Publications (since 2001)

Means, J.C. and R.J. Clem. 2008. Evolution and function of the P35 family of apoptosis inhibitors.  Future Virology 3:383-391.

Clem, R.J.  2008.  Baculovirus apoptosis inhibitors. In Encyclopedia of Virology, Third edition.  B.W.J. Mahy and M.H.V. Van Regenmortel, Eds. Oxford: Elsevier. Vol. 1, pp 231-237.

Bryant, B., Blair, C.D., Olson, K.E., and R.J. Clem.  2008.  Annotation and expression profiling of apoptosis-related genes in the yellow fever mosquito, Aedes aegypti.  Insect Biochem. Molec. Biol.  38:331-345.

Clem, R.J.  2007.  Baculoviruses and apoptosis: A diversity of genes and responses.  Curr. Drug Targets 8:1069-1074.

Means, J.C., Penabaz, T., and R.J. Clem. 2007.  Identification and functional characterization of AMVp33, a novel homolog of the baculovirus caspase inhibitor p35 found in Amsacta moorei entomopoxvirus.  Virology 358:446-457.

Deng, Y., Dong, Y., Thodima, V., Clem, R.J., and A.L. Passarelli.  2006.  Analysis and functional annotation of expressed sequence tags from the fall armyworm Spodoptera frugiperda.  BMC Genomics 7:264.  doi:10.1186/1471-2164-7-264.

Means, J.C., Muro, I., and R.J. Clem.  2006.  Lack of involvement of mitochondrial factors in caspase activation in a Drosophila cell-free system.  Cell Death Differ.  13:1222-1234.

Muro, I., Means, J.C., and R.J. Clem.  2005.  Cleavage of the apoptosis inhibitor DIAP1 by the apical caspase DRONC in both normal and apoptotic Drosophila cells.  J. Biol. Chem. 280:18683-18688.

Wright, C.W., Means, J.C., Penabaz, T., and R.J. Clem. 2005.  The baculovirus anti-apoptotic protein Op-IAP does not inhibit Drosophila caspases or apoptosis in Drosophila S2 cells and instead sensitizes S2 cells to virus-induced apoptosis.  Virology  335:61-71.

Clem, R.J.  2005.  The role of apoptosis in defense against baculovirus infection in insects.  Curr. Top. Microbiol. Immunol. 289:113-130.

Muro, I., Monser, K., and R.J. Clem. 2004. Mechanism of Dronc activation in Drosophila cells.  J. Cell Sci. 117: 5035-5041.

Green, M.C., Miller, K.P., and R.J. Clem. 2004. Ubiquitin protein ligase activity of the anti-apoptotic baculovirus protein Op-IAP3.  Virus Res. 105:89-96.

Clarke, T.E. and R.J. Clem. 2003. Insect defenses against virus infection: The role of apoptosis.  Int. Rev. Immunol. 22:401-424.

Means, J.C., Muro, I., and R.J. Clem.  2003. Silencing of the baculovirus Op-iap3 gene by RNA interference reveals that it is required for prevention of apoptosis during Orgyia pseudotsugata M nucleopolyhedrovirus infection of Ld652Y cells.  J. Virol. 77:4481-4488.

Petrik, D.T., Iseli, A., Montelone, B.A., Van Etten, J.L., and R.J. Clem.  2003.  Improving baculovirus resistance to UV inactivation: Increased virulence resulting from expression of a DNA repair enzyme. J. Invert. Pathol. 82:50-56.

Clarke, T.E. and R.J. Clem.  2003.  In vivo induction of apoptosis correlating with reduced infectivity during baculovirus infection.  J. Virol., 77:2227-2232.

Muro, I., Hay, B.A., and R.J. Clem. 2002. The Drosophila DIAP1 protein promotes cell viability by inhibiting constitutive apical caspase activity.  J. Biol. Chem., 277:49644-49650.

Clarke, T.E. and R.J. Clem. 2002.  Lack of involvement of hemocytes in the establishment and spread of infection in Spodoptera frugiperda larvae infected with the baculovirus AcMNPV by intrahemocoelic injection. J. Gen. Virol. 83:1565-1572.

Yoo, S.J., Huh, J.R., Muro, I., Yu, H., Wang, L., Wang, S.L., Feldman, R.M.R., Clem, R.J., Muller, H.-A.J., and B.A. Hay.  2002.  Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms. Nature Cell Biol. 4:416-424.

Wright, C.W. and R.J. Clem. 2002. Sequence requirements for Hid binding and apoptosis regulation in the baculovirus inhibitor of apoptosis Op-IAP: Hid binds Op-IAP in a manner similar to Smac binding of XIAP. J. Biol. Chem. 277:2454-2462. 

Clem, R. J.  2001.  Baculoviruses and apoptosis: The good, the bad, and the ugly.  Cell Death Differ. 8:137-143.