Kalyani Pyaram, Assistant Professor

Kalyani Pyaram

Contact information

336 Ackert Hall

Lab website: https://kalyanipyaram.wixsite.com/k-state


Ph.D. 2012, National Centre for Cell Science, Pune University, India. Biotechnology.

Area(s) of Specialization

T cell metabolism, Innate T cell biology, Innate and adaptive immune responses, cellular immunology

Research Focus

My research focuses on understanding the metabolic mechanisms governing the T cell mediated inflammation and inflammatory diseases. Currently we are looking into the role of Keap1-Nrf2 antioxidant system in T cell development and effector functions. We use a multidisciplinary approach involving immunologic, biochemical and metabolic assays to identify and decipher the role of different signaling pathways, nutrients and other factors in deciding T cell fate after antigen stimulation. Reach out to me to talk more, it is really interesting!

Selected Publications

Pyaram K*, Kumar A, Kim YH, Noel S, Reddy SP, Rabb H and Chang CH*. (2019) Keap1-Nrf2 system plays an essential role for Invariant Natural Killer T cell development and homeostasis. Cell Reports. 2019 Apr 16;27(3), p699-707. (*co-senior authors).

Kumar A, Pyaram K, Yarosz E, Hong H, Lyssiotis CA, Giri S and Chang CH. (2019) Enhanced oxidative phosphorylation by PLZF is essential for survival and function of NKT cells. Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7439-7448.

Pyaram K* and Yadav VN* (2018). Advances in NKT cell Immunotherapy for Glioblastoma. J Cancer Sci Ther. 2018;10(6). pii: 533. doi: 10.4172/1948-5956.1000533 (*co-senior authors).

Pyaram K, Sen JM, Chang CH. (2016) Temporal regulation of Wnt/β-Catenin signaling is important for Invariant NKT Cell development and Terminal Maturation. Mol Immunol. Feb 13;85:47-56.

Shin J, Maekawa T, Abe T, Hajishengallis E, Hosur K, Pyaram K, Mitroulis I, Chavakis T, Hajishengallis G. (2015) DEL-1 restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates. Sci Transl Med. 307(7) pp. 307ra155

Prevot N, Pyaram K, Bischoff E, Sen JM, Powell JD, Chang CH. (2015) Mammalian target of rapamycin complex 2 regulates invariant NKT cell development and function independent of promyelocytic leukemia zinc-finger. J Immunol. 194(1):223-30

Yadav VN, Pyaram K, Ahmad M and Sahu A. (2012) Species selectivity in poxviral complement regulators is dictated by the charge reversal in the central complement control protein modules. J. Immunol. 189(3): 1431-1439

Pyaram K, Kieslich CA, Yadav VN, Morikis D and Sahu A (2010). Influence of electrostatics on the complement regulatory functions of Kaposica, the complement inhibitor of Kaposi’s sarcomaassociated herpesvirus. J. Immunol. 184: 1956-1967.

Pyaram K, Yadav VN, Reza MJ, and Sahu A (2010). Virus-complement interaction: an assiduous struggle for dominance. Future Virology. 5: 709-730

Yadav VN, Pyaram K, Mullick J and Sahu A. (2008). Identification of hot spots in variola virus complement inhibitor (SPICE) for human complement regulation. J. Virol. 82: 3283-3294.

View publication list on PubMed