Stephen K. Chapes, Professor


Director, Johnson Cancer Research Center
Director, Undergraduate Office,
Kansas IDeA Network of Biomedical Research Excellence

Contact information

239C Chalmers Hall
(785) 532-6795


Ph.D., 1981, University of Illinois-Urbana Champaign, Department of Pathobiology.

Area(s) of Specialization



BIOL 670 Immunology
BIOL 671 Immunology Lab
BIOL 840 Molecular and Cellular Immunology
BIOL 850 Advances in Immunology-Inflammatory Cells

Research Focus

Projects in my laboratory focus on macrophages, inflammatory cells and other white blood cells. I am interested in the function of these cells, the role these cells have in infectious diseases and the impact of space flight on these cells.


Kurti, S.P., S.K. Rosenkranz, S.K. Chapes, C.S. Teeman, B.J. Cull, S.Z. Emerson, M. Levitt, J.R. Smith, C.A. Harms. 2017. Does chronic physical activity level modify the airway inflammatory response to an acute bout of exercise in the post-prandial period? Applied Physiology, Nutrition, and Metabolism 42(2):173-180. doi: 10.1139/apnm-2016-0335. (PMID: 28121185; PMCID: PMC5357083)

Rettig*, T.A., C. Ward*, M.J. Pecaut and S.K. Chapes. 2017. Validation of Methods to Assess the Immunoglobulin Gene Repertoire in Tissues Obtained from Mice on the International Space Station. Gravitational and Space Research 5(1):2-23 (*Co-first authors); (Cover Feature:

Dib, L.H., M.T. Ortega, T.L. Melgarejo and S.K. Chapes. 2016. Establishment and characterization of DB-1: A leptin receptor-deficient murine macrophage cell line. Cytotechnology 68(4), 921-933 (PMID:25599862; PMC4960141)

Shi, Z., S.K. Chapes, D. Ben-Arieh, J. Wu. 2016. An agent-based model of a hepatic inflammatory response to Salmonella: A computational study under a large set of experimental data. PLoS One 11(8):e0161131. doi: 10.1371/journal.pone.0161131. (PMID:27556404; PMC4996536)

Dib LH, Ortega MT, Fleming SD, Chapes SK*, Melgarejo TL*. 2014. Bone Marrow Leptin Signaling Mediates Obesity-Associated Adipose Tissue Inflammation in Male Mice. Endocrinology 155:40-46. (PMID:24169547; PMC3868799) *Co-Sr. Investigators. Also see the counterpoint article and rebuttal in Endocrinology, 155:12–14, 2014.

Xie L, Fu Q, Ortega MT, Zhou L, Rasmussen D, O'Keefe J, Zhang KK, Chapes SK. 2014. Overexpression of IL-10 in C2D macrophages promotes a macrophage phenotypic switch in adipose tissue environments. PloS ONE 9(1):e86541.doi: 10.1371/journal.pone.0086541 (PMID 24466141; PMC3897709).

Chapes SK, Ortega MT. 2013. Understanding macrophage differentiation during space flight: The importance of ground-based experiments before space flight. Recent Patents on Space Technology 3:40-47. (PMID:24432200; PMC3890248).

Chapes, SK, Velasquez SE. 2013. Assessment of the impact of the Kansas IDeA Network of Biomedical Research Excellence program on undergraduate participation in research. J Microbiol and Biology Education 14:47-57 (PMID:23858353; PMC3706165).

Chitko-McKown, CG, Chapes SK, Miller LC, Riggs PK, Ortega MT, Green BT, McKown RD. 2013. Development and characterization of two porcine monocyte-derived macrophage cell lines. Results in Immunology 3:26-32 (PMID:23610747; PMC3631004).

Drolia, R, Von Ohlen T, Chapes SK. 2013. Ehrlichia chaffeensis replication sites in adult Drosophila melanogaster . Int J Med Microbiol 303: 40– 49. (PMID:23306065;PMC3558598) Also see the RNAi screening center blog.

View the complete publication list in NCBI