Brandon Garcia, Ph.D., Research Assistant Professor

Complete Publications List

N.W.M. de Jong, K.X. Ramyar, F.E. Guerra, R. Nijland, C. Fèvre, J.M. Voyich, A.J. McCarthy, Garcia BL, K.P.M. van Kessel, J.A.G. van Strijp, B.V. Geisbrecht, and P.A. Haas. Immune evasion by a Staphylococcal Inhibitor 1 of Myeloperoxidase. Proc Natl Acad Sci. 2017 Aug 29;114(35):9439-9444. doi: 10.1073/pnas.1707032114. Epub 2017 Aug 14.

Ye Z., Needham P.G, Estabrooks S.K., Whitaker S.K., Garcia BL, Misra, S., Brodsky, J.L., Camacho, C.J. Symmetry breaking during homodimeric assembly kinetically activates an E3 ubiquitin ligase. Sci. Rep. 2017 May 11; 7(1):1789.

Garcia BL, Skaff A.D., Chatterjee A., Walker J., Wyckoff G.J., Geisbrecht B.V. Identification of C3b-binding small molecule complement inhibitors using cheminformatics J. Immunol. 2017. May 1; 198(9): 3705-3718.

Garcia BL, Zwarthoff SA, Rooijakkers SH, Geisbrecht BV. Novel Evasion Mechanisms of the Classical Complement Pathway. J Immunol. 2016 Sep 15;197(6):2051-60.

Liang X., Garcia BL, Prabhakarana S., Moran O., Meenan N.A.G., Potts J.R., Humphries M.J., Visai L., Höök M. Allosteric Regulation of Fibronectin/α5β1 Interaction by Fibronectin-Binding MSCRAMMs. PLoS One. 2016 Jul 19;11(7):e0159118.

Garcia BL, Zhi H, Wager B, Höök M, Skare JT. Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex. PLoS Pathog. 2016 Jan;12(1):e1005404. PubMed PMID: 26808924; PubMed Central PMCID: PMC4725857.

Takahashi D, Garcia BL, Kanost MR. Initiating protease with modular domains interacts with β-glucan recognition protein to trigger innate immune response in insects. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13856-61. PubMed PMID: 26504233; PubMed Central PMCID: PMC4653190.

Georgoutsou-Spyridonos M, Ricklin D, Pratsinis H, Perivolioti E, Pirmettis I, Garcia BL, Geisbrecht BV, Foukas PG, Lambris JD, Mastellos DC, Sfyroera G. et al. Attenuation of Staphylococcus aureus-Induced Bacteremia by Human Mini-Antibodies Targeting the Complement Inhibitory Protein Efb. J Immunol. 2015 Oct 15;195(8):3946-58. PubMed PMID: 26342032; NIHMSID: NIHMS716260; PubMed Central PMCID: PMC4592844.

Summers BJ, Garcia BL, Woehl JL, Ramyar KX, Yao X, et al. Identification of peptidic inhibitors of the alternative complement pathway based on Staphylococcus aureus SCIN proteins. Mol Immunol. 2015 Oct;67(2 Pt B):193-205. PubMed PMID: 26052070; NIHMSID: NIHMS693726; PubMed Central PMCID: PMC4565748.

Woehl JL, Stapels DA, Garcia BL, Ramyar KX, Keightley A, et al. The extracellular adherence protein from Staphylococcus aureus inhibits the classical and lectin pathways of complement by blocking formation of the C3 proconvertase. J Immunol. 2014 Dec 15;193(12):6161-71. PubMed PMID: 25381436; NIHMSID: NIHMS636592; PubMed Central PMCID: PMC4258549.

Garcia BL, Summers BJ, Ramyar KX, Tzekou A, Lin Z, et al. A structurally dynamic N-terminal helix is a key functional determinant in staphylococcal complement inhibitor (SCIN) proteins. J Biol Chem. 2013 Jan 25;288(4):2870-81. PubMed PMID: 23233676; PubMed Central PMCID: PMC3554951.

Bannantine JP, Lingle CK, Stabel JR, Ramyar KX, Garcia BL, et al. MAP1272c encodes an NlpC/P60 protein, an antigen detected in cattle with Johne's disease. Clin Vaccine Immunol. 2012 Jul;19(7):1083-92. PubMed PMID: 22593240; PubMed Central PMCID: PMC3393375.

Garcia BL, Summers BJ, Lin Z, Ramyar KX, Ricklin D, et al. Diversity in the C3b [corrected] contact residues and tertiary structures of the staphylococcal complement inhibitor (SCIN) protein family. J Biol Chem. 2012 Jan 2;287(1):628-40. PubMed PMID: 22086928; PubMed Central PMCID: PMC3249117.

Garcia BL, Ramyar KX, Ricklin D, Lambris JD, Geisbrecht BV. Advances in understanding the structure, function, and mechanism of the SCIN and Efb families of Staphylococcal immune evasion proteins. Adv Exp Med Biol. 2012;946:113-33. PubMed PMID: 21948365; NIHMSID: NIHMS343054; PubMed Central PMCID: PMC3422867.

Chen H, Ricklin D, Hammel M, Garcia BL, McWhorter WJ, et al. Allosteric inhibition of complement function by a staphylococcal immune evasion protein. Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17621-6. PubMed PMID: 20876141; PubMed Central PMCID: PMC2955122.

Garcia BL, Ramyar KX, Tzekou A, Ricklin D, McWhorter WJ, et al. Molecular basis for complement recognition and inhibition determined by crystallographic studies of the staphylococcal complement inhibitor (SCIN) bound to C3c and C3b. J Mol Biol. 2010 Sep 10;402(1):17-29. PubMed PMID: 20654625; NIHMSID: NIHMS225018; PubMed Central PMCID: PMC2930029.

Jongerius I, Garcia BL, Geisbrecht BV, van Strijp JA, Rooijakkers SH. Convertase inhibitory properties of Staphylococcal extracellular complement-binding protein. J Biol Chem. 2010 May 14;285(20):14973-9. PubMed PMID: 20304920; PubMed Central PMCID: PMC2865291.

Ricklin D, Tzekou A, Garcia BL, Hammel M, McWhorter WJ, et al. A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family. J Immunol. 2009 Aug 15;183(4):2565-74. PubMed PMID: 19625656; NIHMSID: NIHMS199905; PubMed Central PMCID: PMC2881335.

Garcia BL, Tzekou A, Ramyar KX, McWhorter WJ, Ricklin D, et al. Crystallization of human complement component C3b in the presence of a staphylococcal complement-inhibitor protein (SCIN). Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 May 1;65(Pt 5):482-5. PubMed PMID: 19407382; PubMed Central PMCID: PMC2675590.