David Arndt, M.S.

David Arndt

Advisor: Dr. Mary Cain

Description of Research

Generally speaking, my primary research interests involve drugs of abuse and how they affect behavior.  I find it interesting how tiny chemical substances can either beneficially or detrimentally impact people’s lives.  My initial research experience here at Kansas State focused on amphetamine-induced hyperactivity, and how the rewarding effects of amphetamine can be blunted through both glutamatergic alterations and environmental enrichment.  For my master’s thesis I investigated how environmental factors can induce serotonergic alterations that can influence the efficacy of fluoxetine, a commonly prescribed selective serotonin reuptake inhibitor (SSRI).  We are more recently investigating how enrichment-induced glutamatergic alterations can influence rates of amphetamine self-administration.  Lastly, I am currently interested in how environmental factors, such as those elicited by different housing conditions, can alter an epigenetic marker implicated in the rewarding properties of psychostimulants.

Publications:

Arndt, D., Johns, K., Dietz, Z., Cain, M.E. (2015; under revision). Environmental Condition Alters Amphetamine Self-Administration: Role of the MGluR5 Receptor and Schedule of Reinforcement. Psychopharmacology.

Arndt, D., Peterson, C., Cain, M.E.(2015; under revision). Differential Rearing Alters Forced Swim Test Behavior, Fluoxetine Efficacy, and Post-Test Weight Gain in Male Rats. PLOS ONE.

Arndt, D. (2014). The biology of behavior. Psychology in a complex world. Dubuque, IA: Kendall Hunt. ISBN: 978-1-4652-5824-3 [Chapter 2 in General Psychology Textbook].

Arndt, D., Arnold, J., Cain, M.E. (2014).  The Effects of mGluR2/3 Activation on Acute and Repeated Amphetamine-Induced Locomotor Activity in Differentially Reared Male Rats. Experimental and Clinical Psychopharmacology, 22(3): 257-265.

Presentations: *Denotes undergraduate researcher/presenter

Arndt, D., Garcia, E.J., Erickson, G.R., Ulmer, M., Cain, M.E. (2015, Fall). Differential Rearing Alters Amphetamine Self-Administration: Role of mGluR2/3 Activation. Poster presented at the Society for Neuroscience Annual Meeting, Chicago, IL.

Garcia, E.J., Arndt, D., Erickson, G.R., Komer, L.E., Sprick, L.S., Jorgensen, E.T., Parks, K.I., Peterson, C.J., Cain, M.E. (2015, Fall). β-lactam antibiotic affects amphetamine-induced reinstatement in differentially reared rats: Evidence for glutamate homeostasis. Poster presented at the Society for Neuroscience Annual Meeting, Chicago, IL.

Arndt, D., Dietz, Z., Johns, K., Cain, M.E. (2015, Summer). Glutamatergic antagonism and amphetamine self-administration: Role of environmental condition. Poster presented at the NIDA/NIAAA-sponsored poster session held in conjunction with the APA Division 28/50 Social Hour, American Psychological Association Annual Meeting, Toronto, Canada.

Arndt, D., Dietz, Z., Johns, K., Cain, M.E. (2015, Summer). Glutamatergic antagonism and amphetamine self-administration: Role of environmental condition. Poster presented at the “Cutting Edge Research from Emerging Psychological Scientists: Late-Breaking Poster Session.” American Psychological Association Annual Meeting, Toronto, Canada.

Arndt, D., Cain, M.E.(2015, Spring). Rearing environments influence both fluoxetine (Prozac®)efficacy and post-stressor weight gain. Invited talk presented at Southwestern Psychological Association (SWPA) Annual Meeting, Wichita, K.S.

Ulmer, M.*, Arndt, D., Erickson, G., Garcia, E., Cain, M.E. (2015, Spring). Glutamatergic deactivation decreases amphetamine self-administration: role of differential rearing. Poster presented at Southwestern Psychological Association Annual Meeting, Wichita, K.S.

Erickson, G.*, Arndt, D., Ulmer, M., Garcia, E., Cain, M.E. (2015, Spring). Enrichment and glutamate homeostasis: The role of environmental condition on addiction. Poster presented at Southwestern Psychological Association Annual Meeting, Wichita, K.S.

Arndt, D., Dietz, Z., Johns, K., Garcia, E., Cain, M.E. (2014, Fall). The role of differential rearing and mGluR5 inactivation on amphetamine self-administration in male rats. Poster presented at the Society for Neuroscience Annual Meeting, Washington, D.C.

Peterson, C.*, Arndt, D., Turner, R., Cain, M.E. (2014, Fall). Alterations of fluoxetine efficacy in forced swim test behavior between differentially reared male rats. Poster to be presented at the Society for Neuroscience Annual Meeting, Washington, D.C.

Arndt, D.,Dietz, Z, Cain, M.E. (2014, Spring).  The effects of enrichment and social isolation on fluoxetine-induced forced swim test behavior in male rats. Poster presented at the Kansas State Research Forum, Manhattan, KS.

Peterson, C.*, Arndt, D., Cain, M.E. (2014, Spring).  The effects of fluoxetine and environmental enrichment on the expression of depressive-like states in male rats. Poster presented at the Kansas State Research Forum, Manhattan, KS.

Arndt, D., Cain, M.E. (2013, Fall).  The effects of fluoxetine and differential rearing on the expression of depressive-like states in male rats. Poster presented at the Society for Neuroscience Annual Meeting, San Diego, CA.

Arndt, D., Arnold, J., Gregg, P., & Cain, M.E. (2013, Spring). The effects of mGluR2/3 activation on acute and repeated amphetamine-induced hyperactivity in differentially-reared rats. Poster presented at the Nebraska Symposium on Motivation: Motivation to Use Substances, Lincoln, NE.

Arndt, D., & Cain, M.E. (2012, Fall). Attenuation of amphetamine-induced hyperactivity and sensitization through glutamatergic alterations in enriched rats. Poster presented at the Society for Neuroscience Annual Meeting, New Orleans, LA.

*Denotes mentored undergraduate presenter

Teaching Experiences:

Fort Hays State University (primary instructor):

  • Drugs and Behavior (online class) – Fall 2014; Spring 2015; Fall 2015 (x2)
  • Experimental Psychology (online class) – Spring 2015

Kansas State University (primary instructor):

  • General Psychology - Spring 2014

Graduate Teaching Assistant (GTA) assignments (Fall 2011 – Spring 2013):

  • Departmental Experimental Credits Coordinator for Sona Systems
  • Freshman Seminar
  • Junior Seminar
  • Drugs and Behavior
  • Psychobiology
  • Principles of Learning

Education

August 2014               
     


M.S., Psychology (Behavioral Neuroscience)
Kansas State University, Manhattan, KS
Thesis: Environmental Enrichment and Serotonergic Alterations on Depressive-Like States in Rats
Advisor: Mary E. Cain, Ph.D.

May 2010

B.S., Psychology, Magna Cum Laude
University of Kentucky, Lexington, KY


Contact Information

Email: david23@ksu.edu

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