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The Smith Research Laboratory

Smith Research Lab
Kansas State University
Department of Chemistry
King Hall 112
1212 Mid-Campus Drive North
Manhattan, KS 66506

Phone Numbers
Office: 785-532-5109
Lab: 785-532-5118
Fax: 785-532-6666
Email: pesmith[at]ksu.edu

Research Overview

The general focus of the group is the study of the effects of solvent and cosolvents on the structure and dynamics of biomolecules in solution. Our main tool is molecular dynamics simulations which are used to provide atomic level detail concerning the properties of these molecules. In particular, we are attempting to: i) extend the application of computer simulations to more physiologically relevant conditions; ii) characterize the denatured state of proteins as produced by different cosolvents (denaturants); and iii) to understand the interactions between peptides and proteins in solution.