Govindsamy Vediyappan

Assistant Professor

Pathogenic Microbiology, Bacterial Genetics, & Mycology

307 Ackert Hall
(785) 532-1529
gvediyap@ksu.edu

Molecular Cellular Developmental Biology Web

Research Focus

Infectious microbes have developed various mechanisms to resist antimicrobial agents. Specifically we are interested in understanding the molecular mechanisms of antimicrobial resistance through multidrug efflux pumps and biofilms formation in pathogenic bacteria and fungi. We screened for small molecules that can inhibit the efflux activity and/or biofilms formation in pathogens and have identified many promising candidates. Studying their mechanisms of action will help us to advance our knowledge in microbial resistance and to identify novel pathways/drug targets for antimicrobial development.

Selected Research Publications

Vediyappan G, T. Rossignol, and C. d'Enfert. 2010. Interaction of Candida albicans biofilms with antifungals: transcriptional response and binding of antifungals to beta-glucans. Antimicrob Agents Chemother. 54(5):2096-111.

Govind, R., G. Vediyappan, R.D. Rolfe, B. Dupuy, and J.A. Fralick. 2009. Bacteriophage mediated toxin gene regulation in Clostridium difficile. J. Virology 83 (23):12037-45.

Enjalbert, B., A. Rachini, G. Vediyappan, D. Pietrella, R. Spaccapelo, A. Vecchiarelli, A.J. Brown, and C. d'Enfert. 2009. A multifunctional, synthetic Gaussia princeps luciferase reporter for live imaging of Candida albicans infections. Infect Immun. 77(11):4847-58.

Vediyappan, G., T. Borisova, and J.A. Fralick. 2006. Isolation and characterization of VceC gain-of-function mutants that can function with the AcrAB multiple-drug-resistant efflux pump of Escherichia coli. J Bacteriol. 188(11):3757-62.

Govind, R., G. Vediyappan, R.D. Rolfe, and J.A. Fralick. 2006. Evidence that Clostridium difficile TcdC is a membrane-associated protein. J Bacteriol. 188(10):3716-20.

Vediyappan, G. and W.L. Chaffin. 2006. Non-glucan attached proteins of Candida albicans biofilm formed on various surfaces. Mycopathologia 161(1):3-10.

Woolley, R.C., G. Vediyappan,M. Anderson, M. Lackey, B. Ramasubramanian, B. Jiangping, T. Borisova, J.A. Colmer, A.N. Hamood, C.S. McVay, and J.A. Fralick. 2005. Characterization of the Vibrio cholerae vceCAB multiple-drug resistance efflux operon in Escherichia coli. J Bacteriol. 187(15):5500-3.

Rocha, E.P., J. Fralick, G. Vediyappan, A. Danchin, and V. Norris. 2003. A strand-specific model for chromosome segregation in bacteria. Mol Microbiol. 49(4):895-903.