Office: BH 412
My research is utilizing a rodent model of autism to examine the neurobiology of the disorder. In addition to examining social interactions, and repetitive behavior, the lab will be examining changes in cognitive flexibility and multisensory processing. We are using the VPA (valproic acid) model of autism because it has both construct and face validity and provides a way to examine behavioral changes developmentally. Projects include looking at differences between control and VPA treated rats in cognitive attention tasks, eyeblink conditioning, and in processing auditory and visual cues. Additionally, we will use neurophysiology and histology to compare differences in brain areas between treated and untreated rats.
The lab is actively recruiting students! Interested undergraduate or graduate students should email Dr. Plakke. Students will have the opportunity to design experiments as well as participate in collecting and analyzing data. A variety of techniques including behavioral handling and training of animals, neurophysiology, stereotaxic surgery and histology can be learned by students. Students can develop a project and present the work at regional or national conferences and can gain valuable experience sharing their research.
Plakke, B., Romanski, L.M. (2016). Neural circuits in auditory and audiovisual memory. Brain Research. 1640 (Pt B), 278-288.
Plakke, B., Hwang, J., Romanski, L.M. (2015). Inactivation of primate prefrontal cortex impairs auditory and audiovisual working memory. The Journal of Neuroscience, 35(26): 9666-9675.
Plakke, B., Romanski, L.M. (2014). Auditory connections and functions of prefrontal cortex. Review Frontiers in Neuroscience.8:199. Ng, C.W., Plakke, B., Poremba, A. (2014). Neural correlates of auditory recognition memory in the primate dorsal temporal pole. Journal of Neurophysiology, 111(3): 455-69.
Plakke, B., Diltz, M.D., Romanski, L.M. (2013). Coding of vocalizations by single neurons in ventrolateral prefrontal cortex. Hearing Research, 305:135-143.
Plakke, B., Ng, C.W., Poremba, A. (2013). Neural correlates of auditory recognition memory in primate lateral prefrontal cortex. Neuroscience, 244: 62-76.
Ng, C.W., Plakke, B., Poremba, A. (2009). Primate auditory recognition memory performance varies with sound type. Hearing Research, 256: 64-74.
Plakke, B., Freeman, J.H., Poremba, A. (2009). Metabolic mapping of the rat forebrain during delay and trace eyeblink conditioning. Neurobiology of Learning and Memory, 92(3): 335-44.
Plakke, B., Ng, C. W., Poremba, A. (2008). Scopolamine impairs auditory delayed matching-to-sample performance in monkeys. Neuroscience Letters, 438(1), 126-130.
Plakke, B., Freeman, J.H., Poremba, A. (2007). Metabolic mapping of the rat cerebellum during delay and trace eyeblink conditioning. Neurobiology of Learning and Memory, 88:11-18.