http://www.ksu.edu/biology K-State Division of Biology
J.P.Perchellet

 

Jean-Pierre H. Perchellet

Professor

Ph.D. 1974, University of Paris VI
Endocrinology

 

28D Ackert Hall
(785) 532-7727
jpperch@ksu.edu


Research Focus

Characterization of the molecular mechanism of action of novel synthetic classes of anticancer drugs

Recent Research Publications

Perchellet JP, Perchellet EM, Singh CR, Monnett MT, Studer ER, Thornton PD, Brown N, Hill D, Neuenswander B, Lushington GH, Santini C, Buszek KR. 2014. Mechanisms by which  synthetic 6,7-annulated-4-substituted indole compounds with anti-proliferative activity disrupt mitosis and block cytokinesis in human HL-60 tumor cells in vitro. Anticancer Res 34: 1643-1656.

Perchellet J.P., A.M. Waters, E.M. Perchelle, P.D. Thornton, N. Brown, D. Hill, B. Neuenswander, G.H. Lushington, C. Santini, N. Chandrasoma, and K.R. Buszek. 2012. Antitumor effects of synthetic 6,7-annulated-4-substituted indole compounds in L1210 leukemic cells in vitro. Anticancer Res 32: 4671-4684.

Perchellet, J.P., A.M. Waters, E.M. Perchellet, V.K. Naganaboina, K.L. Chandra, J. Desper, and S. Rayat. 2011. Bioactivity of synthetic 2-halo-3-aryl-4(3H)-quinazoliniminium halides in L1210 leukemic and SK-BR-3 mammary tumor cells in vitro. Anticancer Res 31: 2083-2094.

Gundugola, A.S., K.L. Chandra, E.M. Perchellet, A.M. Waters, J.P. Perchellet, and S. Rayat. 2010. Synthesis and antiproliferative evaluation of 5-oxo and 5-thio derivatives of 1,4-diaryl tetrazoles. Bioorg Med Chem Lett: 20: 3920-3924.

Perchellet, E.M., K.R. Crow, G. Gakhar, T.A. Nguyen, A. Shi, D.H. Hua, and J.P. Perchellet. 2010. Bioactivity and molecular targets of novel substituted quinolines in murine and human tumor cell lines in vitro. Int J Oncology 36: 673-688.

Perchellet, J.P., E.M. Perchellet, K.R. Crow, K.R. Buszek, N. Brown, S. Ellappan, G. Gao, D. Luo, M. Minatoya, and G.H. Lushington. 2009. Novel synthetic inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity that inhibit tumor cell proliferation and are structurally unrelated to existing statins. Int J Mol Med 24: 633-643.

Perchellet, E.M., J.P. Perchellet, C.K. Ganta, D.L. Troyer, A. Shi, and D.H. Hua. 2009. Synthesis, molecular targets, and anti-tumor activities of substituted tetrahydro-1-oxopyrano[4,3-b][1]benzopyrans and nanogels for drug delivery. Anti-Cancer Agents in Medicinal Chemistry 9: 864-876.

Brown, N., G. Gao, M. Minatoya, B. Xie, D. VanderVelde, G.H. Lushington, J.P. Perchellet, E.M. Perchellet, K.R. Crow, and K.R. Buszek. 2008. Design and synthesis of medium-ring lactam libraries inspired by octalactin A. A convergent-divergent approach. J Comb Chem 10: 628-631.

Brown, N., B. Xie, N. Markina, D. VenderVelde, J.P. Perchellet, E.M. Perchellet, K.R. Crow, and K.R. Buszek. 2008. Synthesis of a natural product-inspired eight-membered ring lactam library via ring-closing metathesis. Bioorg Med Chem Lett 18: 4876-4679.

Hua, D.H., H. Zhao, S.K. Battina, K. Lou, A.L. Jimenez, J. Desper, E.M. Perchellet, J.P. Perchellet, and P.K. Chiang. 2008. Total syntheses of (±)-ovalicin, C4(S*)-isomer, and its C5-analogs and anti-trypanosomal activities. Bioorg Med Chem 16: 5232-5246.

