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Researchers help uncover root cause of childhood deafness in the inner ear

Wednesday, Oct. 11, 2017


MANHATTAN — Bigger is not always better, especially when it comes to structures in the inner ear.

 Enlargement of the vestibular aqueduct, or EVA, has long been associated with hearing loss. A new study finally reveals the root cause of how this structure becomes enlarged, and could lead to new approaches to preventing and treating hearing loss associated with EVA and similar disorders. The discovery is the result of collaborative research between Kansas State University and the National Institute on Deafness and Other Communication Disorders, part of the National Institutes of Health. The institute and the NIH’s National Center for Research Resources, now known as the National Center for Advancing Translational Sciences, funded the study.

The paper, "Molecular architecture underlying fluid absorption by the developing inner ear," was published online Oct. 10 in the journal eLife.

"This study provides the first comprehensive picture of the genes and cells involved in fluid absorption by the developing inner ear," said Andrew J. Griffith, M.D., Ph.D., senior author and chief of the Molecular Biology and Genetics Section in the National Institute on Deafness and Other Communication Disorders' Division of Intramural Research. "We know this process is important because mutations in genes that are critical for this process cause hearing loss associated with EVA."

Around 2 or 3 of every 1,000 children in the U.S. are born with a detectable level of hearing loss in one or both ears. Between 5 and 15 percent of children with sensorineural hearing loss — hearing loss caused by damage to sensory cells inside the cochlea — have EVA.

Techniques developed at Kansas State University enabled the researchers to demonstrate for the first time how fluid is absorbed in the inner ear.

"The purpose of this study was to gain insight into the functional, molecular and cellular architecture of the endolymphatic sac and to identify the components of the physiologic developmental pathway that is disrupted in EVA," said Philine Wangemann, university distinguished professor of anatomy and physiology at Kansas State University and a co-corresponding author. "We showed that the endolymphatic sac absorbs fluid that is dependent on the gene, SLC26A4."

A combination of three major approaches was used to define the mechanism underlying fluid absorption in the endolymphatic sac: 1) a pharmacological approach using drugs to probe for the contribution of specific ion transporters to fluid absorption; 2) a tissue-based approach surveying the transcriptome of the entire endolymphatic sac; and 3) a novel cell-based approach surveying the transcriptome of individual cells isolated from the endolymphatic sac, which became possible through techniques developed at the National Institute on Deafness and Other Communication Disorders.

The current paper in eLife is the sixth in a series of studies published by Griffith and Wangemann and their collaborators. The previous studies defined when and where the SLC26A4 gene is required for normal hearing and development of the inner ear. In 2013, the researchers reported that they partially restored hearing and balance by expressing the SLC26A4 gene. The new study provides a better understanding of the interconnection of these factors.

This study was supported by the NIH’s NIDCD — Z01-DC000060, Z01-DC000059, Z01-DC000086, Z01-DC000088, R01-DC012151 and P20-RR017686.

For more information see the following articles: NIDCD Research on EVA and Hearing Loss, Genetics of Enlarged Vestibular Aqueducts (EVA), Enlarged Vestibular Aqueducts and Childhood Hearing Lossand Quick Statistics About Hearing Loss.


National Institute on Deafness and Other Communication Disorders

Joe Montgomery


Download the following photo.

Inner ear

This diagram shows the anatomy of the inner ear. Hearing loss and deafness may occur when the inner ear is enlarged due to failure of fluid absorption in the endolymphatic sac. This failure of fluid absorption has now been established as a root cause of hearing loss. Source: National Institutes of Health/National Institute on Deafness and Other Communication Disorders.