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Export Controls Compliance Program

Pathogens, Toxins, Etc.

 

A

B

C

D

1

Controlled By Regulation:

Select Agent 42CFR72.7

Export Regs15CFR774,

USDA-APHIS 7CFR331.2; 9CFR121.2(a)(b)

2

Human pathogens, zoonoses, & "toxin" (EAR ECN 1C351) All vaccines and " immunotoxins" are excluded from the scope of this entry. See also 1C991

 

 

 

Viruses

 

 

 

Chikungunya virus

no

yes

 

Crimean-Congo haemorrhagic fever virus

yes

yes

 

Dengue fever virus

no

yes

 

Eastern Equine Encephalitis virus

yes

yes

 

Ebola viruses

yes

yes

 

Equine Morbillivirus ( Hendra Virus

yes

yes

 

10 

Japanese encephalitis virus

no

yes

 

11 

Kyasanur Forest virus

no

yes

 

12 

Lassa fever virus

yes

yes

 

13 

Louping ill virus

no

yes

 

14 

Lymphocytic choriomeningitis virus

no

yes

 

15 

Marburg virus

yes

yes

 

16 

Monkey Pox

no

yes

 

17 

Murray Valley encephalitis virus

no

yes

 

18 

Nipah virus

no

yes

 

19 

Omsk haemorrhagic fever virus

no

yes

 

20 

Oropouche virus

no

yes

 

21 

Powassan virus

no

yes

 

22 

Pulmonary and renal syndrome- haemorrhagic fever viruses ( Seoul, Dobrava, Puumala, Sin Nombre)

no

yes

 

23 

Rift Valley fever virus

yes

yes

 

24 

Rocio virus

no

yes

 

25 

South American Haemorrhagic fever viruses- Flexal, Guanarito, Junin, Machupo, Sabia

yes

yes

 

26 

St. Louis encephalitis virus

no

yes

 

27 

Tick-borne encephalitis complex viruses

yes

yes

 

28 

Variola major virus (Smallpox virus)

yes

yes

 

29 

Venezuelan Equine Encephalitis virus

yes

yes

 

30 

Viruses causing hantavirus pulmonary syndrome

yes

yes

 

31 

Western equine encephalitis virus

no

yes

 

32 

White pox

no

yes

 

33 

Yellow fever virus

yes

yes

 

34 

Exemptions: Vaccine strains of viral agents ( Junin Virus strain candid #1, Rift Valley fever virus strain MP-12, Venezuelan Equine encephalitis virus strain TC-83, Yellow fever virus strain 17-D) are exempt.

yes

no

 

35 

Bacteria

 

 

 

36 

Bacillus anthracis

yes

yes

 

37 

Brucella abortus, B. melitensis, B. suis

yes

yes

 

38 

Burkholderia (Pseudomonas) mallei

yes

yes

 

39 

Burkholderia (Pseudomonas) pseudomallei

yes

yes

 

40 

Chlamydia psittaci

no

yes

 

41 

Clostridium botulinum

yes

yes

 

42 

Clostridium perfringens, epsilon toxin producting types (Note: does not control Clostridium perfringens strains other than epsilon toxin producing types)

no

yes

 

43 

Enterohaemorrhagic Escherichia coli, serotype 0157 and other verotoxin producing serotypes (does not control nucleic acid sequences assoc with the pathogenicity of E E coli, serotype 0157 etc, except nucleic acid sequences contain coding for the verotoxin

no

yes

 

44 

Francisella tularensis

yes

yes

 

45 

Salmonella typhi

no

yes

 

46 

Shigella dysenteriae

no

yes

 

47 

Yersinia pestis

yes

yes

 

48 

Exemptions: vaccine strains as described in Title 9 CFR, Part 78.1 are exempt.

yes

See 1C991,vaccines  " immunotoxins"

 

49 

Rickettsiae

 

 

 

50 

Bartonella quintana ( Rochalimea quintana, Rickettsia quintana)

no

yes

 

51 

Coxiella burnetii

yes

yes

 

52 

Rickettsia prowazekii

yes

yes

 

53 

Rickettsia rickettsii

yes

yes

 

54 

Fungi

 

 

 

55 

Coccidioides immitis

yes

no

 

56 

Toxins

 

 

 

57 

Abrin

yes

yes

 

58 

Aflatoxins

yes

yes

 

59 

Botulinum toxins

yes

yes

 

60 

Cholera toxin

no

yes

 

61 

Clostridium perfringens epsilon toxin

yes

yes

 

62 

Conotoxins

yes

yes

 

63 

Diacetoxyscirpenol

yes

no

 

64 

HT-2 toxin

no

yes

 

