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Division of Biology

Division of Biology
Kansas State University
116 Ackert Hall
Manhattan, KS 66506
785-532-6615
785-532-6653 fax
biology@k-state.edu

Kristin Michel, Associate Professor

michel

Contact information

267 Chalmers Hall
(785) 532-0161
kmichel@ksu.edu

Lab website: http://www.k-state.edu/michellab

Education

Ph.D. 2002, University of California-Riverside. Entomology.

Area(s) of Specialization

Host-pathogen interactions; Vector biology.

Research Focus

My laboratory studies the innate immune system of mosquitoes and how it relates to the pathogens these insects transmit. Over the last years, we have identified a variety of immune factors that either positively or negatively affect the survival of the malaria parasite in its mosquito vector. Specifically, we are currently focusing our research effort on a group of serine protease inhibitors called serpins. These proteins control key innate immune reactions against different stages of the malaria parasite and potentially other disease agents. Our long term goal is to apply our findings to the design of novel disease control strategies, which envision the interruption of disease transmission within the mosquito vector.

Recent Primary Research Articles

Mills MK, Nayduch D, McVey DS, Michel K. 2017. Functional Validation of Apoptosis Genes IAP1 and DRONC in Midgut Tissue of the Biting Midge Culicoides sonorensis (Diptera: Ceratopogonidae) by RNAi. Journal of Medical Entomology 54(3):559-567. PubMed PMID: 28399198, PMCID: PMC5502902

Zhang X, An C, Sprigg K, Michel K. 2016. CLIPB8 is part of the prophenoloxidase activation system in Anopheles gambiae mosquitoes. Insect Biochemistry and Molecular Biology 71:106-15. PubMed PMID: 26926112, PMCID: PMC4828722

Bryant WB, Michel K. 2016. Anopheles gambiae hemocytes exhibit transient states of activation. Developmental and Comparative Immunology 55:119-29. PubMed PMID: 26515540, PMCID: PMC4685016

Zhang X, Meekins DA, An C, Zolkiewski M, Battaile KP, Kanost MR, Lovell S, Michel K. 2015. Structural and inhibitory effects of hinge loop mutagenesis in serpin-2 from the malaria vector Anopheles gambiae. The Journal of Biological Chemistry 290(5):2946-56. PubMed PMID: 25525260, PMCID: PMC4317006

Jiang X, Peery A, Hall AB, Sharma A, Chen XG, Waterhouse RM, Komissarov A, Riehle MM, Shouche Y, Sharakhova MV, Lawson D, Pakpour N, Arensburger P, Davidson VL, Eiglmeier K, Emrich S, George P, Kennedy RC, Mane SP, Maslen G, Oringanje C, Qi Y, Settlage R, Tojo M, Tubio JM, Unger MF, Wang B, Vernick KD, Ribeiro JM, James AA, Michel K, Riehle MA, Luckhart S, Sharakhov IV, Tu Z. 2014. Genome analysis of a major urban malaria vector mosquito, Anopheles stephensi. Genome Biology 15(9):459. PubMed [journal] PMID: 25244985, PMCID: PMC4195908

Bryant WB, Michel K. 2014. Blood feeding induces hemocyte proliferation and activation in the African malaria mosquito, Anopheles gambiae Giles. The Journal of Experimental Biology 217(Pt 8):1238-45. PubMed PMID: 24363411, PMCID: PMC3990356

Review Articles

Rhodes VLM and Michel K. 2017. Chapter 4: Modulation of mosquito immune defenses as a control strategy. In: “Arthropod Vector: Controller of Disease Transmission, Volume 1Vector Microbiome and Innate Immunity of Arthropods; Editors: Stephen Wikel Serap Aksoy George Dimopoulos; Academic Press, Cambridge, MA, USA; ISBN: 9780128053508. Published Date: 27th April 2017

Meekins DA, Kanost MR, Michel K. 2017. Serpins in arthropod biology. Seminars in cell & developmental biology 62:105-119. PubMed PMID: 27603121, PMCID: PMC5318264

Scott JG, Michel K, Bartholomay LC, Siegfried BD, Hunter WB, Smagghe G, Zhu KY, Douglas AE. 2013. Towards the elements of successful insect RNAi. Journal of Insect Physiology 59(12):1212-21. PubMed PMID: 24041495, PMCID: PMC3870143

View the complete publication list in NCBI