Department of Biochemistry & Molecular Biophysics
141 Chalmers Hall
Manhattan, KS 66506
785-532-6121
785-532-7278 fax
biochem@k-state.edu



Biotechnology Core Facility
206 Burt Hall
785-532-5956
785-532-6297 fax



Biomolecular NMR Facility
37 Chalmers Hall
785-532-2345

Courses

Course schedules

Summer 2014 | Fall 2014 | Spring 2014

Course descriptions

Course number
Course name/description
Credits
Semesters offered
Prerequisites
BIOCH 110
Biochemistry and Society

Biochemically oriented topics and news items related to environmental and medical aspects of daily living. Covers selected basic biochemical concepts with applications to humans: proteins as enzymes, energy from foods, biochemical communications and drug interactions, genes and heredity. Intended for nonscience majors.

3I, II, S 
BIOCH 111
Biochemistry and Society Laboratory

Experiments to promote understanding of chemicals and reactions in living systems. Three hours lab a week. Intended for nonscience majors.

1I, II, SBIOCH 110 or concurrent enrollment
BIOCH 265
Introductory Organic and Biochemistry

For students in human ecology, nursing, and other areas desiring an integrated organic and biochemistry course to provide an understanding of carbohydrates, proteins, lipids, and digestive metabolic systems. Three hours lecture and six hours lab a week.

5I, II, SCHM 110
BIOCH 290
Biochemistry Seminar

Lectures and discussions on basic topics in biochemistry.

2II BIOCH 100
BIOCH 399
Honors Seminar in Biochemistry

Lecture, guided reading, and discussion of topics of general interest in biochemistry. Topics will vary depending on the interests and backgrounds of students enrolled.

3IIFreshman Honors Seminar
BIOCH 499
Senior Honors Thesis

Open only to seniors in the arts and sciences honors program. May be used by honors students to satisfy B.S. requirement for BIOCH 799.

2I, II, S BIOCH 755 or concurrent enrollment
BIOCH 521
General Biochemistry

A basic study of the chemistry and metabolism of carbohydrates, lipids, proteins, and nucleic acids.

3I, II, SCHM 350 or 531
BIOCH 522
General Biochemistry Laboratory

A one-semester laboratory course with experiments relating to carbohydrates, lipids, proteins, nucleic acids, and enzymes. Six hours lab a week.

2I, II, SCHM 351 and BIOCH 521 or concurrent enrollment
BIOCH 571
Medical Biochemistry

Covers medically related concepts, structures, pathways and mechanisms in biochemistry. Addresses the fundamental biochemistry behind veterinary, medical, or dental topics and issues. Instructs in the fundamental principles of protein structure and function, enzymology, carbohydrate and lipid metabolism, hormones, biochemical energetics, membranes, nucleic acid and protein metabolism, information transfer and the genetic code, genomic and proteomic analyses, the interdependence of biochemical pathways, pathogenesis, and additional new topics.

3IMATH 220, PHYS 114, CHM 350/351, BIOCH 521
BIOCH 599
Research Training in Biochemistry

Provides laboratory experience for majors and nonmajors in research techniques contributing to ongoing biochemical research. May be repeated up to 8 hours.

1 to 3I, II, SBackground adequate for relevent techniques
BIOCH 755
Biochemistry I

An introduction to physical methods, kinetics, and thermodynamics of biochemical reactions and bioenergetics, chemistry of proteins and amino acids, carbohydrate chemistry, and metabolism. BIOCH 755 and 765 are for students interested in a two-semester comprehensive coverage of biochemistry. For a one-semester course, enroll in BIOCH 521.

3IChemical Analysis, one year of organic chemistry, differential and integral calculus
BIOCH 756
Biochemistry I Laboratory

An intensive laboratory course to accompany BIOCH 755. BIOCH 756 and 766 are sequential courses for students interested in a two-semester comprehensive coverage of biochemistry. For a one-semester laboratory course, enroll in BIOCH 522. Six hours lab a week.

2IBIOCH 755 or concurrent enrollment
BIOCH 757
NMR Laboratory

Basic methods and strategies of nuclear magnetic resonance used in the study of biological molecules. Principles and applications of simple one-dimensional and two-dimensional NMR experiements. Two three-hour laboratories per week. Meets second half of the semester.

1IIBIOCH 755
BIOCH 758
Protein Structure Laboratory

Principles and uses of computational and experimental approaches for studying peptide and protein structure and dynamics: computer modeling and simulation techniques, fluorescence and circular dichroism spectroscopes, microcalorimetry, and analytical ultracentrifugation. Two three-hour laboratories per week. Meets first half of semester.

1IIBIOCH 755
BIOCH 765
Biochemistry II

Continuation of BIOCH 755; lipid chemistry and metabolism, amino acid metabolism, nutrition, nucleic acid chemistry and metabolism, integration of biochemical pathways and metabolic control mechanisms.