65 

Microcystin ( Cyanginosin)

no

yes

 

66 

Modeccin toxin

no

yes

 

67 

Ricin

yes

yes

 

68 

Saxitoxin

yes

yes

 

69 

Shigatoxin

yes

yes

 

70 

Staphylococcal enterotoxins

yes

yes

 

71 

Tetrodotoxin

yes

yes

 

72 

T-2 toxin

yes

yes

 

73 

Verotoxin

no

yes

 

74 

Volkensin toxin

no

yes

 

75 

Viscum Album Lectin 1 ( Viscumin)

no

yes

 

76 

Exemptions: Toxins for medical use, inactivated for use as vaccines, or toxin preparations for biomedical research use at an LD50 for vertebrates of more than 100 nanograms per kilogram body weight are exempt.

yes

Vaccines & Immunotoxins, except Cuba, Iran, Libya, NoKorea

 

77 

Recombinant organisms/molecules

 

 

 

78 

Genetically modified microorganisms or genetic elements from organisms on Appendix A, shown to produce or encode for a factor associated with a disease.

yes

 

 

79 

Genetically modified microorganisms or genetic elements that contain nucleic acid sequences coding for any of the toxins listed in this Appendix, or their toxic subunits.

yes

 

 

80 

Other restrictions

yes

 

 

81 

The deliberate transfer of a drug resistance trait to microorganisms listed in this Appendix that are not known to acquire the trait naturally is prohibited by NIH Guidelines for Research Involving Recombinant

yes

 

 

82 

Animal pathogens (EAR ECN 1C352)

 

 

 

83 

Viruses

 

 

 

84 

African Swine fever virus

no

yes

 

85 

Avian influenza virus that are defined in EC Directive 92/40/EC as:

 

 

 

86 

Type A viruses with an IVPI in 6 week old chickens <1.2

no

yes

 

87 

Type A viruses H5 or H& subtype for which nucleotide sequencing has demonstrated multiple basic amino acids at the cleavage site of haemagglutinin

no

yes

 

88 

Bluetongue virus

no

yes

 

89 

Foot and mouth disease virus

no

yes

 

90 

Goat pox virus

no

yes

 

91 

Porcine herpes virus ( Aujeszky's disease)

no

yes

 

92 

Swine fever virus (Hog cholera virus)

no

yes

 

93 

Lyssa virus

no

yes

 

94 

Newcastle disease virus

no

yes

 

95 

Peste des petits ruminates virus

no

yes

 

96 

Porcine enterovirus type 9 (swine vesicular disease virus)

no

yes

 

97 

Rinderpest virus

no

yes

 

98 

Sheep pox virus

no

yes

 

99 

Teschen disease virus

no

yes

 

100 

Vesicular stomatitis virus

no

yes

 

101 

Bacteria

 

 

 

102 

Mycoplasma mycoides

no

yes

 

103 

Genetically-modified "microorganisms"  (All vaccines are excluded from the scope of this entry) (EAR ECN 1C353)

 

 

 

104 

Genetically modified "microorganisms" or genetic elements that contain nucleic acid sequences associated with pathogenicity of organisms controlled by 1C351.a to .c or 1C352 or 1C354

 

yes

 

105 

Genetically modified "microorganisms" or genetic elements that contain nucleic acid sequences coding for any of the " toxins" controlled by 1C351.d or "sub-units of toxins" thereof

 

yes

 

106 

Plant Pathogens (All vaccines are excluded) (EAR ECN 1C354)

 

 

 

107 

Xanthomonas albilineans

no

yes

 

108 

Xanthomonas campestris pv. citri including strains referred to as Xanthomonas campestris pv. citri types A, B, C, D, E or otherwise classified as Xanthomonas citri, Xanthomona campestris pv. aurantifolia or Xanthomonas campestris pv. citrumelo

no

yes

 

109 

Fungi

 

 

 

110 

Colletrotrichum coffeanum var. virulans ( Collectotrichum kahawae)

no

yes

 

111 

Cochliobolus miyabeanus ( Helminthosporium oryzae)

no

yes

 

112 

Microcyclus ulei (syn. Dothidella ulei)

no

yes

 

113 

Puccinia graminis (syn. Puccinia graminis f. sp. Tritici)

no

yes

 

114 

Puccinia striformis (syn. Puccinia glumarum)

no

yes

 

115 

Magnaporthe grisea ( pyricularia grisea/pyricularia oryzae)

no

yes

 

116 

Vaccines containing items controlled by ECCNs 1C351, 1C352, 1C353, and 1C354 and immunotoxins (ECN 1C991) License required to ship to Cuba, Iran, Libya and North Korea.

no

yes