren, T., Schmitz, N., and Takemoto, Dolores J. (2003) Antitumor Activity of Wheats with High Orthophenolic Content. Nutrition and Cancer. 42(2): 188-194.

Nguyen, Thu Annelise, Boyle, Daniel L., Wagner, Lynn M., Shinohara, Toshimichi and Takemoto, Dolores J. (2003) LEDGF activation of PKC γ and gap junction disassembly in lens epithelial cells. Experimental Eye Research. 76:565-572.

Wagner, L., Saleh, S., Boyle, D., and Takemoto, D. (2002) Effect of protein kinase C gamma on gap junction disassembly in lens epithelial cells and retinal cells in culture. Molecular Vision. 8: 59-66.

Saleh, S., Takemoto, L., Zoukhri, D., and Takemoto, D. (2001) PKC gamma phosphorylation of connexin 46 in the lens cortex. Molecular Vision. 7:240-246.

Lewis, S., Karrer, J., Saleh, S., Chen, Y., Tan, Z., Huan, D., McGill,., Pang, Y., Fenwick, B., Brightman, A., and Takemoto, D. (2001). Synthesis and evaluation of novel aldose reductase inhibitors: Effects on lens protein kinase C gamma. Molecular Vision. 7:164-171.

Wagner, L., and Takemoto, D. (2001) PKC alpha and PKC gamma overexpression causes lentoid body formation in the N/N 1003A rabbit lens epithelial cell line. Molecular Vision. 7:138-144.

Wagner, L., and Takemoto, D. (2001) Protein Kinase C alpha and gamma in N/N 1003A rabbit lens epithelial cell differentiation. MolecularVision. 7:57-62.

S. M. Saleh and D. J. Takemoto (2000) Overexpression of Protein Kinase C-y Inhibits Gap Junctional Intercellular Communication in the Lens Epithelial Cells Exp. Eye Res. 71:99-102.

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1990s

Takemoto, D.J. (1999) Cyclic Nucleotide Phosphodiesterases: Structural and Functional Aspects. Introduction to Cellular Signal Transduction 6: 147-173.

Gonzalez-Charneco, Karen, Takemoto, Dolores J. (1998) Localization of protein kinase C in normal and galactosemic bovine lens epithelial cells in culture. Histochem Cell Biol 110:89-94.

Takemoto, D.J. (1998) Decrease in Raf-1 levels in galactosaemic lens epitheial cells are partially reversed by myo-inositol. Acta Diabetologica 35:145-149 (1998).

Takemoto, D.J. (1998) Effect of Trichosanthin an Anti-Leukemia Protein on Normal Mouse Spleen Cells. Anitcancer Research 18:357-362.

Takemoto, D.J. (1997) Anticancer Activities of 2,5,8,9-Substituted 6-Oxo-1,2,3,4,5,6-hexahydrophenanthridines on Multi-Drug-Resistant Phenotype Cells. 1-7.

Udovichenko, Igor P., Cunnick, Jess, Gonzalez, Karen, Yakhnin, Alexander, and Takemoto, Dolores J. (1996) Protein Kinase C in Rod Outer Segments: Effects of Phosphorylation of the Phosphodiesterase Inhibitory Subunit, Biochem. J. 317:291-295.

Gonzalez, Karen, McVey, Scott, Cunnick, Jess, Udovichenko, Igor P., and Takemoto, Dolores J. (1995) Acridine Orange Differential Staining of Total DNA and RNA in Normal and Galactosemic Lens Epithelial Cells in Culture Using Flow Cytometry. Curr. Eye Res. 14:269-273.

Udovichenko, Igor P., Cunnick, Jess, Gonzalez, Karen, and Takemoto, Dolores J. (1994) Functional Effect of Phosphorylation of the Photoreceptor Phosphodiesterase Inhibitory Subunit by Protein Kinase C. J. Biol. Chem., 269:9850-9856.

Udovichenko, Igor P., Cunnick, Jess, Gonzalez, Karen, and Takemoto, Dolores J. (1994) The Visual Transduction and the Phosphoinositide System: A Link. Pergamon. Cellular Signalling 6:601-605.

Cunnick, J., Twamley, C., Udovichenko, I., Gonzalez, K., and Takemoto, D. (1994) Identification of a binding site on retinal transducin ? for them phosphodiesterase inhibory ? subunit. Biochem. J. 297:87-91.

