Discussion of biochemistry as a discipline in the life sciences.
Biochemistry and Society
Biochemically oriented topics and news items related to environmental and medical aspects of daily living. Covers selected basic biochemical concepts with applications to humans: proteins as enzymes, energy from foods, biochemical communications and drug interactions, genes and heredity. Intended for nonscience majors.
|3||I and II|
Biochemistry and Society Laboratory
Experiments to promote understanding of chemicals and reactions in living systems. Three hours lab a week. Intended for nonscience majors.
|1||I and S||BIOCH 110 or concurrent enrollment|
Introductory Organic and Biochemistry
For students in human ecology, nursing, and other areas desiring an integrated organic and biochemistry course to provide an understanding of carbohydrates, proteins, lipids, and digestive metabolic systems. Three hours lecture and six hours lab a week.
|5||I and II||CHM 110|
Lectures and discussions on basic topics in biochemistry.
Sophomore Honors Seminar in Biochemistry
Lecture, guided reading, and discussion of topics of general interest in biochemistry. Topics will vary depending on the interests and backgrounds of students enrolled.
|3||II||Freshman Honors Seminar|
Senior Honors Thesis
Open only to seniors in the arts and sciences honors program. May be used by honors students to satisfy B.S. requirement for BIOCH 799.
|2||I, II and S||BIOCH 755 or concurrent enrollment|
A basic study of the chemistry and metabolism of carbohydrates, lipids, proteins, and nucleic acids.
|3||I, II and S||CHM 350|
General Biochemistry Laboratory
A one-semester laboratory course with experiments relating to carbohydrates, lipids, proteins, nucleic acids, and enzymes. Six hours lab a week.
|2||I, II and S||CHM 351 and BIOCH 521 or concurrent enrollment|
Covers medically related concepts, structures, pathways and mechanisms in biochemistry. Addresses the fundamental biochemistry behind veterinary, medical, or dental topics and issues. Instructs in the fundamental principles of protein structure and function, enzymology, carbohydrate and lipid metabolism, hormones, biochemical energetics, membranes, nucleic acid and protein metabolism, information transfer and the genetic code, genomic and proteomic analyses, the interdependence of biochemical pathways, pathogenesis, and additional new topics.
|3||I||MATH 221, PHYS 114, CHM 350/351, BIOCH 521|
Physical Studies of Biomacromolecules
An overview of concepts and techniques of physical science used in studying the structure and function of biomacromolecules such as proteins and DNA. Applications include classical equilibrium thermodynamics and spectroscopic methods including mass spectrometry, circular dichroism (CD), and nuclear magnetic resonance (NMR).
|3||II||CHM 500, MATH 221, and PHYS 114|
Research Training in Biochemistry
Provides laboratory experience for majors and nonmajors in research techniques contributing to ongoing biochemical research. May be repeated up to 8 hours.
|1 to 3||I, II and S||Background adequate for relevent techniques|
An introduction to physical methods, kinetics, and thermodynamics of biochemical reactions and bioenergetics, chemistry of proteins and amino acids, carbohydrate chemistry, and metabolism. BIOCH 755 and 765 are for students interested in a two-semester comprehensive coverage of biochemistry. For a one-semester course, enroll in BIOCH 521.
|3||I||Chemical Analysis, one year of organic chemistry, differential and integral calculus|
Biochemistry I Laboratory
An intensive laboratory course to accompany BIOCH 755. BIOCH 756 and 766 are sequential courses for students interested in a two-semester comprehensive coverage of biochemistry. For a one-semester laboratory course, enroll in BIOCH 522. Six hours lab a week.
|2||I||BIOCH 755 or concurrent enrollment|
Basic methods and strategies of nuclear magnetic resonance used in the study of biological molecules. Principles and applications of simple one-dimensional and two-dimensional NMR experiements. Two three-hour laboratories per week. Meets second half of the semester.
Protein Structure Laboratory
Principles and uses of computational and experimental approaches for studying peptide and protein structure and dynamics: computer modeling and simulation techniques, fluorescence and circular dichroism spectroscopes, microcalorimetry, and analytical ultracentrifugation. Two three-hour laboratories per week. Meets first half of semester.
Continuation of BIOCH 755; lipid chemistry and metabolism, amino acid metabolism, nutrition, nucleic acid chemistry and metabolism, integration of biochemical pathways and metabolic control mechanisms.
