All research with live pathogen cultures or with infected plant tissues are conducted within the biosafety level 3 biocontainment laboratories at the Biosecurity Research Institute (BRI) at Kansas State University (K-State) and at the USDA ARS laboratories at Fort Detrick, Maryland. All research was conducted under permit from USDA APHIS Plant Protection and Quarantine (Permit #P526P-09-01917). Biosecurity protocols relevant to Magnaporthe oryzae were developed and approved by the K-State Institutional Biosafety Committee and the Biosafety Officer at the BRI. Containment was ensured through a combination of mandated and supervised human behavior, the adoption of demonstrated protocols, and the use of relevant technologies. The research objectives for the wheat blast project cover two areas: genome-enabled diagnostics and the identification of host plant resistance among wheat cultivars commonly grown in the U.S.