Gonzalez, K., Udovichenko, I., Cunnick, J, and Takemoto, D.J. (1993) Protein Kinase C in Galactosemic and Tolrestat-treated lens epithelial cells. Short Comm. Current Eye Res. 12:373-377.

Takemoto, D.J., Gonzalez, K., Udovichenko, I., and Cunnick, J. (1993) Cyclic GMP-Regulated Cyclic Nucleotide Phosphodiesterases. Mini Review. Cellular Signalling, 5:549-553.

Udovichenko, I.P., Cunnick, J., Gonzales, K., and Takemoto, D.J. (1993) Phosphorylation of bovine rod photoreceptor cyclic GMP phosphodiesterase. Biochem. J. 295:49-55.

Cunnick, Joan and Takemoto, D. (1993) Bitter Melon (Mordica charantia). J. of Naturopathic Medicine, 4:16-21.

Takemoto, D.J., Hurt, D., Oppert, B., and Cunnick, J. (1992) Domain Mapping of the Retinal Cyclic GMP Phosphodiesterase ?-subunit. Biochem. J. 281:637-643.

Cunnick, J. and Takemoto, D.J. (1992) Carriers of the Mouse rd Gene have Reduced Levels of the Beta Subunit of the Retinal Cyclic GMP Phosphodiesterase. Biochem and Biophys. Res. Com., 184:461-466.

Oppert, B. and Takemoto, D.J. (1991) Identification of the ?-Subunit Interaction Sites in the Retinal Cyclic-GMP Phosphodiesterase ?-subunit. Biochem. and Biophys. Res. Comm., 178:474-479.

Oppert, B., Cunnick, J.M., Hurt, D., and Takemoto, D.J. (1991) Identification of the Retinal Cyclic GMP Phosphodiesterase Inhibitory ?-Subunit Interaction Sites on the Catalytic ?-Subunit. J. Biol Chem., 266:16607-16613.

Oppert, B., Gonzalez, K., Hurt, D., Cunnick, J., and Takemoto, D. J. (1991) Retinal Cyclic-GMP Phosphodiesterase Gammma-subunit: Use of Mutant Synthetic Peptides to Define Function. Biochem. and Biophys. Res. Comm., 181:306-309.

Gonzalez, K., Cunnick, J., and Takemoto, D. (1991) Retinal Cyclic-GMP Phosphodiesterase ?-Subunit: Identification of Functional Residues in the Inhibitory Region. Biochem and Biophys. Res. Comm., 181:1094-1096.

Maxwell, S.A., Hurt, D., Brightman, A.H., and Takemoto, D. (1991) Identification and Purification of Equine Retinal S-Antigen, Prog. in Vet. and Comparative Ophthalmology, 1:19-23.

Thirkill, C.E., Roth, A.M., Takemoto, D.J., Tyler, N.K., and Keltner, J.L. (1991) Antibody Indications of Secondary and Superimposed Retinal Hypersensitivity in Retinitis Pigmentosa. Am. J. of Ophthalmology, 112:132-137.

Maxwell, S.A., Hurt, D., Brightman, A.H., and Takemoto, D. (1991) Humoral Responses to RetinalProteins in Horses with Recurrent Uveitis. Progress in Vet & Comparative Ophthalmology, 1:155-161.

Hua, D.H., Miao, S.W., Bravo, A.A., and Takemoto, D.J. (1991) Asymmetric Total Synthesis of (-)-Lupine and (+)-Epilupinine via ?-Sulfinyl Ketimine. Stereocontrolled Reduction of ?-Sulfinyl Enamines. Synthesis, 11:970-974.

Whalen, M., Bitensky, M., and Takemoto, D. J. (1990) The effect of the gamma subunit the cyclic GMP phosphodiesterase of bovine and frog retinal rod outer segments on the kinetic parameters of the enzyme, The Biochemical Journal, 265:655-658.

Takemoto, D. J. and Cunnick, J. (1990) Visual Transduction in Rod Outer Segments. A minireview. Cellular Signalling, 2:99-104.

Cunnick, J., Sakamoto, K., Chapes, S., Fortner, W., and Takemoto, D. J. (1990) Induction of Tumor Cytotoxic Immune Cells Using a Protein from the Bitter Melon (Momordica charantia). Cellular Immunology, 126:278-289.