Recombinant DNA Laboratory I
Biochemical manipulation of nucleic acids. Isolation and restriction enzyme characterization of plasmid DNA, ligation of DNA fragments to vector DNA, polymerase chain reaction, Souther blot analysis, DNA sequencing and analysis. Two three-hour labs per week. Meets first half of semester.
Recombinant DNA Laboratory II
Approaches to study of RNA and proteins using recombinant DNA techniques. RNA extraction and affinity isolation of mRNA, Northern blot analysis, cDNA library construction and screening, bacterial or eukaryotic expression systems, purification and characterization of recombinant proteins, site-directed mutagenesis. Two three-hour labs per week. Meets second half of semester.
Survey if the biophysical methods most frequently encountered in biochemistry and related disciplines. It summarized concepts and techniques of physical science used in studying the structure and function of biomacromocules such as proteins and DNA. Applications include classical equilibrium thermodynamics and analytical methods like mass spectrometry and circular dichroism (CD), fluorescence, EPR and nuclear magnetic resonance (NMR) spectroscopy. The class emphasizes the underlying principles and techniques used in determining the molecular weight and shape of biopolymers, biochemical mechanisms of action, and observation of conformational changes in macromolecules.
|3||II||CHM 350/351, MATH 221, PHYS 114, BIOCH 755,756,765|
A survey of biophysical methods most frequently encountered in biochemistry and related disciplines. Emphasizes principles underlying methods used in determining the molecular weight and shape of biopolymers and techniques used in detecting conformational changes in nucleic acids, proteins, and polysaccharides.
|3||I||MATH 221, CHM 500 and BIOCH 765|
Problems in Biochemistry
Problems may include laboratory and/or library work in various phases of biochemistry, agricultural chemistry, or nutrition.
|Varies||I, II and S||Background adequate for problems undertaken|
Seminar for graduate students in biochemistry.
|0 to 1|
Nuclear Magnetic Resonance (NMR) Spectroscopy of Macromolecules
A lecture and laboratory course on 'state-of-the-art' multi-dimensional nuclear magnetic resonance methods and strategies in solving three dimensional structure of peptides, proteins, nucleic acids and other macromolecules.
Advanced Topics in Biochemistry
Course to present timely topics in Biochemistry.
|1 to 3||Consent of instructor|
Research in Biochemistry I
Research in biochemistry which may be used for preparation of the M.S. thesis.
|Varies||Sufficient training for research undertaken|
Advanced Topics in Insect Biochemistry
In even years. Lectures, readings, and discussion of topics of current interest in insect biochemistry. Topics will include biochemical molecules and processes specific to insects, such as biochemistry of the exoskeleton and regulation of metamorphosis, as well as comparison of insect and mammalian biochemistry.
In odd years. Chemistry of plant and animal lipids, their occurrence, metabolism, and industrial uses.
Lectures on the basic principles and skills involved in computer modeling of biomolecules. Students will carry out projects that focus on practical aspects of utilizing publically available simulations and analysis tools to address questions in biochemical and biophysical research.
In even years. Structure and function of nucleic acids: structures and properties of DNA, RNA, and chromatin; recombinant DNA techniques; mutagenesis and carcinogenesis; protein-nucleic acid interactions; structural influences on replication, transcription, translation, and regulation.
In odd years. Lectures and readings on the chemical nature of proteins; fractionation; purification, structure, chemical and physical properties of proteins and amino acids.
|2||BIOCH 755 and 765|
Biochemistry of Cell Regulation
Integration of biochemical pathways and molecular mechanisms regulating cell growth, movement, differentiation, and death. Emphasis on molecular interactions and signaling cascades controlling gene expression, protein synthesis and folding, proteolysis, cytoskeletion, cell cycle, cell survival, and apoptosis.
Advanced Topics in Protein Science
In even years. Recent advances in protein biochemistry, including protein structure determination, dynamics, folding, stability, enzyme mechanism and regulation.
Postdoctoral Research in Biochemistry
Advanced level research in collaboration with a faculty member, involving projects in any area of biochemistry. Post-graduate training in first three years beyond doctorate.
|1 to 12||Ph.D. or equivalent|
Research in Biochemistry II
Research in biochemistry which may be used for preparation of the Ph.D. thesis.
|Varies||Sufficient training for research undertaken|