TO THE HERMAN LAB!
are two very different projects ongoing in the Herman laboratory.
The main reseach question of the lab is to link responses of
living systems to environmental change at the genetic level.
The question is, which genes are most important for how
organisms respond to the environment. Our approach is to
implement projects that meld the disciplines of genetics
and ecology in the discipline of Ecological
Genomics. The Herman Lab is part of a multidisciplinary
group that is investigating the genetic
basis for the changes in nematode species composition in response to environmental cues. We use genomic approaches
such as transcriptomics and next generation sequencing techiniques
to discover ecologically important genes and study their
functions. The long-term goal of this project is to discover
which genes are induced or repressed in response to variations
in resource availability. Our current focus is on interactions
of bacteria-feeding nematodes with their biotic environment,
The other has long been a focus of research in our lab and concerns
of cell polarity in developing systems using the
nematode, C. elegans as a model. We are studying cell polarity
in the free-living soil nematode Caenorhabditis elegans because it has a small number of cells, all of which can
be seen in the light microscope, and is amenable to genetic
analysis. The overall goal of this project is to understand
how cell polarity is generated and maintained during animal
development. Our approach is to identify and study genes
involved in the control of cell polarity by identifying
mutations that disrupt the polarities of individual cells.
Much of our work has focused on the role Wnt signaling pathways
play in the control of cell polarity. Our current work aims
to discover how signaling pathways interact with the centrosome
to control cell polarity in developing tissues.
located in the Division
of Biology at Kansas
part of the
in Molecular, Cellular and Developmental Biology (MCDB)
well as the KSU
Ecological Genomics Institute.