My research is in the area of solid state organic
chemistry, which lies at the interface between physical organic
chemistry and materials science. This is a rapidly emerging discipline
that combines the creative power of organic synthesis with physical,
spectroscopic and structural studies of macroscopic crystals. Although
I have broad interests in many areas of chemistry, our current
research program is concerned with two main themes: (1) understanding,
predicting and controlling the three dimensional structures and
shapes of organic crystals, and (2) understanding, predicting and
controlling the response of crystalline solids to perturbative
stresses, including photochemical bond cleavage, high electric
fields, intense laser fields (NLO), and external anisotropic stresses.
Many of the studies involve organic inclusion compounds because
it is a relatively straightforward matter to change the guest identity,
host-guest stoichiometry, relative populations of guests in solid
solutions, or solvent of crystallization while keeping the host
structure more or less constant. Although we are mindful of possible
applications of the systems that we study, our approach is much
more fundamental than applied as we use organic crystals to ask
and answer important questions about molecular recognition and
about collective and long-range interactions in crystals. We are
pursuing these goals by utilizing a variety of chemical and physical
methods, including organic synthesis, crystal engineering and growth,
solid state NMR, single crystal EPR, videomicroscopy, and optical
spectroscopy, as well as several types of diffraction and scattering.
1. B. Toudic, P. Garcia, C. Odin, P. Rabiller, C. Ecolivet, E. Collet, P. Bourges, G. J. McIntyre, M. D. Hollingsworth, T. Breczewski, "Hidden Degrees of Freedom in Aperiodic Materials," Science, 319, 69-71 (Jan. 4 2008)
2. M. D. Hollingsworth, J. A. Swift, B. Kahr, “J. Michael McBride at 65 - An Appreciation,” Cryst. Growth Des., 5, 2022-2035 (2005). (See cover image.)
3. M. D. Hollingsworth, M. L. Peterson, J. R. Rush, M. E. Brown, M. J. Abel, A. A. Black, M. Dudley, B. Raghothamachar, U. Werner-Zwanziger, E. J. Still, J. A. Vanecko, "Memory and Perfection in Ferroelastic Inclusion Compounds," Cryst. Growth Des., 5, 2100-2116 (2005).
4. M. D. Hollingsworth and M. L. Peterson, "Twinning, Epitaxy, and Domain Switching in Ferroelastic Inclusion Compounds," Proceedings of the NASA Microgravity Materials Science Conference 2002, D. Gillies, N. Ramachandran, K. Murphy, D. McCauley, N. Bennett, eds., 283-288, Feb. 2003.
5. M. D. Hollingsworth, "Crystal Engineering: from Structure to Function," Science, 295, 2410-2413 (March 29, 2002). (See cover image.)
6. M. D. Hollingsworth, M. E. Brown,M. Dudley, H. Chung, M. L. Peterson and A. C. Hillier, "Template Effects, Asymmetry and Twinning in Helical Inclusion Compounds," Angew. Chem. Int. Ed. Engl., 41, 965-969 (2002).
7. M. D. Hollingsworth, M. L. Peterson, K. L. Pate, B. Dinkelmeyer and M. E. Brown, "Unanticipated Guest Motion During a Phase Transition in a Ferroelastic Inclusion Compound," J. Am. Chem. Soc. 124, 2094-2095 (2002).
8. M. D. Hollingsworth, U.Werner-Zwanziger, M. E. Brown, J. D. Chaney, J. C. Huffman, K. D. M. Harris and S. P. Smart, "Spring-loading at the Molecular Level: Relaxation of Guest-Induced Strain in Channel Inclusion Compounds," J. Am. Chem. Soc., 121, 9732-9733 (1999).
9. U. Werner-Zwanziger, M. E. Brown, J. D. Chaney, E. J. Still, M. D. Hollingsworth, "Deuterium NMR Studies of Guest Motions in Urea Inclusion Compounds of 1,6-Dibromohexane with Analytical Evaluation of Spectra in the Fast Motion Limit," Appl. Magn. Reson., 17(2-3), 265-281 (1999).
10. P. Girard, A. E. Aliev, F. Guillaume, K. D. M. Harris, M. D. Hollingsworth, A.-J. Dianoux, P. Jonsen, "Dynamic Properties of Dioctanoyl Peroxide Guest Molecules within the Urea Tunnel Structure: Incoherent Quasielastic Neutron Scattering and Solid State 2H NMR Investigations," J. Chem. Phys., 109, 4078-4089 (1998).
11. P. Girard, A. E. Aliev, F. Guillaume, K. D. M. Harris, M. D. Hollingsworth, A.-J. Dianoux, P. Jonsen, "Reorientational Motions of Dioctanoyl Peroxide Guest Molecules within the Urea Tunnel Structure: Assessment of Two-site Jump Models," Physica B (Amsterdam), 234-236, 112-114 (1997).