Cunnick, J., Hurt, D., Oppert, B., Sakamoto, K., and Takemoto, D. J. (1990) Binding of the Gamma-Subunit of Retinal Rod Outer Segment Phosphodiesterase with Both Transducin and the Catalytic Subunits of Phosphodiesterase. The Biochemical Journal, 271:721-727.

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1980s

Morrison, D., Cunnick, J., Oppert, B. and Takemoto, D. J. (1989) Interaction of the ?-Subunit of retinal rod outer segment phosphodiesterase with transducin. J. Biol. Chem. 264:11671-11681.

Cunnick, J., and Takemoto, D. J., (1989) Analyses of proteins from rcdl Irish Setters, in Inherited and Environmentally Induced Retinal Disorders Vol 314:441-454 (Alan R. Liss, Inc.)

Cunnick, J., Rider, M., Takemoto, L. J., and Takemoto, D. J. (1988). Rod/cone dysplasia in Irish Setters: Presence of an altered rhodopsin. Biochemical Journal, 250:335-341.

Chang, C., Davis, L., Rider, M., and Takemoto, D. J. (1988) Characterization of nifH mutations of Klebsiella pneumoniae, J. Bact. 170:4015-4022.

Montgomery, D., Cunnick, J., Coulter, M., Sinai-Zingde, G., Takemoto, D. J., and Hua, D. (1988) Synthesis and In vitro cytotoxic activity of 1-phenyl-3-phenyl-amino-4 (p-toluenesulfinyl)-trans-1,5-hexadiene. Leukemia Research, 12:591-596.

Komori, N., Rider, M., Takemoto, D. J., Shichi, H., and Matsumoto, H. (1988) ADP-Ribosylation of bovine S-antigen by cholera toxin, BBRC, 156:1160-1165.

Takemoto, L. J., Kodama, T., and Takemoto, D. J., (1987) Covalent changes at the N- and C-Terminal regions of gamma crystallin during aging of the normal human lens. Exp. Eye Res., 45:207-214.

Takemoto, L. J., Kodama, T. and Takemoto, D. J., (1987) Antisera to synthetic peptides of MIP26K as probes of changes in opaque versus transparent regions within the same human cataractous lens. Exp. Eye Res., 45:179-183.

Takemoto, L. J., Takemoto, D. J., Brown, G., Takehana, M., Smith, and Horwitz, J. (1987) Cleavage from the N-Terminal region of BBP crystallin during aging of the human lens. Exp. Eye Res., 45:385-392.

Morrison, D., Rider, M. and Takemoto, D. J., (1987) Modulation of retinal transducin and phosphodiesterase activities by synthetic peptides of the phosphodiesterase gamma subunit. FEBS. Letters, 222:266-270.

Takemoto, D. J., Morrison, D., Davis, Lawrence, C., and Takemoto, L. J. (1986) C-Terminal peptides of rhodopsin: determination of the optimum sequence for recognition of retinal transducin. Biochem. J., 235:309-312.

Takemoto, D. J., Cunnick, J., and Takemoto, L. J., (1986) Reduced rhodopsin phosphorylation during retinal dystrophy. Biochem. Biophys. Res. Comm., 135:1022-1028.

McMurray, M., Hansen, J., Haley, B., Takemoto, D. J., and Takemoto, L. J. (1985) Interspecies conservation of retinal GTPase: Peptide mapping and photoaffinity labeling. Biochem. J. 225:227-232.

Hansen, J., Takemoto, D. J., and Takemoto, L. (1985) Monoclonal antiserum to gamma crystallin: Characterization and use as a probe of changes in the aging human lens. Lens Research. 2(3):207-219.

Takemoto, D. J., Takemoto, L. J., Hansen, J., and Morrison, D. (1985) Regulation of retinal transducin by carboxyl-terminal peptides of rhodopsin. Biochem. J., 232:669-672.

Takemoto, D. J., Hansen, J., and Takemoto, L. J. (1985) Altered rhodopsin accessibility in the retinal dystrophic mouse. BBRC 132:804-810.

Takemoto, D. J., Spooner, B. and Takemoto, L. J. (1985) Antisera to synthetic peptides of bovine rhodopsin. Use as site-specific probes of disc membrane changes in retinal dystrophic dogs. Biochem. Biophys. Res. Comm. 132:438-444.