3IIBIOCH 755
BIOCH 766
Recombinant DNA Laboratory I

Biochemical manipulation of nucleic acids. Isolation and restriction enzyme characterization of plasmid DNA, ligation of DNA fragments to vector DNA, polymerase chain reaction, Souther blot analysis, DNA sequencing and analysis. Two three-hour labs per week. Meets first half of semester.

1IIBIOCH 522
BIOCH 767
Recombinant DNA Laboratory II

Approaches to study of RNA and proteins using recombinant DNA techniques. RNA extraction and affinity isolation of mRNA, Northern blot analysis, cDNA library construction and screening, bacterial or eukaryotic expression systems, purification and characterization of recombinant proteins, site-directed mutagenesis. Two three-hour labs per week. Meets second half of semester.

1IIBIOCH 522
BIOCH 775
Molecular Biophysics

Survey if the biophysical methods most frequently encountered in biochemistry and related disciplines. It summarized concepts and techniques of physical science used in studying the structure and function of biomacromocules such as proteins and DNA. Applications include classical equilibrium thermodynamics and analytical methods like mass spectrometry and circular dichroism (CD), fluorescence, EPR and nuclear magnetic resonance (NMR) spectroscopy. The class emphasizes the underlying principles and techniques used in determining the molecular weight and shape of biopolymers, biochemical mechanisms of action, and observation of conformational changes in macromolecules.

3IICHM 350/351, MATH 221, PHYS 114, BIOCH 755,756,765
BIOCH 790
Physical Biochemistry

A survey of biophysical methods most frequently encountered in biochemistry and related disciplines. Emphasizes principles underlying methods used in determining the molecular weight and shape of biopolymers and techniques used in detecting conformational changes in nucleic acids, proteins, and polysaccharides.

3IMATH 221, CHM 500 and BIOCH 765
BIOCH 799
Problems in Biochemistry

Problems may include laboratory and/or library work in various phases of biochemistry, agricultural chemistry, or nutrition.

VariesI, II, SBackground adequate for problems undertaken
BIOCH 806
Biochemistry Seminar

Seminar for graduate students in biochemistry.

0 to 1I, II 
BIOCH 815
Nuclear Magnetic Resonance (NMR) Spectroscopy of Macromolecules

A lecture and laboratory course on 'state-of-the-art' multi-dimensional nuclear magnetic resonance methods and strategies in solving three dimensional structure of peptides, proteins, nucleic acids and other macromolecules.

2  
BIOCH 890
Advanced Topics in Biochemistry

Course to present timely topics in Biochemistry.

1 to 3I, II, SConsent of instructor
BIOCH 899
Research in Biochemistry I

Research in biochemistry which may be used for preparation of the M.S. thesis.

VariesI, II, SSufficient training for research undertaken
BIOCH 907
Advanced Topics in Insect Biochemistry

Lectures, readings, and discussion of topics of current interest in insect biochemistry. Topics will include biochemical molecules and processes specific to insects, such as biochemistry of the exoskeleton and regulation of metamorphosis, as well as comparison of insect and mammalian biochemistry.

3II even yearsBIOCH 521
BIOCH 910
Lipids

Chemistry of plant and animal lipids, their occurrence, metabolism, and industrial uses.

2I odd yearsBIOCH 765
BIOCH 915
Biomolecular Modeling

Lectures on the basic principles and skills involved in computer modeling of biomolecules. Students will carry out projects that focus on practical aspects of utilizing publically available simulations and analysis tools to address questions in biochemical and biophysical research.

2I even years 
BIOCH 920
Nucleic Acids

Structure and function of nucleic acids: structures and properties of DNA, RNA, and chromatin; recombinant DNA techniques; mutagenesis and carcinogenesis; protein-nucleic acid interactions; structural influences on replication, transcription, translation, and regulation.

2II even yearsBIOCH 765
BIOCH 930
Proteins

In odd years. Lectures and readings on the chemical nature of proteins; fractionation; purification, structure, chemical and physical properties of proteins and amino acids.

2II odd yearsBIOCH 755 and 765
BIOCH 935
Biochemistry of Cell Regulation

Integration of biochemical pathways and molecular mechanisms regulating cell growth, movement, differentiation, and death. Emphasis on molecular interactions and signaling cascades controlling gene expression, protein synthesis and folding, proteolysis, cytoskeletion, cell cycle, cell survival, and apoptosis.

3II odd yearsBIOCH 765
BIOCH 950
Advanced Topics in Protein Science

In even years. Recent advances in protein biochemistry, including protein structure determination, dynamics, folding, stability, enzyme mechanism and regulation.

3I even yearsBIOCH 765 and 790
BIOCH 997
Postdoctoral Research in Biochemistry

Advanced level research in collaboration with a faculty member, involving projects in any area of biochemistry. Post-graduate training in first three years beyond doctorate.

1 to 12I, II, SPh.D. or equivalent
BIOCH 999
Research in Biochemistry II

Research in biochemistry which may be used for preparation of the Ph.D. thesis.

VariesI, II, SSufficient training for research undertaken