CONTACT COBRE
Dept of Anatomy and Physiology,
College of Veterinary Medicine,
Kansas State University,
1600 Denison Avenue,
124 Coles Hall,
Manhattan, KS 66506
Ph: 785-532-4535
Fax: 785-532-4557
cobre@vet.k-state.edu

Core Personnel

Administration:

The Administrative Core is headed by the PI, Dr. Daniel C. Marcus, assisted by the Grant Manager, Ginger Biesenthal. This core organizes and supports the formal mentoring meetings, the COBRE Seminar Series, the Literature Review Series and meetings of both the External Advisory Committee and the Internal Advisory Committee. The PI travels regularly to NCRR meetings in Bethesda, MD to confer with NCRR staff, and meets with regional & national IDeA program committees. The Advisory Committees consider applications for funding from investigators at the participating universities and for additional common-use equipment or facilities.

Program Director

Administrative Staff

Confocal Microfluorometry and Microscopy Core Facility:

This Core facility provides instrumentation, expertise, training and mentoring in confocal microfluorometry and microscopy necessary for the advancement of COBRE research projects. The facility supports projects that require microfluorometry of fast Ca2+ signals in cultured and native epithelial tissues, subcellular visualization of molecules including the 3-dimensional reconstruction of labeling, co-localization experiments where maximal resolution and color separation through emission fingerprinting are necessary, and advanced co-localization techniques such as FRET, for which emission scanning is critical. Instrumentation, expertise, training and mentoring will enable COBRE investigators to establish themselves through advancing their research on the role epithelia play in human health and disease.

Director

  Dr. Philine Wangemann
  University Distinguished Professor
  205 Coles Hall
  Phone: (785) 532-4863
  Fax: (785) 532-4557
  e-mail: wange@vet.k-state.edu

Manager

  Joel Sanneman
  Manager of Confocal Facility
  219 Coles Hall
  Phone: (785) 532-4861
  Fax: (785) 532-4557
  e-mail: jsanneman@vet.k-state.edu

Molecular Biology and Biochemistry Facility:

This Core facility provides: the interface, expertise, training and mentoring in gene array analysis necessary for the advancement of COBRE projects on different epithelia; equipment and support for measurement and analysis of RNA quantity & quality; equipment and support for quantitative, real time PCR and equipment and support for DNA sequencing.  All of the COBRE projects benefit from the support provided by the Molecular Biology and Biochemistry facility.  The facility enables COBRE investigators to establish themselves through advancing their research on the role epithelia play in human health and disease.

Directors

Electrophysiology Core Facility:

This Core facility provides the instrumentation, expertise, training and mentoring in epithelial electrophysiology needed to advance COBRE projects.  Making non-invasive current and non-radioactive ion flux measurements is crucial to the success of the projects.  Keeping our goal of advancing the mentored COBRE projects in mind, we have identified the following equipment for this facility: a vibrating current-density probe, self-referencing ion-selective electrodes and a scanning conductance probe.  This instrumentation and the availability of experienced COBRE mentors, provides COBRE investigators with a firm basis to establish themselves through advancing their research on the role epithelia play in human health and disease.

Director

  Dr. Daniel Marcus
  University Distinguished Professor
  126 Coles Hall
  Phone: (785) 532-4832
  Fax: (785) 532-4557
  e-mail: marcus@vet.k-state.edu

Manager

  Don Harbidge
  Manager, Electrophysiology Core Facility
  125 Coles Hall
  Phone: (785) 532-4535
  Fax: (785) 532-4557
e-mail: dharbidg@vet.k-state.edu