Perchellet J.P., A.M. Waters, E.M. Perchelle, P.D. Thornton, N. Brown, D. Hill, B. Neuenswander, G.H. Lushington, C. Santini, N. Chandrasoma, and K.R. Buszek. 2012. Antitumor effects of synthetic 6,7-annulated-4-substituted indole compounds in L1210 leukemic cells in vitro. Anticancer Res 32: 4671-4684.
Perchellet, J.P., A.M. Waters, E.M. Perchellet, V.K. Naganaboina, K.L. Chandra, J. Desper, and S. Rayat. 2011. Bioactivity
of synthetic 2-halo-3-aryl-4(3H)-quinazoliniminium halides in L1210 leukemic and SK-BR-3
mammary tumor cells in vitro. Anticancer Res 31: 2083-2094.
Gundugola, A.S., K.L. Chandra, E.M. Perchellet, A.M. Waters, J.P. Perchellet, and S. Rayat. 2010. Synthesis and
antiproliferative evaluation of 5-oxo and 5-thio derivatives of 1,4-diaryl tetrazoles. Bioorg Med Chem
Lett: 20: 3920-3924.
Perchellet, E.M., K.R. Crow, G. Gakhar, T.A. Nguyen, A. Shi, D.H. Hua, and J.P. Perchellet. 2010. Bioactivity and molecular
targets of novel substituted quinolines in murine and human tumor cell lines in vitro. Int J Oncology 36: 673-688.
Perchellet, J.P., E.M. Perchellet, K.R. Crow, K.R. Buszek, N. Brown, S. Ellappan, G. Gao, D. Luo, M. Minatoya,
and G.H. Lushington. 2009. Novel synthetic inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA)
reductase activity that inhibit tumor cell proliferation and are structurally unrelated to existing statins. Int J Mol Med 24: 633-643.
Perchellet, E.M., J.P. Perchellet, C.K. Ganta, D.L. Troyer, A. Shi, and D.H. Hua. 2009. Synthesis, molecular targets, and
anti-tumor activities of substituted tetrahydro-1-oxopyrano[4,3-b][1]benzopyrans and nanogels for
drug delivery. Anti-Cancer Agents in Medicinal Chemistry 9: 864-876.
Brown, N., G. Gao, M. Minatoya, B. Xie, D. VanderVelde, G.H. Lushington, J.P. Perchellet, E.M. Perchellet,
K.R. Crow, and K.R. Buszek. 2008. Design and synthesis of medium-ring lactam libraries inspired by octalactin
A. A convergent-divergent approach. J Comb Chem 10: 628-631.
Brown, N., B. Xie, N. Markina, D. VenderVelde, J.P. Perchellet, E.M. Perchellet, K.R. Crow, and K.R. Buszek. 2008.
Synthesis of a natural product-inspired eight-membered ring lactam library via ring-closing
metathesis. Bioorg Med Chem Lett 18: 4876-4679.
Hua, D.H., H. Zhao, S.K. Battina, K. Lou, A.L. Jimenez, J. Desper, E.M. Perchellet, J.P. Perchellet, and P.K. Chiang. 2008. Total syntheses of (±)-ovalicin, C4(S*)-isomer, and its C5-analogs and anti-trypanosomal activities. Bioorg Med Chem 16: 5232-5246.
Perchellet, E.M., Y. Wang,K. Lou, H. Zhao, S.K. Battina, D.H. Hua, and J.P. Perchellet. 2007. Antitumor triptycene analogs directly interact with isolated mitochondria to rapidly trigger markers of permeability transition. Anticancer Res 27: 3259-3272.
Perchellet, E.M., Y. Wang, K. Lou, H. Zhao, S.K. Battina, D.H. Hua, and J.P. Perchellet. 2007. Novel substituted 1,4 anthracenediones with antitumor activity directly induce permeability transition in isolated mitochondria. Int J Oncology 31: 1231-1241.
Hua, D.H., K. Lou, S.K. Battina, H. Zhao, E.M. Perchellet, Y. Wang, and J.P.
Perchellet. 2006. Syntheses, molecular targets and antitumor activities of novel triptycene
bisquinones and 1,4-anthracenedione analogs. Anti-Cancer Agents in
Medicinal Chemistry 6: 303-318.
Perchellet, E.M., M.M. Ward, A.-L. Skaltsounis, I.K. Kostakis, N. Pouli, P.
Marakos, and J.P. Perchellet. 2006. Antiproliferative and proapoptotic activities of pyranoxanthenones,
pyranothioxanthenones, and their pyrazole-fused derivatives in HL-60 cells. Anticancer Res 26: 2791-2804.
Wang,Y., E.M. Perchellet, M.M. Ward, K. Lou, H. Zhao, S.K. Battina, B.
Wiredu,D.H. Hua, and J.P. Perchellet. 2006. Antitumor triptycene analogs induce a rapid collapse of mitochondrial
transmembrane potential in HL-60 cells and isolated mitochondria. Int J
Oncology 28: 161-172.
Perchellet,
E.M., J.P. Perchellet, and P.W. Baures. 2005. Imidazole-4,5-dicarboxamide
derivatives with antiproliferative activity against HL-60 cells. J Med
Chem 48: 5955-5965.
Wang Y, E.M. Perchellet, M.M. Ward, K. Lou, D.H. Hua, and J.P. Perchellet.
2005. Rapid
collapse of mitochondrial transmembrane potential in HL-60 cells and isolated
mitochondria treated with antitumor 1,4-anthracenediones. Anti-Cancer
Drugs 16: 953-967.
Perchellet,
E.M., Y. Wang, R.L. Webe, K. Lou, D.H. Hua,and J.P. Perchellet. 2004. Antitumor
triptycene bisquinones induce a
caspase-independent release of mitochondrial cytochrome c and a caspase-2-mediated activation of
initiator caspase-8 and -9 in HL-60 cells by a mechanism which does not involve
Fas signaling. Anti-Cancer Drugs 15: 929-946.
Perchellet,
E.M., Y. Wang, R.L. Weber, B.J. Sperfslage, K. Lou, J. Crossland, D.H. Hua, and
J.P. Perchellet. 2004. Synthetic
1,4-anthracenedione analogs induce cytochrome c release, caspase-9, -3,
and -8 activities, poly(ADP-ribose) polymerase-1 cleavage and internucleosomal
DNA fragmentation in HL-60 cells by a mechanism which involves caspase-2
activation but not Fas signaling. Biochem
Pharmacol 67: 523-537.
Wang,
B., E.M. Perchellet, Y. Wang, M. Tamura, D.H. Hua, and J.P. Perchellet. 2003. Antitumor
triptycene bisquinones: a novel synthetic
class of dual inhibitors of DNA topoisomerase I and II activities. Anti-Cancer Drugs 14: 503-514.
Perchellet, E.M., B.J. Sperfslage, Y. Wang, X.
Huang, M. Tamura, D.H. Hua, and J.P. Perchellet.
2002. Among
substituted 9,10- dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetraones,
the lead antitumor triptycene bisquinone TT24 blocks
nucleoside transport, induces apoptotic DNA fragmentation and decreases the
viability of L1210 leukemic cells in the
nanomolar range of daunorubicin in vitro. Anti-Cancer Drugs 13: 567-582.
Wang, Y., E.M. Perchellet, M. Tamura, D.H. Hua,
and J.P. Perchellet. 2002. Induction of poly(ADP-ribose) polymerase-1 cleavage by antitumor triptycene bisquinones in wild-type and daunorubicin-resistant HL-60 cell lines. Cancer Letters 188: 73-83.