Perchellet, E.M., Y. Wang,K.  Lou, H. Zhao, S.K. Battina, D.H. Hua, and J.P. Perchellet.  2007.   Antitumor triptycene analogs directly interact with isolated mitochondria to rapidly trigger markers of permeability transition.  Anticancer Res 27: 3259-3272.

Perchellet, E.M., Y. Wang, K. Lou, H. Zhao, S.K. Battina, D.H. Hua, and J.P. Perchellet. 2007.  Novel substituted 1,4 anthracenediones with antitumor activity directly induce permeability transition in isolated mitochondria. Int J Oncology 31: 1231-1241.

Hua, D.H., K. Lou, S.K. Battina, H. Zhao, E.M. Perchellet, Y. Wang, and J.P. Perchellet.  2006.  Syntheses, molecular targets and antitumor activities of novel triptycene bisquinones and 1,4-anthracenedione analogs. Anti-Cancer Agents in Medicinal Chemistry 6: 303-318.

Perchellet, E.M., M.M. Ward, A.-L. Skaltsounis, I.K. Kostakis, N. Pouli, P. Marakos, and J.P. Perchellet.  2006.   Antiproliferative and proapoptotic activities of pyranoxanthenones, pyranothioxanthenones, and their pyrazole-fused derivatives in HL-60 cells. Anticancer Res 26: 2791-2804.

Wang,Y., E.M. Perchellet, M.M. Ward, K. Lou, H. Zhao, S.K. Battina, B. Wiredu,D.H.  Hua, and J.P. Perchellet.  2006.  Antitumor triptycene analogs induce a rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria. Int J Oncology 28: 161-172.

Perchellet, E.M., J.P. Perchellet, and P.W. Baures.  2005.  Imidazole-4,5-dicarboxamide derivatives with antiproliferative activity against HL-60 cells. J Med Chem 48: 5955-5965.

Wang Y, E.M. Perchellet, M.M. Ward, K. Lou, D.H. Hua, and J.P. Perchellet.  2005.  Rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria treated with antitumor 1,4-anthracenediones. Anti-Cancer Drugs 16: 953-967.

Perchellet, E.M., Y. Wang, R.L. Webe, K. Lou, D.H. Hua,and J.P. Perchellet.  2004.  Antitumor triptycene bisquinones induce a caspase-independent release of mitochondrial cytochrome c and a caspase-2-mediated activation of initiator caspase-8 and -9 in HL-60 cells by a mechanism which does not involve Fas signaling.  Anti-Cancer Drugs 15: 929-946.

Perchellet, E.M., Y. Wang, R.L. Weber, B.J. Sperfslage, K. Lou, J. Crossland, D.H. Hua, and J.P. Perchellet.  2004.  Synthetic 1,4-anthracenedione analogs induce cytochrome c release, caspase-9, -3, and -8 activities, poly(ADP-ribose) polymerase-1 cleavage and internucleosomal DNA fragmentation in HL-60 cells by a mechanism which involves caspase-2 activation but not Fas signaling.  Biochem  Pharmacol 67: 523-537.

Wang, B., E.M. Perchellet, Y. Wang, M. Tamura, D.H. Hua, and J.P. Perchellet.  2003.  Antitumor triptycene bisquinones: a novel synthetic class of dual inhibitors of DNA topoisomerase I and II activities.  Anti-Cancer Drugs 14: 503-514.

Perchellet, E.M., B.J. Sperfslage, Y. Wang, X. Huang, M. Tamura, D.H. Hua, and J.P. Perchellet.  2002.  Among substituted 9,10- dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetraones, the lead antitumor triptycene bisquinone TT24 blocks nucleoside transport, induces apoptotic DNA fragmentation and decreases the viability of L1210 leukemic cells in the nanomolar range of daunorubicin in vitro.  Anti-Cancer Drugs 13: 567-582.

Wang, Y., E.M. Perchellet, M. Tamura, D.H. Hua, and J.P. Perchellet.  2002. Induction of poly(ADP-ribose) polymerase-1 cleavage by antitumor triptycene bisquinones in wild-type and daunorubicin-resistant HL-60 cell lines. Cancer Letters 188: 73-83.

 

Complete List of Research Publications -(PDF)


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