Biography

2023-Pres.
2022-2023
2019-2022
2018-Pres.
2007-2018
2002-2007
1998-2002
1996-1998
1991-1996
1988-1991
1984-1988

Dean, College of Arts and Sciences
Interim Dean, College of Arts and Sciences
Associate Dean for Research
Professor
Associate Professor
Assistant Professor
Research Scientist, Oak Ridge National Laboratory
Postdoctoral Associate, Oak Ridge National Lab
Ph.D., University of North Carolina at Chapel Hill
B.S., Chemistry, University of West Florida
B.S., Biology, Harvard College

Research Overview

The research interests of our group are focused on developing novel separation and sample handling components for microfluidic (Lab-on-a-Chip; μTAS) devices and then using these devices to solve interesting bioanalytical problems with special emphasis in the areas of protein separations (proteomics) and single cell analysis. This research is multidisciplinary in nature drawing upon knowledge in the fields of chemistry, physics, engineering, cell biology, and biochemistry.

Selected publications

Covarrubias-Zambrano, O.; Motamedi, M.; Ameredes, B.T.; Tian, B.; Calhoun, W.J.; Zhao, Y.; Brasier, A.R.; Kalubowilage, M.; Malalasekara, A.P.; Yapa, A.S.; Wang, H.; Culbertson, C.T.; Troyer, D.L. and Bossmann, S.B. Optical Sensing of Biomarkers on Mucosal Inflammation. Nanomedicine, Nanotechnology, Biology, and Medicine. 2022, 40, 102476. DOI: 10.1016/j.nano.2021.102476.

Sibbitts, J. and Culbertson, C.T. Measuring Stimulation and Inhibition of Intracellular Nitric Oxide Production in SIM-A9 Microglia using Microfluidic Single Cell Analysis Analytical Methods, 2020, 12(38) 4665-4673 DOI:1039/d0ay01578d.

Kalubowilage, M., Covarrubias-Zambrano^, O., Malalasekera, A.P., Wendel, S.O.,Wang, H., Yapa, A.S., Chlebanowski^, L., Toledo^, Y., Ortega^, R., Janik, K.E., Shrestha, T.B., Culbertson, C.T., Kasi, A., Williamson, S., Troyer, D.L.,Bossmann, S.H. Early Detection of Pancreatic Cancers in Liquid Biopsies by Ultrasensitive Fluorescence Nanobiosensors. Nanomedicine, 2018, 14(6), 1823-1832. DOI: 10.1016/j.nano.2018.04.020.

Sibbitts, J.; Sellens, K. A.; Jia, S.; Klasner, S. A., and Culbertson, C.T. Cellular Analysis Using Microfluidics. Anal. Chem., 2018, 90(1), 65-85, DOI: 10.1021/acs.analchem.7b04519

Sadeghi, J.; Patabadige, D.E.W.; Culbertson, A.H.; Latifi, H. and Culbertson, C.T. Out-of-plane integration of a multimode optical fiber for single particle/cell detection at multiple points on a microfluidic device with applications to particle/cell counting, velocimetry, size discrimination and the analysis of single cell lysate injections. Lab Chip 2017, 17, 145-155 DOI: 10.1039/c6lc01161f.

Patabadige, D.E.W.; Sadeghi, J.; Latifi, H.; Culbertson, A.; and Culbertson, C.T. Integration of Optical Fibers with Multilayer Microfluidic Devices for Single Cell Analysis, 2016, Analytical Chemistry, ASAP article. DOI: 10.1021/acs.analchem.6b03133.

Patabadige, D.E.W.; Mickleburgh, T.; Ferris, L.; Brummer, G.; Culbertson, A. and Culbertson, C.T. High Throughput Microfluidic Device for Single Cell Analysis using Multiple Integrated Soft Lithographic Pumps, 2016, Electrophoresis, 37(10) pp. 1337-1344 DOI: 10.1002/elps.201500557

Patabadige, D.E.W.; Jia, S.; Sibbitts, J.; Sadeghi, J.; Sellens, K.; and Culbertson, C.T. Micrototal Analysis Systems: Fundamental Advances and applications. 2016, Analytical Chemistry 88(1), pp. 320-338. DOI: 10.1021/acs.analchem.5b04310

Madiyar, FR; Saheel, B; Swisher, LZ; Culbertson, CT; Huang, X; Li, J. Integration of a nanostructured dielectrophoretic device and a surface-enhanced Raman probe for highly sensitive rapid bacteria detection. 2015. Nanoscale. 7(8), pp. 3726-3736.

Culbertson, CT; Mickleburgh, TG; Stewart-James, SA; Sellens, KA; Pressnall, M. Micro Total Analysis Systems: Fundamental Advances and Biological Applications. Analytical Chemistry, 2014, 86(1), pp 95–118.

Metto, EC; Evans, K; Barney, P; Culbertson, AH; Gunasekara, DB; Caruso, G; Hulvey, MK; Fracassi da Silva, JA; Lunte, SM; Culbertson, CT. An Integrated Microfluidic Device for Monitoring Changes in Nitric Oxide Production in Single T-Lymphocyte (Jurkat) Cells, Analytical Chemistry, 2013, 85(21), 10188-10195.