Office: BH 412
Our laboratory has focused on alcohol using rodent models (rats and mice). Specifically, we have been interested in the taste of alcohol as we believe that taste is an important factor in determining ultimate use (and abuse) of this drug. Given that alcohol is normally only introduced to the body through oral consumption, taste would occupy a pivotal role in decisions about accepting or rejecting this substance. Our recent project examined the role of the opiate system in modulating the taste of alcohol. We have shown conclusively that antagonism of the opiate system via a drug (naltrexone) renders the taste of alcohol solutions more aversive - rats find the taste to be relatively unpalatable. Additionally, naltrexone decreases alcohol consumption during restricted access tests. Obviously, a drug that can make alcohol taste bad has the potential as a deterrent for alcohol consumption.
Higley, A.E., & Kiefer, S.W. (2007). Delta receptor antagonism, ethanol taste reactivity, and ethanol consumption in outbred male rats. Alcohol, 40, 143-150.
Deehan, G.A. Jr., Cain, M.E., & Kiefer, S.W. (2008). Differential rearing conditions alter operant responding for ethanol in outbred rats. Alcoholism: Clinical and Experimental Research, 31, 1692-1698.
Hill, K.G., Sable, H.J.K., Ferraro, F.M. III, & Kiefer, S.W. (2010). Chronic naltrexone treatment and ethanol responsivity in outbred rats. Alcoholism: Clinical and Experimental Research, 34, 272-279.
Higley, A.E, Spiller, K., Grundt, P., Newman, A.H., Kiefer, S.W., Xi, Z.-X., & Gardner, E.L. (2011). PG01037, a novel dopamine D3 receptor antagonist, inhibits the effects of methamphetamine in rats. Journal of Psychopharmacology, 25, 263-273.
Deehan, G.A.., Palmatier, M.I., Cain, M.E., & Kiefer, S.W. (2011). Differential rearing conditions and alcohol preferring rats: Consumption of and operant responding for ethanol. Behavioral Neuroscience, 125, 184-193.
Higley, A.E., Kiefer, S.W., Li, X., Gaal, J., Xi, Z.-X., & Gardner, E.L. (2011). Dopamine D3 receptor antagonist SB-277011A inhibits methamphetamine self-administration and methamphetamine-induced reinstatement of drug-seeking in rats. European Journal of Pharmacology, 659, 187-192.
I have been married to Nancy for over 40 years and we have lived in Tempe, AZ and Los Angeles, CA before moving to Manhattan in 1982. Nancy currently teaches English as a Second Language at the Adult Learning Center in Manhattan. We have two sons: Zachary who graduated cum laude from the Tulane University A.B. Freeman School of Business with majors in Finance and Legal Studies (in addition to a Spanish minor); Brian from the University of Oregon with a degree in Anthropology. Both boys currently live in Denver, CO. The other member of the family is Farfel, a Spaniel mix (Cavalier King Charles Spaniel and Cocker Spaniel: a Cockalier!). If I have free time, I will more than likely spend it fishing.