Chingakham Ranjit Singh, Research Assistant Professor
10 Ackert Hall
Ph.D., 2002, North Eastern Hill University, Shillong, India. Biophysics.
Area(s) of Specialization
Translational regulation of protein synthesis. Structure and function of ribosome-inactivating proteins and their possible applications in biomedicine as cytotoxic drugs. Molecular mechanisms of proteasome assembly and regulation.
Not accepting graduate students
Yuji Chikashige, Mackenzie Thornton, Whitney Pepper, Thomas D. Baird, Madelyn Hilgers, Ariana Cecil, Izumi Asano, Haana Yamada, Cheyenne Brunkow, Carter Moravek, Takeshi Urano, Chingakham Ranjit Singh and Katsura Asano (2020) Gcn2, eIF2 alpha kinase mediates combinatorial translational regulation through nucleotide motifs and uORFs in the mRNA 5' leader regions. Nucleic Acids Research 2020 July doi: 10.1093/nar/gkaa608.
Murakami R, Chingakham Ranjit Singh, Morris J, Tang L, Harmon I, Takasu A, Miyoshi T, Ito K, Asano K, Uchiumi T (2018) The Interaction between the Ribosomal Stalk Proteins and Translation Initiation Factor 5B Promotes Translation Initiation. Mol Cell Biol. 2018 Jul 30; 38(16).
Leiming Tang, Jacob Morris, Ji Wan, Chelsea Moore, Yoshihiko Fujita, Sarah Gillaspie, Eric Aube, Jagpreet Nanda, Abbey Anderson, Christian Cox, Hiroyuki Hiraishi, Leiming Dong, Maud Marques, Maika Jangal, Chingakham Ranjit Singh, Hirohide Saito, Michael Witcher, Ivan Topisirovic, Shu-Bing Qian, Katsura Asano. (2017). Competition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide. Nucleic Acids Research 45(20):11941-11953.
Eiji Obayashi, Rafael E. Luna, Takashi Nagata, Pilar Martin-Marcos, Hiroyuki Hiraishi, Chingakham Ranjit Singh, Jan Peter Erzberger, Fan Zhang, Haribabu Arthanari, Jacob Morris, Riccardo Pellarin, Chelsea Moore, Ian Harmon, Evangelos Papadopoulos, Hisashi Yoshida, Mahmoud L. Nasr, Satoru Unzai, Brytteny Thompson, Eric Aube, Samantha Hustak, Florian Stengel, Eddie Dagraca, Asokan Ananbandam, Philip Gao, Takeshi Urano, Alan G. Hinnebusch, Gerhard Wagner, and Katsura Asano (2017) Molecular landscape of the ribosome pre-initiation complex during mRNA scanning: structural role for eIF3c and its control by eIF5. Cell Report 18: 2651–2663
Caitlin Kozel, Brytteny Thompson, Samantha Hustak, Chelsea Moore, Akio Nakashima, Chingakham Ranjit Singh, Megan Reid, Christian Cox, Evangelos Papadopoulos, Rafael E. Luna, Abbey Anderson, Hideaki Tagami, Hiroyuki Hiraishi, Emily Archer Slone, Ken-ichi Yoshino, Masayo Asano, Sarah Gillaspie, Jerome Nietfeld, Jean-Pierre Perchellet, Stefan Rothenburg, Hisao Masai, Gerhard Wagner, Alexander Beeser, Ushio Kikkawa, Sherry D. Fleming, and Katsura Asano (2016) Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation. Nucleic Acids Research 44(18): 8704–8713.
Jean-Pierre H. Perchellet, Elisabeth M. Perchellet, Chingakham Ranjit Singh, Meghan T. Monnett, Elizabeth Studer and Keith R. Buszek (2014) Mechanisms by Which Synthetic 6,7-Annulated-4-substituted Indole Compounds with Antiproliferative Activity Disrupt Mitosis and Block Cytokinesis in Human HL-60 Tumor Cells.Anticancer Research, International Journal of Cancer Research and Treatment (Special Issue on "New Anticancer Agents"). 2014, 34:4.
Chingakham Ranjit Singh, Scott Lovell, Nurjahan Mehzabeen, Wasimul Q. Chowdhury, Erid S. Geanes, Kevin P. Battaile and Jeroen Roelofs (2014) 1.15 Å resolution crystal structure of the Proteasome Assembly Chaperone Nas2 PDZ Domain. Acta Crystallographica Section F. F70, 418-423.
Naoki Nemoto, Tsuyoshi Udagawa, Wasimul Chowdhury, Makoto Kitabatake, Byung-Sik Shin, Hiroyuki Hiraishi, Suzhi Wang, Chingakham Ranjit Singh, Susan J. Brown, Mutsuhito Ohno, and Katsura Asano (2013) Random mutagenesis of yeast 25S rRNA identify bases critical for 60S subunit structural integrity and function.Translation. Vol-1, Issue 2
Alina De La Mota-Peynado, Stella Y. Lee, Brianne M. Pierce, Prashant Wani, Chingakham Ranjit Singh and Jeroen Roelofs (2013) The proteasome-associated protein Ecm29 inhibits proteasomal ATPase activity and in vivo protein degradation by the proteasome. Journal of Biological Chemistry. First Published on August 30, 2013, doi:10.1074/jbc.M113.491662.View the complete publication list in NCBI