Let's Talk Testosterone

Many people are eager for hormonal changes to take place rapidly; however it’s very important to remember that the extent of, and rate at which your changes take place, depend on many factors. These factors include your genetics, the age at which you start taking hormones, and your overall state of health.

Think of the effects of hormone therapy as a second puberty. Just as puberty normally takes several years for the full effects to be seen, so too will these new changes take time to develop fully. Taking higher doses of hormones will not necessarily bring about faster changes, but it could endanger your health. And because everyone is different, your medicines or dosages may vary widely from those of your friends, or from what you may have read in books or online.

There are four areas where you can expect changes to occur as your hormone therapy progresses.

Risks associated with testosterone therapy

If you miss a dose of testosterone or change your dosage, you may experience a small amount of spotting or bleeding. However if your periods have stopped, be sure to report any return of bleeding or spotting to your doctor, who may request an ultrasound to be certain the bleeding isn’t a symptom of an imbalance of the lining of the uterus. Sometimes such an imbalance can lead to a precancerous condition, although this is extremely rare in transgender men. Some men may experience a return of spotting or heavier bleeding after months or even years of testosterone treatment. In most cases this represents changes in the body’s metabolism over time. To be safe, always discuss any new or changes in bleeding patterns with your doctor.

It is unclear if testosterone treatment causes an increased risk of ovarian cancer. Ovarian cancer is difficult to screen for, and most cases of ovarian cancer are discovered after is it too late to be treated. A periodic pelvic examination, where your doctor uses a gloved hand to examine your vagina, uterus and ovaries is recommended to help detect this condition.

Your risk of cervical cancer, or HPV, relates to your past and current sexual practices, but even people who have never had a penis in contact with their vagina may still contract HPV infection. The HPV vaccine, can greatly reduce your risk of cervical cancer, and you may want to discuss this with your provider. Pap smears are used to detect cervical cancer or precancer conditions such as an HPV infection. Your provider will make a recommendation as to how often you should have a pap smear. It is unclear if testosterone therapy plays any role in HPV infections or cervical cancer.

Some experts recommend a full hysterectomy, which would include removal of the uterus, ovaries, and fallopian tubes, 5-10 years after beginning testosterone treatment to minimize the risk of cancer and eliminate the need for screening.

Testosterone treatment does not seem to significantly increase the risk of breast cancer, but there’s not enough research to be certain. However it is still important to receive periodic mammograms or other screening procedures as recommended by your doctor. After breast removal surgery, there is still a small amount of breast tissue left behind. It may be difficult to screen this small amount of tissue for breast cancer, though there are almost no cases of breast cancer in transgender men after chest reconstruction surgery.

As a result of your testosterone treatment, your overall health risk profile will change to that of a man. Your risk of heart disease, diabetes, high blood pressure, and high cholesterol may go up, though these risks may still be less than a non-transgender man’s risks. Since men on average live about five years less than women, you could theoretically be shortening your lifespan, though there is not enough research data to know for sure. Fortunately, since you do not have a prostate, you have no risk of prostate cancer and there is no need to screen for this condition.

Other risks you should know about

Testosterone can make your blood become too thick, otherwise known as high hemoglobin or hematocrit count, which can cause a stroke, heart attack or other conditions. This can be a particular problem if you are taking a dose that is too high for your body’s metabolism. Your cholesterol could potentially increase when taking testosterone. Your doctor will perform periodic tests of your blood count, cholesterol, kidney function,and liver functions, and a diabetes screening test in order to closely monitor your therapy. Though it’s not necessary to routinely check your testosterone level, which is an expensive process, your doctor may choose to check it for a variety of reasons--usually if you are having unpleasant symptoms or ongoing bleeding.

Some of the effects of hormone therapy are reversible if you stop taking them. The degree to which they can be reversed depends on how long you have been taking testosterone. Clitoral growth, facial hair, voice changes and male-pattern baldness are not reversible.
If you have had your ovaries removed, it is important to remain on at least a low dose of hormones post-op until you’re at least 50 and perhaps older to prevent a weakening of the bones, otherwise known as osteoporosis.

Practicalities of hormone therapy

Testosterone comes in several forms. Most transgender men use an injectable form to start. Some chose to begin on a lower dose and increase slowly, while others chose to begin at a standard dose. Both approaches have their pros and cons, you should discuss with your doctor the best option for you.

In addition to injections, there are also transdermal forms of testosterone, including patches, gels, and creams. These forms are often more convenient, but can also be more expensive.

Regardless of the type of testosterone you are taking, it’s important to know that taking more testosterone will not make your changes progress more quickly, but could cause serious health complications. Excess testosterone can be converted to estrogen, which may increase your risks of uterine imbalance or cancer. It can also make you feel anxious or agitated, and cause your cholesterol or blood count to get too high.

In conclusion, please be patient and remember that all of the changes associated with the puberty you are about to experience can take years to develop.

We look forward to helping you with all your health care needs and do not hesitate to utilize all of the resources Lafene has to offer.