Takemoto, D. J., Hansen, J., Takemoto, L. J., Houslay, M., and Marchmont, R. J. (1984) Peptide mapping of cyclic nucleotide phosphodiesterases, in Ad. Cycl. Nuc. and Protein Phos. Res., Vol. 16:55-63.

Takemoto, L. J., Hansen, J., Farber, D., Souza, D., and Takemoto, D. J., (1984) Cyclic GMP phosphodiesterase from bovine retina. Biochem. J. 217:129-133.

Takemoto, D. J., Jilka, C., Rockenbach, S., and Hughes, J. (1983) Purification and characterization of a cytostatic factor with anti-viral activity from the bitter melon. Preparative Biochemistry 13:371-393.

Jilka, C., Strifler, B., Fortner, G. W., Hays, E. and Takemoto, D. J., (1983) In vivo anti-tumor activity of the bitter melon. Cancer Research 43:5151-5155.

Takemoto, D. J., and Jilka, C (1983) Increased content of calmodulin in human leukemia cells. Leukemia Research 7:97-100.

Takemoto, D. J., Dunford, C., Vaughn, D., Kramer, K., Smith, A., and Powell, R. G., (1982) Guanylate cyclase activity in human leukemic and normal lymphocytes: Enzyme inhibition and cytotoxicity of plant extracts. Enzyme 27:179-188.

Takemoto, D. J., Dunford, C., and McMurray, M. (1982) The cytotoxic and cytostatic effects of the bitter melon on human lymphocytes. Toxicon 20:593-599.

Takemoto, D. J., Hansen, J., Takemoto, L. J., and Houslay, M. (1982) Peptide mapping of multiple forms of cyclic nucleotide phosphodiesterase. J. Biol. Chem. 257:14597-14599.

Takemoto, D. J., Jilka, C., and Kresie, R., (1982) Purification of a cytostatic factor from the bitter melon (Momordica charantia). Preparative Biochemistry 12:355-375.

Takemoto, D. J., Haley, B., Hansen, J., Pinkett, O., and Takemoto, L. J. (1981) GTPase from ROD outer segments; characterization by photo affinity labeling and tryptic peptide mapping. Biochem. Biophys. Res. Comm. 102:341-347.

Takemoto, D. J., Kresie, R., and Vaughn, D. (1980) Partial purification and characterization of a guanylate cyclase inhibitor with cytotoxic properties from the bitter melon (Momordica charantia). Biochem. Biophys. Res. Comm. 94:332-339.

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At the University of Southern California

Appleman, M. M., Ariano, M., Takemoto, D. J., and Whitson, R. (1982) Cyclic Nucleotide Phosphodiesterase. In Handbook of Experimental Pharmacology, (Eds., Kababian, J. W. and Nathanson, J. A.) Vol. 58, pp. 261-300. (Invited review.)

Takemoto, D. J., Kaplan, S., and Appleman, M. M. (1979) Cyclic guanosine 3,5'-monophosphate involvement in the alteration of phosphodiesterase activity in mitogen-stimulated human lymphocytes. Biochem. Biophys. Res. Comm. 90:491-497.

Takemoto, D. J., Lee P., Kaplan, S. A., and Appleman, M. M. (1978) Cyclic AMP phosphodiesterase in human lymphocytes and lymphoblasts. J. Cyclic Nucl. Res. 4:123-132.

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At Colorado State University

Takemoto, D. J., Abel, J. H., Jr., Allen, J. C. (1975) The metabolism of corticosterone in the salt gland of the duck Anas platyrhnchos. Gen. Comp. Endo. 26:226-232.

Allen, J. C., Abel, J. H., Jr., and Takemoto, D. J. (1975) Effect of osmotic stress on serum corticoid and plasma glucose levels in the duck Anas platyrhnchos. Gen. Comp. Endo. 26:209-216.

Allen, J. C., Abel, J. H., Jr., and Takemoto, D. J. (1975) Uptake and binding of labeled corticosterone by the salt gland of the duck Anas platyrhnchos. Gen. Comp. Endo. 26:217-224.

Abel, J. H., Jr., Takemoto, D. J., Hoffman, D. H., McNeill, T., Kozlowski, G., Masken, J., and Sheridan, P. (1975) Corticoid uptake by the paraventricular nucleus in the hypothalamus of the duck Anas platyrhnchos. Cell and Tissue Res. 161:285-291.

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