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Institutional Animal Care and Use Committee

Guideline #13

Death as an Endpoint

The use of death as an endpoint in animal experiments at KSU is strongly discouraged. Legal, regulatory, and moral guidelines require that animal pain and distress be minimized in any experiment. For these reasons, investigators are encouraged to euthanize animals used in potentially fatal experiments prior to the actual death of the animal � if experimental validity will not be compromised. These objectives assume that investigators can differentiate between animals that are found morbid (i.e. affected with disease and illness), and those that are found moribund (i.e. in the state of dying).

Investigators must justify the use of death as an endpoint. Moreover, investigators must monitor experimental animals closely (including weekends and holidays), and should euthanize animals judged to be moribund � if consistent with the objectives of the study.

In some cases, experimental death may a necessary component of the study. The investigator must receive approval to conduct such studies by providing strong scientific justification to the IACUC. Inconvenience or increased costs alone are not justifiable reasons.

LAST REVIEWED AND ADOPTED BY THE IACUC: July 21, 2011