Maureen Gorman, Ph.D., Research Associate Professor
Complete Publications List
2020s
Gorman, M.J. (2023) Iron homeostasis in insects. Annual Review of Entomology 68: 51-67. doi.org/10.1146/annurev-ento-040622-092836. Epub ahead of print.
Weber, J.J., Brummett, L.M., Coca, M.E., Tabunoki, H., Kanost, M.R., Ragan, E.J., Park, Y., and Gorman, M.J. (2022) Phenotypic analyses, protein localization, and bacteriostatic activity of Drosophila melanogaster transferrin-1. Insect Biochemistry and Molecular Biology 147: 103811. doi: 10.1016/j.ibmb.2022.103811.
Weber, J.J., Kashipathy, M.M., Battaile, K.P., Go, E., Desaire, H., Kanost, M.R., Lovell, S., and Gorman, M.J. (2020) Structural insight into the novel iron-coordination and domain interactions of transferrin-1 from a model insect, Manduca sexta. Protein Science, Nov 16. doi: 10.1002/pro.3999.
Weber, J.J., Kanost M.R., and Gorman, M.J. (2020) Iron binding and release properties of transferrin-1 from Drosophila melanogaster and Manduca sexta: implications for insect iron homeostasis. Insect Biochemistry and Molecular Biology 125: 103438. doi: 10.1016/j.ibmb.2020.103438.
Noh, M.Y., Kim, S.H., Gorman, M.J., Kramer, K.J., Muthukrishnan, S., and Arakane, Y. (2020) Yellow-g and Yellow-g2 proteins are required for egg desiccation resistance and temporal pigmentation in the Asian tiger mosquito, Aedes albopictus. Insect Biochemistry and Molecular Biology 122: 103386.
Najera, D.G, Dittmer, N.T., Weber, J.J., Kanost, M.R., and Gorman, M.J. (2020) Phylogenetic and sequence analyses of insect transferrins suggest that only transferrin 1 has a role in iron homeostasis. Insect Science, Mar 31;. doi: 10.1111/1744-7917.12783.
Tabunoki, H., Dittmer, N.T., Gorman, M.J., and Kanost, M.R. (2019) Development of a new method for collecting hemolymph and measuring phenoloxidase activity in Tribolium castaneum . BMC Research Notes 12:7.
2010s
Brummett, L.M., Kanost, M.R., and Gorman, M.J. (2017) The immune properties of Manduca sexta transferrin. Insect Biochemistry and Molecular Biology 81: 1-9.
Tabunoki, H., Gorman, M.J., Dittmer, N.T., and Kanost, M.R. (2016) Superoxide dismutase 2 knockdown leads to defects in locomotor activity, sensitivity to paraquat, and increased cuticle pigmentation in Tribolium castaneum . Scientific Reports 6:29583. DOI: 10.1038/srep29583
Peng, Z., Dittmer, N.T., Lang, M., Brummett, L.M., Braun, C.L., Davis, L.C., Kanost, M.R., and Gorman, M.J. (2015) "Multicopper oxidase-1 orthologs from diverse insect species have ascorbate oxidase activity" Feb 17;59C:58-71. doi: 10.1016/j.ibmb.2015.02.005.
Peng, Z., Green, P.G., Arakane, Y., Kanost, M.R., and Gorman, M.J. (2014) A multicopper oxidase-related protein is essential for insect viability, longevity and ovary development. PloS ONE 9: e111344.
Lang, M., Braun, C.L., Kanost, M.R., and Gorman, M.J. (2012) Multicopper oxidase-1 is a ferroxidase essential for iron homeostasis in Drosophila melanogaster. Proceedings of the National Academy of Sciences, USA doi: 10.1073/pnas.1208703109.
Lang, M., Kanost, M.R., and Gorman, M.J. (2012) Multicopper oxidase-3 is a laccase associated with the peritrophic matrix of Anopheles gambiae. PLoS One 7: e33985.
Keshar, P., Nguyen, T.D.T., Gorman, M.J. Barrigan, L.M., Peng, Z., Kanost, M.R., Syed, L.U., Li, J., Zhu, K.Y., and Hua, D.H. (2012) Redox Potentials, laccase oxidation, and antilarval activities of substituted phenols. Bioorganic & Medicinal Chemistry 20: 1679-1689.
Gorman, M.J., Sullivan, L.I., Nguyen, T.D.T., Dai, H., Dittmer, N.T., Syed, L.U., Li, J., Hua, D.H., and Kanost, M.R. (2012) Kinetic properties of alternatively spliced isoforms of laccase-2 from Tribolium castaneum and Anopheles gambiae. Insect Biochem. and Mol. Biol. 42,193-202.
Gorman, M.J., and Arakane, Y. (2010) Tyrosine hydroxylase is required for cuticle sclerotization and pigmentation in Tribolium castaneum. Insect Biochemistry and Molecular Biology 40: 267-273.
2000s
Dittmer, N.T., Gorman, M.J., and Kanost, M.R. (2009) Characterization of endogenous and recombinant forms of laccase-2, a multicopper oxidase from the tobacco hornworm, Manduca sexta. Insect Biochemistry and Molecular Biology 39: 596-606.
