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Division of Biology

Division of Biology
Kansas State University
116 Ackert Hall
Manhattan, KS 66506
785-532-6653 fax

Zhilong Yang, Assistant Professor

Zhilong Yang

Contact information

317 Ackert Hall
(785) 532-3062

Lab website: http://www.k-state.edu/yanglab


Ph.D. 2007, University of Nebraska-Lincoln. Microbiology and Molecular Biology.

Area(s) of Specialization

Molecular virology; Virus-host Interactions; Poxvirus replication; Gene expression; Transcriptomics; Genetic engineering; Virus and host innate immune-related genes.

Research Focus

Our research is focused on viral and host cell gene expression during viral infection, which comprises three levels: analysis of viral and host cell gene expression, elucidation of underlying cellular and viral mechanisms that regulate expression, and uncovering subsequent biological impacts on both the host cell and virus. We mainly work on the following areas:
  1. Selective protein translation during viral infection.
  2. Viral and cellular gene expression dynamics during poxvirus infection.
  3. Pervasive gene expression of poxvirus.

Selected Publications

Cao S, Dhungel P, Yang Z. 2017. Going against the Tide: Selective Cellular Protein Synthesis during Virally Induced Host Shutoff. J Virol 10;91(17). pii: e00071-17.

Dai A, Cao S, Dhungel P, Luan Y, Liu Y, Xie Z, Yang Z. 2017. Ribosome Profiling Reveals Translational Upregulation of Cellular Oxidative Phosphorylation mRNAs during Vaccinia Virus-Induced Host Shutoff. J Virol 14;91(5). pii: e01858-16.

Dhungel P, Cao S, Yang Z. 2017. The 5'-poly(A) leader of poxvirus mRNA confers a translational advantage that can be achieved in cells with impaired cap-dependent translation. PLoS Pathog 13(8):e1006602.

Mendez-Rios JD, Yang Z, Erlandson KJ, Cohen JI, Martens CA, Bruno DP, Porcella SF, Moss B. 2016. Molluscum Contagiosum Virus Transcriptome in Abortively Infected Cultured Cells and a Human Skin Lesion. J Virol 90(9):4469-80.

Yang Z, Moss B. 2015. Decoding poxvirus genome. Oncotarget 6(30):28513-4.

Yang Z, Cao S, Martens CA, Porcella SF, Xie Z, Ma M, Shen M and Moss B. 2015. Deciphering poxvirus gene expression by RNA sequencing and ribosome profiling. J Virol 89(13): 6874-86.

Yang Z, Martens CA, Bruno DP, Porcella SF, Moss B. 2012. Pervasive Initiation and 3' End Formation of Poxvirus Post-Replicative RNAs. J Biol Chem 287 (37): 31050-31060.

Yang Z, Bruno DP, Martens CA, Porcella SF, Moss B.2010.  Simultaneous high-resolution analysis of vaccinia virus and host cell transcriptomes by deep RNA sequencing. Proc Natl Acad Sci USA 107(25):11513-8.

View the complete publication list in NCBI