Novel Peptide-Based Hydrogels

Reference Number: 10-02

Inventors: Xiuzhi Susan Sun and Hongzhou Huang

Description:

Peptide-based biopolymers have become attractive for various biotechnology applications such as drug delivery, tissue engineering scaffolds, and other biotechnology related applications. Researchers at Kansas State University have discovered a peptide that possesses reversible liquid-hydrogel properties based on mechanical shear at room temperature. The peptide contains 19 amino acids with a molecular weight of about 1740 Da.

Advantages:
The main feature of this peptide is that it can form a hydrogel at low concentrations (0.1% or above) with ion (calcium or sodium) as a trigger at a pH ranging from 5.0 – 11. The hydrogel exhibits shear thinning properties, and becomes micro gels with Newtonian flow after shaking, and then regains its viscosity reforming the hydrogel upon decreasing the shear rate. This hydrogel uses water as a solvent and is temperature stable up to 90°C.
Potential advantages also include:
  • No buffer is needed to form the hydrogel in a pH range of 5-11
  • Very rapid recovery of the hydrogel after mechanical shearing
  • The peptide can be prepared using several production techniques
Applications

This hydrogel has several potential applications, including:

  • Scaffolds for tissue engineering
  • Drug delivery
  • Drug and cell encapsulation
Patent Status
  • International Patent Protection (#13/583,528) filed in USA on September 07, 2012.

Kansas State University Research Foundation seeks to have discussions with companies that are interested in licensing and/or research collaborations.

Interested parties should contact:

Kansas State University Institute for Commercialization (KSU-IC)
2005 Research Park Circle Manhattan, KS 66502
Tel: 785-532-3900 Fax: 785-532-3909
E-Mail: ic@k-state.edu