Antimicrobial Peptides for Pharmaceutical and Animal Health Applications

Reference Number: 06-11

Inventors: Tonatiuh Melgarejo, Frank Blecha, Yongming Sang, and Maria Ortega

Description:

Antimicrobials are crucial in the treatment of infectious diseases in humans. Many antimicrobials are also used broadly in modern agriculture and aquaculture to treat livestock, fish and plants. The result of such a widespread use of antimicrobials is an increase in the prevalence of resistant pathogens giving rise to therapeutic failures in both humans and animals. Henceforth, new effective antimicrobials need to be developed in order to combat the rising level of microbial adaptation.

Researchers at Kansas State University have created novel synthetic peptides from mammalian origin with very effective antimicrobial activity against Gram-positive and Gram-negative bacteria as well as some intracellular parasites. These novel peptides can be used to kill or prevent further growth of these microorganisms. Additionally, these peptides can potentially be utilized to treat or prevent diseases such as food-borne illness or sexually transmitted diseases, e.g. those caused by members of the generaTrichomonas and/or Neisseria.

Advantages
  • Very low cross-species hemolytic activity
  • Systemic or topical applications
  • Short amino acid sequence leads to a cost effective peptide
Applications
  • Topical treatment for skin infection
  • Topical treatment for venereal disease (e.g. Gonorrhea or Syphilis)
  • Antimicrobial used for packaged food, such as meats
  • Protecting humans and animals against pathogens
  • Preservation of beverages
Patent Status
  • U.S. patent #7,985,832 issued on July 26, 2011
Kansas State University Research Foundation seeks to have discussions with companies that are interested in licensing and/or research collaborations.
Interested parties should contact:

Kansas State University Institute for Commercialization (KSU-IC)
2005 Research Park Circle Manhattan, KS 66502
Tel: 785-532-3900 Fax: 785-532-3909
E-Mail: ic@k-state.edu