Reference Number: 06-23
Inventors: Duy Hua, Dolores Takemoto, and Peter Chiang
Description:
This technology has a number of compounds containing quinoline moiety that reduce specific gap junction (such as connexins 50) inhibitors for the studies of various neutral effects. The link has been discovered to be that mefloquine and its analogs inhibit gap junctions, which are responsible for neutron transmission. The present invention also contains anti-malarial capabilities that are different from most other agents. Most anti-malarial agents such as mefloquine have serious side effects such as depression and psychotic or suicidal episodes. The present invention does not have these effects.
The specific Cx50 gap junction inhibitor, PQ1, and its analogs can be used to study neural degenerative diseases such as Parkinson’s. There were less psychological effects found in the application of the anti malarial drugs than other alternatives. There is a large market for the anti malarial drugs in military personnel as well as civilian travelers.
Patent Status
Interested parties should contact:
National Institute for Strategic Technology Acquisition and
Commercialization (NISTAC)
2005 Research Park Circle Manhattan, KS 66502
Tel: 785-532-3900 Fax: 785-532-3909
E-Mail: nistac@ksu.edu