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Division of Biology

Division of Biology
Kansas State University
116 Ackert Hall
Manhattan, KS 66506
785-532-6615
785-532-6653 fax
biology@k-state.edu

Stella Y. Lee, Assistant Professor

lee

Contact information

308 Ackert Hall
(785) 532-3446
sylee@ksu.edu

Lab website: http://www.k-state.edu/leelab

Education

Ph.D. 2000, Dalhousie University, Canada. Biology.

Area(s) of Specialization

Intracellular protein transport in health and diseases; Lysosomal storage disorders; Neuronal ceroid lipofuscinosis

Research Focus

We are interested in intracellular protein transport in general.  We have recently identified a negative regulator that modulates the COPI-mediated retrograde transportfrom Golgi to ER.  Besides the fundamental research, we are also interested in understanding the mechanisms behind transport defects in diseases.  Currently we are focusing on one particular type of lysosomal storage disorders, Neuronal-Ceroid Lipofuscinosis.

Selected Publications

De Silva, B., Adams, J., and S.Y. Lee. 2015. Proteolytic processing of the neuronal ceroid lipofuscinosis related lysosomal protein CLN5.  Exp. Cell Res. doi: 10.1016/j.yexcr.2015.08.021. [Epub ahead of print]

Moharir, A., Peck, S.H., Budden, T., and S.Y. Lee. 2013. The Role of N-Glycosylation in Folding, Trafficking, and Functionality of Lysosomal Protein CLN5. PLoS ONE 8(9): e74299. doi:10.1371/journal.pone.0074299.

Hsu, V. W., S.Y. Lee, and J.S.Yang. 2009. The evolving understanding of COPI vesicle formation. Nat. Rev. Mol. Cell Biol. 10, 360-364.

Zhang, L.*, S.Y. Lee*, G.V. Beznoussenko, P.J. Peters, J.S. Yang, H.Y. Gilbert, A.L. Brass, S.J. Elledge, S.N. Isaacs, B. Moss, A. Mironov, and V.W. Hsu. 2009. A role for the host coatomer and KDEL receptor in early vaccinia biogenesis. Proc. Natl. Acad. Sci. USA 106: 163-168. (*equal contributions)

Yang, J. S., H. Gad, S.Y. Lee, A. Mironov, L. Zhang, G.V. Beznoussenko, C. Valente, G. Turacchio, A.N. Bonsra, G. Du, G. Baldanzi, A. Graziani, S. Bourgoin, M.A. Frohman, A. Luini, and V.W. Hsu. 2008. A role for phosphatidic acid in COPI vesicle fission yields insights into Golgi maintenance. Nat. Cell Biol. 10: 1146-1153.

Hsu, V.W., J.S. Yang, and S.Y. Lee. 2008. COPI: mechanisms and transport roles.  In Mironov, A. A., Pavelka, M. (Eds) The Golgi Apparatus, State of the art 110 years after Camillo Golgi’s discovery (pp87-105). Springer Wien New York.

Lee, S.Y., J.S. Yang, W. Hong, R.T. Premont, and V.W. Hsu. 2005. ARFGAP1 plays a central role in coupling COPI cargo sorting with vesicle formation. J. Cell Biol. 168: 281-290.

View the complete publication list in NCBI