Graduate Biochemistry Group faculty
Yeast genetics and biochemistry; research interest in mechanism and control of eukaryotic translation initiation.
Computer modeling of biomolecules.
Plant biochemistry and molecular biology; plant-based bioremediation; nitrogen fixation; science education.
Biochemistry of triacylglycerol biosynthesis; structure and function of membrane bound acyltransferases; genetically modifying the physical properties of seed oils for industrial and biofuel applications.
Regulation of sodium and chloride transport by epithelial cells, with a focus on the functional interactions between the epithelial sodium channel (ENaC) and the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).
Evaluation of surface antigen genes of Ehrlichia chaffeensis and Ehrlichia canis and host immune response against the pathogens using experimental animal model systems.
Innate Immunity; Molecular Basis of Infectious Diseases and Host-Pathogen Interactions; Structural Biology and Molecular Recognition
Mechanisms that underly muscle structure and function.
Pathogenic microbiology and bacterial genetics.
Understanding, treating, and preventing diarrheal disease caused by bacterial pathogens.
Insect biochemistry and molecular biology; structure and function of hemolymph serine proteinases, proteinase inhibitors, and antibacterial response proteins from insects; biochemistry of insect cuticle sclerotization.
Iron acquisition by active transport through the cell envelopes of bacteria; Immunological approaches to bacterial pathogenesis; Biophysical analyses of bacterial membrane transport in living cells.
Structural biology; NMR studies of protein structure, dynamics, and stability in relation to function; serine proteinases and their protein inhibitors; signal transduction enzymes (plant phospholipase D domains).
Intracellular protein trafficking in health and diseases; protein defects in lysosomal storage diseases.
Regulation of mosquito innate immunity; malaria parasite-mosquito interactions.
Characterization of enzymes and genes involved in chitin metabolism and targeting them for insect control; enhancing disease and insect resistance of plants by genetic engineering.
Specific isoforms of Protein Kinase C (PKC) that are regulated connexins during cancer formation.
Structural characterization and molecular recognition using Nuclear Magnetic Resonance (NMR) and Computer Aided Molecular Design (CAMD).
Molecular genetics of aphid salivary glands; hydrolases, proteases and protease inhibitors.
Regulation of protein degradation by the proteasome.
Theoretical Biological Physics; Protein phase behavior; Protein crystallization; Amyloid fibril formation; Drug formulations; Self-assembly.
Plant molecular biology, developmental biology, plant sterols, START domains, sterols and cellulose; broadly focusing on deciphering the molecular mechanisms underlying growth and development of flowering plants.
Understanding physiological regulation of epithelial ion transport.
Computer simulation of the structure and dynamics of peptides, proteins and nucleic acids; cosolvent effects on peptides and proteins; modeling of opioid peptides and their receptors.
Design and characterize atom of synthetic peptides for potential uses as drugs or renewable biomaterials. The lab employs a number of biologic, synthetic, analytic and physical methods to make these characterizations.
Beta-adrenergic receptors, CGRP-receptors, endothelin receptors, Rho-kinase, KCNQ1-KCNE1 potassium channels, pendrin chloride/bicarbonate transporters, pharmacology, confocal microscopy and microfluorometry, immuno-FRET, micro-Ussing chamber and video-microscopy.
Developing and implementing mass-spectrometry-based lipid profiling strategies to understand the roles of particular lipids, as well as genes and proteins involved in lipid metabolism and lipid signaling.
Quality determination; Instrumental analysis; Infrared micro spectroscopy; Chemical imaging; Instrument design and analytical method development in chromatography.
Cell adhesion molecules and their role in cell growth and differentiation.
Protein structure and function; protein folding, misfolding, and aggregation; AAA+ ATPases; molecular chaperones.