K-State Department of Psychology Research:

Behavioral Neuroscience/Animal Learning Behavioral Neuroscience

Dr. Stephen Kiefer's on-going investigations currently involve alcohol research using rodent models (rats and mice). Specifically, the lab is interested in the taste of alcohol as it is believed that taste is an important factor in determining ultimate use (and abuse) of this drug. Given that alcohol is normally only introduced to the body through oral consumption, taste would occupy a pivotal role in decisions about accepting or rejecting this substance. The most current project examines the role of the opiate system in modulating the taste of alcohol. Research has shown conclusively that antagonism of the opiate system via a drug (naltrexone) renders the taste of alcohol solutions more aversive -- rats find the taste to be relatively unpalatable. Additionally, naltrexone decreases alcohol consumption during restricted access tests. A drug that can make alcohol taste bad has the potential as a deterrent for alcohol consumption. Future research plans include an examination of specific brain regions where endogenous opiates produce their effects on alcohol taste and consumption.

Dr. Stephen Kiefer has additional information concerning this research.

Dr. Mary Cain's research interests also include the neurobiological basis of drug abuse using a rodent model. One area of research investigates the neural structures that contribute to elevated drug use caused by genetic or environmental factors. A second research area explores the effects of Pavlovian fear conditioning on drug taking behavior in rats. Methods used in the laboratory include locomotor activity, self-administration, and brain microinfusions. Both research areas are attempting to determine the neuronal structures that contribute to drug taking behavior in order to develop methods to decrease drug use using both behavioral and neurological techniques.

Dr. Mary Cain (785)532-6884 has additional information concerning this research.

Dr. Palmatier's lab studies the reinforcing effects of abused drugs and how they contribute to addiction. Specifically, the lab is interested in nicotine, and how a mild euphoric and intoxicant drug (nicotine) could be responsible for a robust behavior and dependence syndrome (smoking). Given that nicotine is normally self-administered in the context of many other stimuli (taste/smell of smoke, specific peer groups, other drugs such as alcohol) our research has focused on the contribution of non-nicotine stimuli to self-administration of the drug in rats. In doing so, we found that there is a secondary spectrum of effects engendered by nicotine; it has the ability to drastically change the valence of other rewards. In other words, nicotine can make other reinforcing things (peers, taste/smell of smoke, effects of alcohol, etc.) more rewarding or gratifying. The most current project examines this effect of nicotine as a psychometric function of reward valence. That is, in order for nicotine to make something else better, the something else has to be evaluated as 'good' (reinforcing). We are trying to understand two things about the non-nicotine rewards: 1) How good is good enough (to be enhanced by nicotine)? and 2) Is there such a thing as too good? Presumably this secondary effect of nicotine has limits, understanding what those limits are will help us to understand how nicotine changes the 'natural' smoking environment and may help us to develop better behavioral and pharmacological strategies for people who want to quit smoking. For example, future studies will begin to build on a recent finding that one of the best pharmacological smoking cessation aides, bupropion (Zyban (R)), also enhances the valence of other rewards. We will begin to evaluate whether this effect of bupropion is replacing a critical aspect of smoking and whether future cessation aides will be more effective if they have comparable reward-enhancing effects.

Dr. Matthew Palmatier has additional information concerning this research.

Animal Learning and Behavior

Dr. Jerome Frieman's research interests include Pavlovian conditioning, operant conditioning, and social learning in hamsters and rats. Recent research has focused on social learning in dwarf hamsters (Phodopus campbelli) and golden hamsters (Mesocricetus auratus), operant conditioning in dwarf hamsters, kin recognition in dwarf hamsters, and Pavlovian conditioning in rats.

Dr. Jerome Frieman has additional information concerning this research.