Dr. Min Pi

   Dr. Min Pi
  Research Assistant Professor
  Department of Medicine, Nephrology
  Kidney Institute
  KUMC, University of Kansas
  Phone: (913) 588-7607

In Vivo Assessment of CASR Signaling Mechanisms:
The calcium sensing receptor (CASR) plays a central role in controlling systemic calcium homeostasis via regulation of parathyroid hormone (PTH) production and controls a wide variety of processes in other tissues, including epithelia. We are using genetic engineering in mice to alter the expression of signaling molecules thought to be involved in cellular responses to CASR activation. Changes in several parameters, including PTH secretion and parathyroid cell growth, as a result of altering specific genes will be used to test hypotheses of the CASR signaling process.