Gorman MJ, Dittmer NT, Marshall JL, and Kanost MR (2008) Characterization of the multicopper oxidase gene family in Anopheles gambiae . Insect Biochem. Molec. Biol. 38, 817-824.
Kanost, M.R., and Gorman, M.J. (2008) Phenoloxidases in insect immunity. In Insect Immunology (N. Beckage, ed), Academic Press/Elsevier, San Diego, pp. 69-96.
Gorman, M.J., An, C., and Kanost, M.R. (2007) Characterization of tyrosine hydroxylase from Manduca sexta. Insect Biochemistry and Molecular Biology 37: 1327-1337.
Gorman, M.J., Wang, Y., Jiang, H., and Kanost, M.R. (2007) Manduca sexta hemolymph proteinase 21 activates prophenoloxidase activating proteinase 3 in an insect innate immune response proteinase cascade. Journal of Biological Chemistry 282: 11742-11749.
Gorman, M.J., P. Kankanala, and Kanost, M.R. (2004) Bacterial challenge stimulates innate immune responses in extra-embryonic tissues of tobacco hornworm eggs. Insect Molecular Biology 13:19-24.
Dittmer, N.T., R.J. Suderman, H. Jiang, Y.C. Zhu, M.J. Gorman, K.J. Kramer, and Kanost, M.R. (2004) Characterization of cDNAs encoding putative laccase-like multicopper oxidases and developmental expression in the tobacco hornworm, Manduca sexta, and the malaria mosquito, Anopheles gambiae. Insect Biochemistry and Molecular Biology 34: 29-41.
Zhu, Y., Y. Wang, M.J. Gorman, H. Jiang, and Kanost, M.R. (2003) Manduca sexta serpin-3 regulates prophenoloxidase activation in response to infection by inhibiting prophenoloxidase-activating proteinases. Journal of Biological Chemistry 278: 46556-46564.
Gorman, M.J., and Paskewitz, S.M. (2001) Serine proteases as mediators of mosquito immune responses. Insect Biochemistry and Molecular Biology 31: 257-262.
Gorman, M.J., O.V. Andreeva, and S.M. Paskewitz (2000) Sp22D: a multidomain serine protease with a putative role in insect immunity. Gene 251: 9-17.
Gorman, M.J., and Paskewitz, S.M. (2000) Persistence of infection in mosquitoes injected with bacteria. Journal of Invertebrate Pathology 75: 296-297.
Gorman, M.J., O.V. Andreeva, and Paskewitz, S.M. (2000) Molecular characterization of five serine protease genes cloned from Anopheles gambiae hemolymph. Insect Biochemistry and Molecular Biology 30: 35-46.
1990s
Paskewitz, S.M., S. Reese-Stardy, and Gorman, M.J. (1999) An easter-like serine protease from Anopheles gambiae exhibits changes in transcript abundance following immune challenge. Insect Molecular Biology 8: 329-337.
Paskewitz, S.M., and Gorman, M.J. (1999) Mosquito immunity and malaria parasites. American Entomologist 45: 80-94.
Gorman, M.J., A.M. Schwartz, and Paskewitz, S.M. (1998) The role of surface characteristics in eliciting humoral encapsulation of foreign bodies in Plasmodium-refractory and -susceptible strains of Anopheles gambiae. Journal of Insect Physiology 44: 947-954.
Han, Y.S., C.E. Salazar, S.R. Reese-Stardy, A.J. Cornel, M.J. Gorman, F.H. Collins, and Paskewitz, S.M. (1997) Cloning and characterization of a serine protease from the human malaria vector, Anopheles gambiae. Insect Molecular Biology 6: 385-395.
Gorman, M.J., D.W. Severson, A.J. Cornel, F.H. Collins, and Paskewitz, S.M. (1997) Mapping a quantitative trait locus involved in melanotic encapsulation of foreign bodies in the malaria vector, Anopheles gambiae. Genetics 146: 965-971.
Gorman, M.J., and Paskewitz, S.M. (1997) A genetic study of a melanization response in Plasmodium-refractory and -susceptible strains of Anopheles gambiae. American Journal of Tropical Medicine and Hygiene 56: 446-451.
Gorman, M.J., A.J. Cornel, F.H. Collins, and Paskewitz, S.M. (1996) A shared genetic mechanism for melanotic encapsulation of CM-Sephadex beads and a malaria parasite, Plasmodium cynomolgi B, in the mosquito, Anopheles gambiae. Experimental Parasitology 84: 380-386.
Gorman, M.J., and Kaufman, T.C. (1995) Genetic analysis of embryonic cis-acting elements of the Drosophila homeotic gene Sex combs reduced. Genetics 140: 557-572.
Flory, N., M. Gorman, P.M. Coutino, C. Ford, and Reilly, P.J. (1994) Thermosensitive mutants of Aspergillus awamori glucoamylase by random mutagenesis: inactivation kinetics and structural interpretation. Protein Engineering 7: 1005-1012.
Gorman, M., and Girton, J. (1992) Genetic analysis of deltex and its interaction with the Notch locus in Drosophila melanogaster. Genetics 131:99-112.